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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Plasma and urine heine oxy- genase-1 in acute kidney injury显示文摘 | Zager R A Johnson A C Becker K | 2012 | J AM Soc Nephrol2012，23，6： | 1 |
| 3 | 'U' curve association of blood pressure and mortality in hemodialysis patients 显示文摘 | Zager P Nikolic J Brown R | 1998 | Kidney Int1998，54，： | 1 |
| 4 | Developmental well-being in offspring of women receiving cyclosporine post-renal transplant显示文摘 | Stanley CW Gottileb R Zager R | 1999 | Transplant Proc1999，31，12： | 1 |
| 5 | Plasma andurinary heme oxygenase-1 in AKI 显示文摘 | ZAGER R A JOHNSON AC BECKER K | 2012 | J Am Soc Nephrol2012，23，6： | 1 |
| 6 | Developmental wellbeing in offspring of women receiving cyclosporine post-renal transplant显示文摘 | Stanley CW Gottlieb R Zager R | 1999 | Transplant Proc1999，31，： | 1 |
| 7 | Multidrug- resistant tuberculosis 显示文摘 | Zager EM McNerney R | 2008 | BMC Infect Dis2008，8，： | 1 |
| 8 | Hypocalcemia:a per vasive metabolic abnormality in the critically ill显示文摘 | ZIVIN J R GOOLEY T ZAGER R A | 2001 | Am J Kidney Dis2001，37，4： | 1 |
| 9 | Renal tubular triglyercide accumulation following endotoxic, toxic, and isehemic injury 显示文摘 | Zager R A Johnson A C Hanson S Y | 2005 | Kidney Int2005，67，11： | 1 |
| 10 | Hypocalcemia: A pervasive metabolic abnormality in the critically ill显示文摘 | Zivin J R Gooley T Zager R A | 2001 | Am J Kidney Dis2001，37，4： | 1 |
| 11 | Assessment of low- flow sevoflurane and isoflurane effects on renal function using sen- sitive markers of tubular toxicity 显示文摘 | Kharasch ED Frink EJ Jr Zager R | 1997 | Anesthesiology1997，86，6： | 1 |
| 12 | Uremia impacts renalinflammatory cytokine gene expression in the setting ofexperimental acute kidney injury显示文摘 | Zager R A Johnson A C Lund S | 2009 | Am J Physiol Re-nal Physiol2009，297，： | 1 |
| 13 | 'U'-curve association of blood pressure and mortality in hemodialysis patients 显示文摘 | Zager P H Nikolic J Brown R H | 1998 | Kidney Int1998，54，2： | 1 |
| 14 | Multidrug-resistant tuberculosis 显示文摘 | Zager EM Nerney R | 2008 | BMC Infect Dis2008，8，： | 1 |
| 15 | Current diagnosis andmanagement of retroperitoneal sarcoma显示文摘 | Mullinax J E Zager J S Gonzalez R J | 2011 | Cancer control2011，18，3： | 1 |
| 16 | Comparison of oxidative stress markers after intra venous administration of iron dextran, sodium ferric gluconate, and iron sucrose in patients undergoing hemodialysis显示文摘 | Pai A B Boyd A V McQuade C R Harford A Norenberg J P Zager P G | 2007 | Phar macot herapy2007，27，： | 1 |
| 17 | Pathogenetic mechanisms in experimental hemoglobinuric acute renal failure显示文摘 | GAMELIN L M | 1989 | Am J Physioj1989，256，： | 1 |
| 18 | Renal tubular triglyercide accumulation following endotoxic, toxic, and ischemic injury 显示文摘 | Zager R A Johnson A C Hanson S Y | 2005 | Kidney Int2005，67，1： | 1 |
| 19 | Radiographic contrast media-induced tubular injury: evaluation of oxidant stress and plasma membrane integrity显示文摘 | ZAGER R A JOHNSON A C HANSON S Y | 2003 | Kidney Int2003，64，： | 1 |
| 20 | Developmental wellbeing in offspring of wbmen receiving cyclosporine post-renal transplant显示文摘 | Stanley C W Gottlieb R Zager R | 1999 | Transplant Proc1999，31，： | 1 |
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