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| 1 | Alcohol,inflammation,and gut-liver-brain interactions in tissue damage and disease development显示文摘Chronic inflammation is often associated with alcoholrelated medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals, the adverse effects of LPS are kept in check by the actions and interactions of multiple organs. The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. The central nervous system contributes to anti-inflammatory regulation through neuroimmunoendocrine actions. Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. The study of these interactions may provide potential new targets for therapeutic intervention. | H Joe Wang Samir Zakhari M Katherine Jung | 2010 | World Journal of Gastroenterology2010，16，11： | 26 |
| 2 | Inflammation in Alcoholic Liver Disease显示文摘 | H. Joe Wang Bin Gao Samir Zakhari Laura E. Nagy | 2012 | Annual Review of Nutrition2012，，： | 3 |
| 3 | Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients显示文摘Clinical observations have demonstrated that excessive chronic alcohol use negatively affects human immuno- deficiency virus (HIV) infection and contributes to the liver manifestations of the disease, even in HIV mono- infection. HIV/hepatitis C virus (HCV) co-infection is as- sociated with increased progression of HVC liver disease compared to HCV infection alone, and both of these are negatively affected by alcohol use. Recent data suggest that alcohol use and HIV infection have common targets that contribute to progression of liver disease. Both HIV infection and chronic alcohol use are associated with increased gut permeability and elevated plasma levels of lipopolysaccharide; a central activator of inflammatory responses. Both alcoholic liver disease and HIV infec tionresult in non-specific activation of innate immunity, proinflammatory cytokine cascade upregulation, as well as impaired antigen presenting cell and dendritic cell functions. Finally, alcohol, HIV and antiretroviral therapyaffect hepatocyte functions, which contributes to liver damage. The common targets of alcohol and HIV infection in liver disease are discussed in this minireview. | Gyongyi Szabo Samir Zakhari | 2011 | World Journal of Gastroenterology2011，17，20： | 2 |
| 4 | Vascular endothelial growth factor level in chronic liver diseases 显示文摘 | Makhlouf MM Awad A Zakhari MM | 2002 | J Egypt Soc Parasitol2002，32，： | 1 |
| 5 | Delayed Versus Immediate Reconstruction of Mandibular Segmental Defects Using Recombinant Human Bone Morphogenetic Protein 2/Absorbable Collagen Sponge显示文摘 | Khaled A. Hussein Ibrahim E. Zakhary Dana Hailat Rami Elrefai Mohamed Sharawy Mohammed E. Elsalanty | 2013 | Journal of Oral and Maxillofacial Surgery2013，，6： | 1 |
| 6 | Targeted gene deletion of heme oxygenase-2 reveals neural role for carbon monoxide显示文摘 | Zakhary R Poss KD Jaffrey SR | 1997 | Proc Natl Acad Sci USA1997，94，14： | 1 |
| 7 | Heme oxygenase 2:endothelial and neuroal localization in endothelium-dependent relaxation显示文摘 | Gaine SP Dinerman JL | 1996 | Proc Natl Acad Sci USA1996，93，2： | 1 |
| 8 | Flouorimetric determination of aminoglycoside antibiotics using lanthanide probe iron spectroscopy显示文摘 | Rizk M EL-Shabrawy Y Zakhari N A | 1995 | Talanta1995，42，12： | 1 |
| 9 | Nitric oxide and carbon monoxide:parallel roles as neural messengers显示文摘 | Snyder SH Jaffrey SR Zakhary R | 1998 | Brain Res Rev1998，26，23： | 1 |
| 10 | Members of the miRNA-200 family regulate olfactory neurogenesis 显示文摘 | Choi PS Zakhary L Choi WY | 2008 | Neuron2008，57，1： | 1 |
| 11 | Determinants of alcohol use and abuse: impact of quantity and frequency patterns on liver disease显示文摘 | Zakhari S Li T K | 2007 | Hepatology2007，46，6： | 1 |
| 12 | New observations on microarchitecture of corpora cavernosa in man and possible relationship to mechanism of erection 显示文摘 | Goldstein AM Meehan JP Zakhary R | 1982 | Urology1982，20，3： | 1 |
| 13 | Alcohol and the cardiovascular system: molecular mechanism foe beneficial and harmful action 显示文摘 | Zakhari S | 1997 | Alcohol Health Res World1997，21，1： | 1 |
| 14 | Effect of recombinant human bone morphogenetic protein 7 on bone density during distraction osteogenesis of the rabbit mandible显示文摘 | Zakhary K Motakis D Hamdy RH | 2005 | Otolaryngol2005，34，6： | 1 |
| 15 | Spectrophoto-metric determination of aluminum and copper ions using SPADNS 显示文摘 | Rizk M Zakhari N A Toubar S S El-Shabrawy Y | 1995 | Mikrochimica Acta1995，118，： | 1 |
| 16 | Members of the miRNA-200 family regulate olfactory neurogenesis显示文摘 | Choi P S Zakhary L Choi W Y | 2008 | Neuron2008，57，1： | 1 |
| 17 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 18 | Difference in soft tissue response between immediate and delayed delivery suggests a new mechanism for recombinant human bone morphogenetic protein 2 action in large segmental bone defects显示文摘 | Hussein KA Zakhary IE Elawady AR | | 0，，5： | 1 |
| 19 | Oxidative stress in the contextofacute cerebrovascular stroke显示文摘 | EIKossi MM Zakhary MM | 2000 | Stroke2000，31，： | 1 |
| 20 | Oxidative stress in the context of acute cerebrov ascular stroke显示文摘 | Zakhary MM | 2000 | Stroke2000，31，8： | 1 |
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