|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease显示文摘AIM:To explore the association between hepatocellular carcinoma(HCC) and type 2 diabetes mellitus, describe the temporal relations between the onset of diabetes and the development of HCC and evaluate the possible effects of antidiabetic therapy on HCC risk.METHODS:We recruited 465 HCC patients, 618 with cirrhosis and 490 control subjects.We evaluated the odds ratio(OR) for HCC by univariate and multivariate analysis.Moreover, OR for HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were calculated.RESULTS:The prevalence of diabetes mellitus was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in the Control group.By univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12(CI 2.2-4.4, P < 0.001) and 2.2(CI 1.2-4.4, P = 0.01).In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of HCC.Moreover, we report an OR for HCC of 2.99(CI 1.34-6.65, P = 0.007) in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33(CI 0.1-0.7, P = 0.006) in diabetic patients treated with metformin.CONCLUSION:Our study confi rms that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC patients.Moreover, in male patients with type 2 diabetes mellitus, our data shows a direct association of HCC with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy. | Valter Donadon Massimiliano Balbi Michela Ghersetti Silvia Grazioli Antonio Perciaccante Giovanni Della Valentina Rita Gardenal Maria Dal Mas Pietro Casarin Giorgio Zanette Cesare Miranda | 2009 | World Journal of Gastroenterology2009，15，20： | 23 |
| 2 | Symposia Report Immunoglobulin G for the Treatment of Chronic Pain:Report of an Expert Workshop显示文摘背景:慢性疼痛的治疗效果仍不理想。尽管现在治疗慢性疼痛的药物种类较多,但许多患者对疗效仍不满意或诉药物的副作用太大。越来越多的证据表明,免疫系统参与了伤害性和神经病理性慢性疼痛的病理过程。设计:在英国利物浦的专题会议上,专家们出示了免疫系统参与慢性疼痛的证据。近来的研究表明,静脉(IVIg)或皮下(SCIg)注射免疫调节药物——多价免疫球蛋白(Ig G)可缓解外周神经病理性疼痛和其他疼痛性疾病。专题会议讨论了IVIg和SCIg治疗的适应证、效价比及其副作用。结果:Ig G可缓解某些伤害性和神经病理性慢性疼痛,如糖尿病、干燥综合征、纤维肌痛症、复杂性区域疼痛综合征、小儿麻痹后遗症和继发于病理性自身抗体的疼痛。结论:Ig G对某些慢性疼痛具有一定的治疗前景。Ig G是一种相对安全的治疗方法,副作用少而轻,但价格较贵。今后有必要对Ig G治疗顽固性疼痛进行随机对照研究和预测性临床试验。 | Stefano Tamburin Kristian Borg Xavier J. Caro Stefano Jann Alexander J. Clark Francesca Magrinelli Gen Sobue Lars Werhagen Giampietro Zanette Haruki Koike Peter J. Spath Angela Vincent Andreas Goebel | 2014 | 中国疼痛医学杂志2014，20，11： | 3 |
| 3 | Self-assembled Silica Gel Networks 显示文摘 | Wang J Pamidi P V A Zanette D R | 1998 | J Am Chem Sco1998，120，： | 2 |
| 4 | Dynamics of rumor propagation on small-world networks显示文摘 | ZANETTE Damia'n H | 2002 | Physical Review E2002，65，041908104190： | 1 |
| 5 | Transcranial Doppler in spontaneous attacks of migraine显示文摘 | Zanette EM Agnoli A Robarti C | 1992 | Stroke1992，23，5： | 1 |
| 6 | Neuropathic pain: diagnosis and treatment显示文摘 | Magrinelli F Zanette G Tamburin S | 2013 | Pract Neurol2013，13，： | 1 |
| 7 | Effects of urbanization on Neotropical wasp and bee assemblages in a Brazilian metropolis显示文摘 | ZANETTE L R MARTINS R P RIBEIRO S P | 2005 | Landscape and Urban Planning2005，71，24： | 1 |
| 8 | Critical behavior of propagation on small- world networks 显示文摘 | Zanette D H | 2001 | Physical Review E2001，64，05： | 1 |
| 9 | Dynamics of rumour propagation on small-world networks 显示文摘 | Zanette D H | 2002 | Physical Keview E2002，，65： | 1 |
| 10 | Macroscopic current in fractional anomous diffusion显示文摘 | ZANETTE D H | 1998 | Physica A1998，252，： | 1 |
| 11 | Dynamics of rumor propagation on smallworld networks显示文摘 | Zanette D H | 2002 | Physical Review E2002，65，04： | 1 |
| 12 | MiRNA expression profiles in chronic lympocytic and acute lymphocytic leukemia显示文摘 | Zanette DL Rivadavia F Molfetta GA | | 0，，11： | 1 |
| 13 | Critical Behavior of Propagation on Small- world Networks显示文摘 | Zanette D H | 2001 | Physical Review E2001，64，4： | 1 |
| 14 | Electronic dental anaesthesia for third inferior mo- lar surgery 显示文摘 | Zanette G Faceo E | 2007 | Minerva Stomato12007，56，5： | 1 |
| 15 | Ecodesign methods focused on remanufacturing 显示文摘 | PIGOSSO D C A ZANETTE E T FILHO A G | 2010 | Journal ofCleanerProduction2010，18，1： | 1 |
| 16 | Different mechanisms contribute to motor cortex hyperex- citability in amyotrophic lateral sclerosis显示文摘 | ZANETTE G TAMBURIN S MANGANOTrI P | 2002 | Clin Neurophysiol2002，113，11： | 1 |
| 17 | Critical behavior of propagation on small-world networks显示文摘 | ZANETTE D H | 2001 | Physical Review E2001，64，1： | 1 |
| 18 | Dynamics of rumor propagation on small-world networks显示文摘 | ZANETTE D H | 2002 | Physical Review E2002，65，4： | 1 |
| 19 | Central sensitization in carpal tun- nel syndrome with extraterritorial spread of sensory symptom 显示文摘 | Zanett G Cacciatori C Tamburin S | 2010 | Pain2010，148，： | 1 |
| 20 | In vitro activity of terbinafine associated to amphotericin B, fluvastatin,rifampicin, metronidazole and ibuprofen against Pythium insidiosum显示文摘 | Cavalheiro AS Zanette RA Spader TB | 2009 | Vet Microbiol2009，137，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员