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| 1 | Intestinal epithelial cells in inflammatory bowel diseases显示文摘The pathogenesis of inflammatory bowel diseases (IBDs) seems to involve a primary defect in one or more of the elements responsible for the maintenance of intestinal homeostasis and oral tolerance. The most important element is represented by the intestinal barrier, a complex system formed mostly by intestinal epithelial cells (IECs). IECs have an active role in producing mucus and regulating its composition; they provide a physical barrier capable of controlling antigen traff ic through the intestinal mucosa. At the same time, they are able to play the role of non-professional antigen presenting cells, by processing and presenting antigens directly to the cells of the intestinal immune system. On the other hand, immune cells regulate epithelial growth and differentiation, producing a continuous bi-directional cross-talk within the barrier. Several alterations of the barrier function have been identif ied in IBD, starting from mucus features up to its components, from epithelial junctions up to the Toll-like receptors, and altered immune responses. It remains to be understood whether these defects are primary causes of epithelial damage or secondary effects. We review the possible role of the epithelial barrier and particularly describe the role of IECs in the pathogenesis of IBD. | Giulia Roda Alessandro Sartini Elisabetta Zambon Andrea Calafiore Margherita Marocchi Alessandra Caponi Andrea Belluzzi Enrico Roda | 2010 | World Journal of Gastroenterology2010，16，34： | 12 |
| 2 | Diagnosis of influenza in the community:relationship of clinical diagnosis to confirmed virological,serologic,or molecular detection of influenza显示文摘 | Hays J Webster A | 2001 | Arch Inter Med2001，161，17： | 1 |
| 3 | Restrictions to the adaptation of influenza A virus H5 hemagglutinin to the human host显示文摘 | Harvey R Martin A C Zambon M | 2004 | J Virol2004，78，1： | 1 |
| 4 | Molecular basis of resistance of influenza A viruses to amantadine显示文摘 | Hay AJ Zambon MC Wolstenholme A J | 1986 | J Antimi- crob Chemother1986，18，： | 1 |
| 5 | Advantages and limitations of duckweed -based wastewater treatment systems 显示文摘 | Bonomo L Pastorelli G Zambon N | 1997 | Water SciTechnol1997，35，： | 1 |
| 6 | The evolution of norovirus, the“gastric flu”显示文摘 | Lopman B Zambon M Brown DW | 2008 | PLoS medicine2008，5，2： | 1 |
| 7 | Identification of periodontal pathogens in atheromatous plaques 显示文摘 | Haraszthy VI Zambon JJ Trevisan M | 2000 | J Periodon- tol2000，71，10： | 1 |
| 8 | Menopause hormone replacement therapy and cancer risk: an Italian record linkage investigation 显示文摘 | Corrao G Zambon A Conti V | 2008 | Ann Oncol2008，19，1： | 1 |
| 9 | Pro-and anti-inflammatory eytokines gene polymorphisms and Heli- cobacter pylori infection : interactions influence outcome 显示文摘 | CARLO-F ZAMBON DANIELA BASSO FILIPPO NAVAGLIA et al | 2005 | Cytokine2005，29，4： | 1 |
| 10 | Identification of pe- riodontal pathogens in atheromatous plaques显示文摘 | Harasztby VI Zambon JJ Trevisan M | 2000 | J Periodontol2000，71，10： | 1 |
| 11 | Influenza显示文摘 | Nicholson KG Wood JM Zambon M | 2003 | Lancet2003，362，9397： | 1 |
| 12 | The evolution of norovirus, the 'gastric flu' 显示文摘 | Lopman B Zambon M Brown DW | 2008 | PLoS Medi2008，5，： | 1 |
| 13 | Molecular diagnosis of influenza显示文摘 | ELLIS J S ZAMBON M C | 2002 | Rev Med Viol2002，12，6： | 1 |
| 14 | GenMAPP2: new features and resources for pathway analysis 显示文摘 | Salomonis N Hanspers K Zambon AC | 2007 | BMC Bioinformatics2007，8，： | 1 |
| 15 | The pathogenesis of influenza in humans 显示文摘 | Zambon MC | 2001 | Rev Med Virol2001，11，4： | 1 |
| 16 | Investigation of electron-beam welding in wrought Inconel 706-experimentaland numerical analysis显示文摘 | Ferro P Zambon A Bonollo F | 2005 | Materials Science and Engineering A2005，392，12： | 1 |
| 17 | Implementation of the Surviving Sepsis Campaign guidelines for severe sepsis and septic shock: we could go faster 显示文摘 | Zambon M Ceola M Almeida-De-Castro R | 2008 | J Crit Care2008，23，4： | 1 |
| 18 | A case-referent study in vestigating the relationship between exposure to silica dust and lung cancer显示文摘 | Mastrangels G Zambon P Simonato L | 1988 | Int Arch Occup Environ Health1988，60，4： | 1 |
| 19 | Identification of periodontal pathogens in atheromatous plaques 显示文摘 | Haraszthy VI Zambon JJ Trevisan M | 2000 | J Periodontol2000，71，10： | 1 |
| 20 | Implementation of the Surviving Sepsis Campaign guidelines for severe sepsis and septic shock:we could go faster显示文摘 | Zambon M Ceola M Almeida-de-Castro R | | 0，，4： | 1 |
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