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| 1 | Telbivudine vs tenofovir in hepatitis B e antigen-negative chronic hepatitis B patients: OPTIMA roadmap study显示文摘AIM To make efficacy and safety comparison of telbivudineraodmap and tenofovir-roadmap in hepatitis B e antigen(HBe Ag)-negative chronic hepatitis B(CHB) patients.METHODS This was the first prospective, randomised, two-arm, open-label, non-inferiority study in HBe Ag-negative CHB patients that compared telbivudine and tenofovir administered as per roadmap concept. Patients were treated up to 24 wk and, depending on virologic response, continued the same therapy or received addon therapy up to 104 wk. Eligible patients received an additional 52 wk of treatment in the extension period(i.e., up to 156 wk). Patients who developed virologic breakthrough(VB) while on monotherapy also received add-on therapy. The primary efficacy endpoint was the rate of patients achieving hepatitis B virus(HBV) DNA < 300 copies/m L at week 52. Secondary efficacy endpoints included the rates of HBV DNA < 300 and < 169 copies/m L, HBV DNA change from baseline, alanine aminotransferase normalisation, hepatitis B surface antigen(HBs Ag) loss, HBs Ag seroconversion, VB, and emergence of resistance at various timepoints throughout the study. Safety and estimated glomerular filtration rate(e GFR) were also analysed.RESULTS A total of 241 patients were randomised. Non-inferiority of telbivudine arm to tenofovir arm was demonstrated at week 52(± 7 d window), with over 91% of patients in each treatment arm achieving HBV DNA level < 300 copies/m L. Both arms were similar in terms of key secondary efficacy variables at weeks 104 and 156. The percentage of patients achieving HBV DNA < 300 copies/m L remained high and was similar in the telbivudine and tenofovir arms at both weeks 104 and 156. Over 82% of patients in both arms achieved alanine aminotransferase normalisation at week 52, and this percentage remained high at weeks 104 and 156. Telbivudine treatment progressively reduced serum HBs Ag levels from baseline while no change was reported in quantitative HBs Ag during therapy with tenofovir. Both treaments showed acceptable safety profiles. The telbivudine arm showed e GFR improvement unlike the tenofovir arm.CONCLUSION Efficacy was shown for both telbivudine-roadmap and tenofovir-roadmap regimens in HBe Ag-negative CHB patients over 156 wk. Telbivudine arm was associated with renal improvement. | Zahari Krastev Diana Petrova Iskren Kotzev Mustafa Kemal Celen Meryl Mendelson Richa Chandra Priti Pandey Kamal Hamed | 2016 | World Journal of Hepatology2016，8，32： | 9 |
| 2 | 集成 3D 的一条通用途径当模特儿进虚拟生产显示文摘各种各样的 3D 建模软件为设计被开发了并且生产。商业地可得到的软件使用土著人文件格式的大多数,它不能被另外的软件读或理解。这份报纸为虚拟生产处理一个 3D 模型变换程序的一条通用途径的开发(VM ) ,用一条词汇分析器生成器法律和开的图形的图书馆(OpenGL ) 。程序能变换在四种通用文件格式之间的 3D 网孔数据,即, Stereolithography (STL ) ,虚拟现实建模语言(VRML ) ,可扩展的标注语言(XML ) ,和目标(OBJ ) 。简单集会功能能被用于进口模型。四元数角度被用于目标旋转克服万向节锁的问题或旋转自由的一度的损失。程序被进口中立格式模型进程序验证了,使用转变,救有一个新坐标系统的新模特儿,并且最后出口进另外的商业软件。结果证明程序能精确地显示并且重排从不同通用文件格式和那的几何学数据它能在 VM 被使用。因此,从一个 VM 系统的产量模型能在一种通用文件格式被转移或进口到另一个 VM 系统。 | Hwa-Jen YAP Zahari TAHA Siti Zawiah Md DAWAL | 2012 | Journal of Zhejiang University-Science C(Computers and Electronics)2012，13，1： | 6 |
| 3 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 5 |
| 4 | Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients显示文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes. | Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh Venkatesh R Naik | 2012 | World Journal of Gastroenterology2012，18，8： | 3 |
