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| 1 | Punctual mutations in 23S rRNA gene of clarithromycinresistant Helicobacter pylori in Colombian populations显示文摘AIM To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori(H. pylori) and determine their association with therapeutic failure.METHODS PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin(29 from a low-risk gastric cancer(GC) population: TumacoColombia, and 5 from a high-risk population: TuquerresColombia) and 40 from a susceptible population(28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis. The concordance between mutations of V domain 23S rRNA gene of H. pylori and therapeutic failure was determined using the Kappa coefficient and Mc Nemar's test was performed to determine the relationship between H. pylori mutationsand clarithromycin resistance.RESULTS23S rRNA gene from H. pylori was amplified in 56/74 isolates, of which 25 were resistant to clarithromycin(20 from Tumaco and 5 from Túquerres, respectively). In 17 resistant isolates(13 from Tumaco and 4 from Túquerres) the following mutations were found: A1593 T1, A1653 G2, C1770 T, C1954 T1, and G1827 C in isolates from Tumaco, and A2144 G from Túquerres. The mutations T2183 C, A2144 G and C2196 T in H. pylori isolates resistant to clarithromycin from Colombia are reported for the first time. No association between the H. pylori mutations and in vitro clarithromycin resistance was found. However, therapeutic failure of eradication treatment was associated with mutations of 23S rRNA gene in clarithromycin-resistant H. pylori(κ = 0.71).CONCLUSION The therapeutic failure of eradication treatment in the two populations from Colombia was associated with mutations of the 23S rRNA gene in clarithromycinresistant H. pylori. | Andrés Jenuer Matta Diana Carolina Zambrano Alvaro Jairo Pazos | 2018 | World Journal of Gastroenterology2018，24，14： | 5 |
| 2 | A single subcutaneous dose of tramadol for mild to moderate musculoskeletal trauma in the emergency department显示文摘BACKGROUND: Mild to moderate musculoskeletal trauma is a common cause for an emergency room visit, and frequent pain is one of the cardinal symptoms of consultation. The objective of this study is to assess the perception of a single subcutaneous dose of 50 mg tramadol for pain management in patients with mild to moderate musculoskeletal trauma, likewise to appraise the perception of pain by subcutaneous injection.METHODS: A total of 77 patients, who met inclusion criteria, received a single subcutaneous dose of tramadol. Pain control was evaluated based on the verbal numerical pain scale(0–10) at baseline, 20 and 60 minutes; similarly, pain perception was evaluated secondary to subcutaneous injection of the analgesic.RESULTS: On admission, the average pain perceived by patients was 8; twenty minutes later, 89% of the patients reported fi ve or less, and after sixty minutes, 94% had three or less on the verbal numerical pain scale. Of the patients, 88% reported pain perception by verbal numeric scale of 3 or less by injection of the drug, and 6.5% required a second analgesic for pain control. Two events with drug administration(soft tissue infection and mild abdominal rectus injection) were reported.CONCLUSION: We conclude that a single subcutaneous dose of tramadol is a safe and effective option for the management of patients with mild to moderate pain and musculoskeletal disease in the emergency department. | Alejandro Cardozo Carlos Silva Luis Dominguez Beatriz Botero Paulo Zambrano Jose Bare?o | 2014 | World Journal of Emergency Medicine2014，5，4： | 2 |
| 3 | Bone Marrow Mesenchymal Stem Cells Stimulate Cardiac Stem Cell Proliferation and Differentiation显示文摘 | Konstantinos E. Hatzistergos Henry Quevedo Behzad N. Oskouei Qinghua Hu Gary S. Feigenbaum Irene S. Margitich Ramesh Mazhari Andrew J. Boyle Juan P. Zambrano Jose E. Rodriguez Raul Dulce Pradip M. Pattany David Valdes Concepcion Revilla Alan W. Heldman Ia | 2010 | Circulation Research2010，，7： | 2 |
| 4 | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved显示文摘The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. | Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 5 | Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH -SY5Y cells 显示文摘 | De los Santos M Zambrano A Aranda A | 2007 | Mol Cancer Ther2007，6，4： | 1 |
| 6 | Interlekin-3 prevents neuronal death induced by amyloid peptide显示文摘 | Zambrano A 0tth C Mujica L | 2007 | BMC Neurosci2007，8，： | 1 |
| 7 | Sliding mode predictive control of a solar air conditioning plant显示文摘 | Winston Garcia-Gabin Darine Zambrano Eduardo F. Camacho | 2008 | Control Engineering Practice2008，，6： | 1 |
| 8 | Expression of rotavirus induces changes in Ca^2 + homeostasis in cultured cells 显示文摘 | Zambrano JL Diaz Y Pena F | 2008 | J Virol2008，82，12： | 1 |
| 9 | A phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes显示文摘 | ZAMBRANO P SEGURA-PACHECO B PEREZ-CARDENAS E | 2005 | BMC Cancer2005，5，1： | 1 |
| 10 | Experimental broodstock diets as partial fresh food substitutes in white shrimp Litopenaeus vannamei B 显示文摘 | Wouters R Zambrano B Espin M | 2002 | Aquaculture Nutrition2002，7，： | 1 |
| 11 | Selection of sugarcane plants resistant to SCMV显示文摘 | Zambrano A Y Demey J R Fuchs M | 2003 | Plant Science2003，165，： | 1 |
| 12 | The epi-demiology of dengue in the Americas over the last threedecades:a worrisome reality显示文摘 | San Martin JL Brathwaite O Zambrano B | 2010 | Am J Trop Med Hyg2010，82，1： | 1 |
| 13 | Isolated noncompaction of the ventricular myocardium:clinical and molecular aspects of a rare cardiomyopathy显示文摘 | Zambrano E Marshalko SJ Jaffe CC | | 0，，： | 1 |
| 14 | Aortic pressure augmentation predicts adverse cardiovascular events in patients with established coronary ar- tery disease 显示文摘 | Chirinos JA Zambrano JP Chakko S | 2005 | Hypertension2005，45，： | 1 |
| 15 | Primary and Reversible Pisa Syndrome in Juvenile Normal Pressure Hydrocephalus 显示文摘 | Leon-Sarmiento FE Pradilla G Del Rosario Zambrano M | 2013 | Aeta Neuropsyehiatr2013，25，1： | 1 |
| 16 | Isolated Noneompaction of the Ventrieular Myocardium:Clinica and Molecular Aspects of a Rare Cardio myopathy显示文摘 | Marshalko S Jafe C | 2002 | laboratory investigation2002，82，2： | 1 |
| 17 | Microstructural Analysis of Hot - rolled Low - carbon Steel Strips显示文摘 | Zambrano PC Guerrero MP Colas R | 2001 | Materials Characterization2001，47，34： | 1 |
| 18 | Endocrine disruptor compounds and their role on the developmental programming of the reproductive axis显示文摘 | Guzmán C Zambrano E | 2007 | Rev Invest Clin2007，59，1： | 1 |
| 19 | Chromo-somal rearrangements in lipofibromatosis 显示文摘 | Kenney B Richkind K E Friedlaender G Zambrano E | 2007 | Cancer Genet Cyto-genet2007，179，2： | 1 |
| 20 | Experimental rhinoviruschallenges in adults with mild asthma:response to infection in relationto lgE显示文摘 | Zambrano JC Carper HT Rakes CP | 2003 | J Allergy Clin Immunol2003，111，5： | 1 |
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