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| 1 | Cholangiocarcinoma:principles and current trends显示文摘BACKGROUND:Cholangiocarcinoma(CCA)is a lethal cancer of the biliary epithelium,originating from the liver(intrahepatic),at the confluence of the right and left hepatic ducts(hilar)or in the extrahepatic bile ducts.It is a rare malignancy associated with poor prognosis.DATA SOURCES:We searched the PubMed/MEDLINE database for relevant articles published from 1989 to 2008.The search terms used were related to 'cholangiocarcinoma' and its ' treatment'.Although no language restrictions were imposed initially,for the full-text review and final analysis,our resources only permitted the review of articles published in English.This review deals with the treatment of cholangiocarcinoma,the principles and the current trends.RESULTS:The risks and prognostic factors,symptoms and differential diagnosis are thoroughly discussed.In addition,the tools of preoperative diagnosis such as endoscopic retrograde cholangiopancreatography,digital image analysis,fluorescence in situ hybridization and magnetic resonance cholangiopancreatography are reviewed.Moreover,the treatment of CCA is discussed.CONCLUSIONS:The only curative treatment available is surgical management.Unfortunately,many patients present with unresectable tumors,the majority of whom die within a year of diagnosis.Surgical treatment involves major resections of the liver,pancreas and bile duct,with considerable mortality and morbidity.However,in selected cases and where indicated,appropriate management with aggressive surgery may achieve a good outcome with a prolonged survival expectancy. | George N Zografos Athanasios Farfaras Flora Zagouri Dimosthenis Chrysikos Kostas Karaliotas | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，1： | 14 |
| 2 | Gastrointestinal stromal tumor causing small bowel intussusception in a patient with Crohn’s disease显示文摘We report a case of jejunoileal intussusception in a 42-year-old patient with Crohn's disease caused by a gastrointestinal stromal tumor. The patient complained of vague diffuse abdominal pain for a period of 4 mo. Intussusception was suspected at computer tomography and magnetic resonance imaging scans. Segmental resection of the small intestine was performed. Pathological examination of the surgical specimen revealed a gastrointestinal stromal tumor as well as aphthous ulcerations and areas of inflammation, which were characteristic of Crohn's disease. This is the f irst report of small bowel intussusception due to a gastrointestinal stromal tumor coexisting with Crohn's disease. | George E Theodoropoulos Dimitrios Linardoutsos Dimitrios Tsamis Paraskevas Stamopoulos Dimitrios Giannopoulos Flora Zagouri Nikolaos V Michalopoulos | 2009 | World Journal of Gastroenterology2009，15，41： | 7 |
| 3 | Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma显示文摘 | Zagouri F Sergentanis TN Zografos GC | 2007 | World J Sur Oncol2007，5，： | 1 |
| 4 | Aromatase inhibitors with or without gonadotropin-releasing hormone analogue in metastatic male breast cancer: a case series显示文摘 | Zagouri F Sergentanis TN Koutoulidis V | 2013 | Br J Cancer2013，108，： | 1 |
| 5 | Challenges in managing breast cancer during pregnancy 显示文摘 | Zagouri F Psaltopoulou T Dimitrakakis C | 2013 | Journal of Thoracic Disease2013，5，1： | 1 |
| 6 | Precursors and preinvasive lesions of the breast: the role of molecular prog nostic markers in the diagnostic and therapeutic dilemma 显示文摘 | Zagouri F Sergentanis TN Zografos GC | 2007 | World J Surg Oncol2007，5，： | 1 |
| 7 | Aromatase inhibitors with or without gonadotropin-releasing hormone analogue in metastatic male breast cancer: a case series显示文摘 | Zagouri F Sergentanis TN Koutoulidis V | 2013 | Br J Cancer2013，108，11： | 1 |
| 8 | Aromatase inhibitors in male breast cancer: a pooled analysis 显示文摘 | Zagouri F Sergentanis TN Azim HA Jr et aI | 2015 | Breast Cancer Res Treat2015，151，1： | 1 |
| 9 | Needle tract seeding after vacuum-aasiated breast biopsy显示文摘 | Michalopoulos NV Zagouri F Sergentanis TN | | 0，，03： | 1 |
| 10 | Challenges in managing breast cancer during pregnancy显示文摘 | Zagouri F Psaltopoulou T Dim'itrakakis C | 2013 | J Thorae Dis2013，5，1： | 1 |
| 11 | Molecularly targeted therapies in unresectable-meta~tatic gastric cancer: a systematic review 显示文摘 | Zagouri F Papadimitriou CA Dimopoulos MA | 2011 | Cancer Treat Rev2011，37，8： | 1 |
| 12 | Breast ductal endoscopy: how many procedures qualify?显示文摘 | Zagouri F Sergentanis TN Giannakopoulou G | 2009 | BMC Res Notes2009，2，： | 1 |
| 13 | Pheochromocy- toma associated with neurofibromatosis type 1: concepts and current trends显示文摘 | Zogarfos GN Vasiliadis GK Zagouri F | 2010 | World J Surg Oncol2010，8，： | 1 |
| 14 | Challenges in managing breast cancer during pregnancy显示文摘 | Zagouri F Psaltopoulou T Dimitrakakis C | 2013 | J Thorac Dis2013，51，： | 1 |
| 15 | Acute intermittent porphyria in pregnancy: a common misdiagnosis 显示文摘 | Farfaras A Zagouri F Zografos G | 2010 | Clin Exp Obstet Gynecol2010，37，4： | 1 |
| 16 | High MET expression is an adverse prognostic factor in patients with triple-negative breast cancer显示文摘 | Zagouri F Bago-Horvath Z Rossler F | 2013 | Br J Cancer2013，108，5： | 1 |
| 17 | Endometrial cancer: what is new in adjuvant and molecularly targeted therapy? 显示文摘 | Zagouri F Bozas G Kafantari E | 2010 | Obstet Gynecol Int2010，2010，74： | 1 |
| 18 | Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma显示文摘 | Zagouri F Sergentanis T N Zografos G C | 2007 | World J Surg Oncol2007，5，： | 1 |
| 19 | Vacuum-assisted breast biopsy in close proximity to the skin:a case report显示文摘 | Zagouri F Sergentanis TN Koulocheri D | 2008 | J Med Case Reports2008，2，： | 1 |
| 20 | Is antibiotic use a risk fac- tor for breast cancer? A meta- analysis 显示文摘 | Sergentanis TN Zagouri F Zografos GC | 2010 | Pharrnaeoepidemiol Drug Saf2010，19，11： | 1 |
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