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| 1 | Angiogenic peptide hydrogels for treatment of traumatic brain injury显示文摘Traumatic brain injury(TBI)impacts over 3.17 million Americans.Management of hemorrhage and coagulation caused by vascular disruption after TBI is critical for the recovery of patients.Cerebrovascular pathologies play an important role in the underlying mechanisms of TBI.The objective of this study is to evaluate a novel regenerative medicine for the injured tissue after brain injury.We utilized a recently described synthetic growth factor with angiogenic potential to facilitate vascular growth in situ at the injury site.Previous work has shown how this injectable self-assembling peptide-based hydrogel(SAPH)creates a regenerative microenvironment for neovascularization at the injury site.Supramolecular assembly allows for thixotropy;the injectable drug delivery system provides sustained in vivo efficacy.In this study,a moderate blunt injury model was used to cause physical vascular damage and hemorrhage.The angiogenic SAPH was then applied directly on the injured rat brain.At day 7 post-TBI,significantly more blood vessels were observed than the sham and injury control group,as well as activation of VEGF-receptor 2,demonstrating the robust angiogenic response elicited by the angiogenic SAPH.Vascular markers von-Willebrand factor(vWF)andα-smooth muscle actin(α-SMA)showed a concomitant increase with blood vessel density in response to the angiogenic SAPH.Moreover,blood brain barrier integrity and blood coagulation were also examined as the parameters to indicate wound recovery post TBI.Neuronal rescue examination by NeuN and myelin basic protein staining showed that the angiogenic SAPH may provide and neuroprotective benefit in the long-term recovery. | Xiaotang Ma Agnieszka Agas Zain Siddiqui KaKyung Kim Patricia Iglesias-Montoro Jagathi Kalluru Vivek Kumar James Haorah | 2020 | Bioactive Materials2020，5，1： | 3 |
| 2 | Translation, validation and psycho- metric properties of Bahasa Malaysia Version of the Depression Anxiety and Stress Scales(DASS) 显示文摘 | Musa R Fadzil MA Zain Z | 2007 | Asian Journal of Psychi- atry2007，8，2： | 1 |
| 3 | Lip and oral commissure re- construction with the radial tbrearm flap 显示文摘 | Sasidaran R Zain MA Basiron NH | 2012 | Natl J MaxilLofac Surg2012，5，1： | 1 |
| 4 | Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia显示文摘 | Zain MA Roffeei SN Zainal NZ | 2013 | Psychiatr Genet2013，23，6： | 1 |
| 5 | A novel microbiota stratification system predicts future exacerbations in bronchiectasis 显示文摘 | Rogers GB Zain NM Bruce KD Burr LD Chen AC Rivett DW Mcguckin MA Serisier DJ | 2014 | Ann Am Thorac Soc2014，11，4： | 1 |
| 6 | Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration 显示文摘 | Zain MA Jahan SN Reynolds GP | 2012 | BMC Med Genet2012，13，9： | 1 |
| 7 | Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia 显示文摘 | Zain MA Roffeei SN Zainal NZ | 2013 | Psychiatr Genet2013，23，6： | 1 |
| 8 | A new efficient normal parameter reduction algorithm of soft sets显示文摘 | Ma S Sulaiman N Qin H Herawan T Zain J M | 2011 | Computers and Mathematics with Applications2011，62，2： | 1 |
| 9 | Lip and oral commissure reconstruction with the radial forearm flap显示文摘 | Sasidaran R Zain MA Basiron NH | 2012 | Natl J Maxillofac Surg2012，3，1： | 1 |
| 10 | Medical therapy vs early revascularization in diabetics with chronic total occlusions:A meta-analysis and systematic review显示文摘BACKGROUND Management of chronic total occlusions(CTO)in diabetics is challenging,with a recent trend towards early revascularization[ER:Percutaneous coronary intervention(PCI)and bypass grafting]instead of optimal medical therapy(OMT).We hypothesize that ER improves morbidity and mortality outcomes in diabetic patients with CTOs as compared to OMT.AIM To determine the long term clinical outcomes and to compare morbidity and mortality between OMT and ER in diabetic patients with CTOs.METHODS Potentially relevant published clinical trials were identified in Medline,Embase,chemical abstracts and Biosis(from start of the databases till date)and pooled hazard ratios(HR)computed using a random effects model,with significant P value<0.05.Primary outcome of interest was all-cause death.Secondary outcomes included cardiac death,prompt revascularization(ER)or repeat myocardial infarction(MI).Due to scarcity of data,both Randomized control trials and observational studies were included.4 eligible articles,containing 2248 patients were identified(1252 in OMT and 1196 in ER).Mean follow-up was 45-60 mo.RESULTS OMT was associated with a higher all-cause mortality[HR:1.70,95%confidence interval(CI):0.80-3.26,P=0.11]and cardiac mortality(HR:1.68,95%CI:0.96-2.96,P=0.07).Results were close to significance.The risk of repeat MI was almost the same in both groups(HR:0.97,95%CI:0.61-1.54,P=0.90).Similarly,patients assigned to OMT had a higher risk of repeat revascularization(HR:1.62,95%CI:1.36-1.94,P<0.00001).Sub-group analysis of OMT vs PCI demonstrated higher all-cause(HR:1.98,95%CI:1.36-2.87,P=0.0003)and cardiac mortality(HR:1.87,95%CI:0.96-3.62,P=0.06)in the OMT group.The risk of repeat MI was low in the OMT group vs PCI(HR:0.53,95%CI:0.31-0.91,P=0.02).Data on repeat revascularization revealed no difference between the two(HR:1.00,95%CI:0.52-1.93,P=1.00).CONCLUSION In diabetic patients with CTO,there was a trend for improved outcomes with ER regarding all-cause and cardiac death as compared to OMT.These findings were reinforced with statistical significance on subgroup analysis of OMT vs PCI. | Muhammad Shayan Khan Farhad Sami Hemindermeet Singh Waqas Ullah Ma'en Al-Dabbas Khalid Hamid Changal Tanveer Mir Zain Ali Ameer Kabour | 2020 | World Journal of Cardiology2020，12，11： | 0 |
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