| 5 | Extrahepatic cholangiocarcinoma:Current status of endoscopic approach and additional therapies显示文摘The prognosis of patients with advanced or unresectable extrahepatic cholangiocarcinoma is poor.More than 50%of patients with jaundice are inoperable at the time of first diagnosis.Endoscopic treatment in patients with obstructive jaundice ensures bile duct drainage in preoperative or palliative settings.Relief of symptoms(pain,pruritus,jaundice)and improvement in quality of life are the aims of palliative therapy.Stent implantation by endoscopic retrograde cholangiopancreatography is generally preferred for long-term palliation.There is a vast variety of plastic and metal stents,covered or uncovered.The stent choice depends on the expected length of survival,quality of life,costs and physician expertise.This review will provide the framework for the endoscopic minimally invasive therapy in extrahepatic cholangiocarcinoma.Moreover,additional therapies,such as brachytherapy,photodynamic therapy,radiofrequency ablation,chemotherapy,molecular-targeted therapy and/or immunotherapy by the endoscopic approach,are the nonsurgical methods associated with survival improvement rate and/or local symptom palliation. | Alina Ioana Tantau Alina Mandrutiu Anamaria Pop Roxana Delia Zaharie Dana Crisan Carmen Monica Preda Marcel Tantau Voicu Mercea | 2021 | World Journal of Hepatology2021，13，2： | 3 |
| 6 | Antiplasmodial and Antioxidant Isoquinoline Alkaloids from Dehaasialongipedicellata显示文摘 | Azeana Zahari Foo Cheah Jamaludin Mohamad Syazreen Sulaiman Marc Litaudon Kok Leong Khalijah Awang | 2014 | Planta Med2014，，： | 2 |
| 7 | Short' z' bunionectomy 显示文摘 | Glickman S Zahari DT | 1986 | Foot Surg1986，，25： | 1 |
| 8 | Three-Year Efficacy and Safety of Tenofovir Disoproxil Fumarate Treatment for Chronic Hepatitis B显示文摘 | E. Jenny Heathcote Patrick Marcellin Maria Buti Edward Gane Robert A. De Man Zahary Krastev George Germanidis Samuel S. Lee Robert Flisiak Kelly Kaita Michael Manns Iskren Kotzev Konstantin Tchernev Peter Buggisch Frank Weilert Oya Ovunc Kurdas Mitchell L | 2011 | Gastroenterology2011，，1： | 1 |
| 9 | Influence of crossover on the behavior of Differential Evolution Algorithms显示文摘 | Daniela Zaharie | 2009 | Applied Soft Computing Journal2009，，3： | 1 |
| 10 | Newborn LpL (Ser447Stop, Asn291Ser) genotypes and the interaction with maternal genotypes influence the risk for different types of preeclampsia: modulating effect on lipid profile and pregnancy outcome 显示文摘 | PROCOPCIUC LM ZAHARIE G CARACOSTEA G | 2014 | Gynecol Endocrinol2014，30，3： | 1 |
| 11 | Complete characterisation of lanolin steryl esters by sub-ambient pressure gas chromatography-mass spectrometry in the electron impact and chemical ionisation modes显示文摘 | Zaharie Moldovan Josep Maria Bayona | 2002 | Journal of Chromatography A2002，970，： | 1 |
| 12 | A fuzzy AHP -ANN -based decision support system for machine tool selection in a flexible manufactur- ing cell 显示文摘 | Zahari Taha Sarkawt Rostam | 2011 | The International Journal of Advanced Manufacturing Technology2011，57，58： | 1 |
| 13 | Optimal multi-material selection for lightweight design of automotive body assembly incorporating recyclability显示文摘 | Novita Sakundarini Zahari Taha Salwa Hanim Abdul-Rashid Raja Ariffin Raja Ghazil | 2013 | Materials and Design2013，50，： | 1 |
| 14 | Pelvic floormuscle training improves sexual function of women withstress urinary incontinence显示文摘 | Zahariou AG Karamouti MV Papaioannou PD | 2008 | Int Urogynecol J PelvicFloor Dysfunct2008，19，3： | 1 |
| 15 | Thinned planar ar-ray design using boolean PSO with velocity mutation显示文摘 | DELIGKARIS K V ZAHARIS Z D | 2009 | IEEE Transactions on Magnetics2009，45，3： | 1 |
| 16 | The management of difficult abdominal closure after pediatric liver transplantation 显示文摘 | Ong TH Strong R Zahari Z | 1996 | J Pediatr Surg1996，31，2： | 1 |
| 17 | Pelvic floormuscle training improves sexual function of women with stress urinary incontinence 显示文摘 | Zahariou AG KaramoutiMV Papaioannou PD | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，，3： | 1 |
| 18 | On the design of a dual-band base station wire antenna显示文摘 | Zaharis Z Vafiadis E Sahalos J N | 2000 | IEEEAntennas and Propagation Magazine2000，，： | 1 |
| 19 | Is HCI duloxetine effective in the management of urinary stress incontinence after radical prestatectomy? 显示文摘 | Zahariou A Papaioannou P Kalogirou G | 2006 | Urellnt2006，77，1： | 1 |
| 20 | ProphylacticCPAP versus therapeutic CPAP in preterm newborns of28- 32 gestational weeks 显示文摘 | Zaharie G Ion DA Schmidt N | 2008 | Pneumologia2008，57，1： | 1 |
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