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| 1 | Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis显示文摘The use of norfloxacin either as primary or secondary prophylaxis of bacterial infections in advanced cirrhosis has improved patient's survival. This may be explained not only due to a significant decrease in the number of infections, but also because of a direct immunomodulatory effect. Selective intestinal decontamination with norfloxacin reduces translocation of either viable bacteria or bacteria-driven products from the intestinal lumen. In addition, norfloxacin directly modulates the systemic inflammatory response. The proinflammatory cytokine profile secreted by neutrophils from these patients shows a close, significant, and inverse correlation with serum norfloxacin levels. Similar effects have been described with other quinolones in different clinical conditions. Although the underlying mechanisms are not well defined for most of the antibiotics, the pathways triggered for norfloxacin to induce such immunomodulatory effects involve the down-regulation of pro-inflammatory inducible nitric oxide synthase, cyclooxygenase-2, and NF-κB and the up-regulation of heme-oxygenase 1 and IL-10 expression. The knowledge of these immunomodulatory effects, additional to their bactericidal role, improves our comprehension of the interaction between antibiotics and the cellular host response and offer new possibilities for the development of new therapeutic strategies to manage and prevent bacterial infections in cirrhosis. | Pedro Zapater José Manuel González-Navajas José Such Rubén Francés | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 2 | Bacterial DNA Induces the Complement System Activation in Serum and Ascitic Fluid from Patients with Advanced Cirrhosis显示文摘 | Rubén Francés José M. González-Navajas Pedro Zapater Carlos Mu?oz Rocío Ca?o Sonia Pascual Dorkas Márquez Francia Santana Miguel Pérez-Mateo José Such | 2007 | Journal of Clinical Immunology2007，，4： | 2 |
| 3 | Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘 | Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés | 2014 | Liver Int2014，，6： | 2 |
| 4 | Differential ex- pression of putative 9-cisepoxycarotenoid dioxygenas- es and abscisic acid accumulation in water stressed vegetative and reproductive tissues of citrus 显示文摘 | Agusti J Zapater M Iglesias DJ | 2007 | Plant Science2007，172，1： | 1 |
| 5 | Tissue plas- minogen activator induces pancreatic cancer cell prolif- eration by a non - catalytic mechanism that requires ex- tracellular signal -regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2 显示文摘 | Ortiz -Zapater E Peiro S Roda O | 2007 | Am J Pathal2007，170，5： | 1 |
| 6 | A longitudinal study of intestinal calcium absorption during pregnancy and lactation in women with low calcium intakes显示文摘 | Vargas Zapate CL Donangelo CM Abrams SA | 2000 | Fed Proc2000，14，： | 1 |
| 7 | Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study显示文摘 | Enrique de-Madaria José María Palazón Flavia Tamara Hernández José Sánchez-Paya Pedro Zapater Javier Irurzun Francisco de Espa?a Sonia Pascual José Such Laura Sempere Fernando Carnicer Antonio García-Herola Jaime Valverde Miguel Pérez-Mateo | 2010 | European Journal of Gastroenterology & Hepatology2010，，5： | 1 |
| 8 | Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites显示文摘 | José Such Rubén Francés Carlos Mu?oz Pedro Zapater Juan A. Casellas Ana Cifuentes Francisco Rodr??guez-Valera Sonia Pascual Javier Sola-Vera Fernando Carnicer Francisco Uceda José M. Palazón Miguel Pérez-Mateo | 2002 | Hepatology2002，，1： | 1 |
| 9 | Comparison of staging systems to predictsurvival in hepatocellular carcinoma显示文摘 | Pascual S Zapater P Such J | 2006 | Liver Int2006，26，1： | 1 |
| 10 | A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites显示文摘 | Frances R Benlloch S Zapater P | 2004 | Hepatology2004，39，2： | 1 |
| 11 | Hepatotoxicity related to paraquat and diquat absorption through intact skin显示文摘 | Peiro AM Zapater P Alenda C | 2007 | Dig Dis Sci2007，52，11： | 1 |
| 12 | A new Poisson and Bayesian-based method to assign risk and causality in patients with suspected hepatic adverse drug reactions: a report of two new cases of ticlopidine-induced hepatotoxicity 显示文摘 | Zapater P Such J Pérez-Mateo M | 2002 | Drug Saf2002，25，10： | 1 |
| 13 | Generation of ESTs in Vitis vinifera wine grape (Cabernet Sauvignon) and table grape (Muscat Hamburg) and discovery of new candidates genes with potential roles in berry development 显示文摘 | PENG F Y REID K E LIAO N SCHLOSSER J LIJAVETZKY D HOLT R ZAPATER M JONES S MARRA M BOHLMANN J LUND S T | 2007 | Gene2007，402，： | 1 |
| 14 | Neuroprotection by the novel calcium antagonist PCAS0938, nimodipine and flunarizine, in gerbil global brain ischemia显示文摘 | Zapater P Z Moreno J Horga J F | 1997 | Brain Res1997，772，12： | 1 |
| 15 | Analysis of DNA methylation in Arabi- dopsis thaliana based on methylation-sensitive AFLP markers显示文摘 | CERVARA M T RUIN -GARCIA L MARTINEZ- ZAPATER J M | 2002 | Mol Genet Genomics2002，268，4： | 1 |
| 16 | AtREMI,a member of a new family of B3 domaincontaining genes,is preferentially expressed in reproductive meristems显示文摘 | Franco-Zorrilla J M Cubas P Jarillo J A Calvin B F Salinas J Zapater J M M | 2002 | Plant Physiol2002，128，： | 1 |
| 17 | Founder effects and stochastic dispersal at the continental scale of the fungal pathogen of bananas Mycosphaerella fijiensis显示文摘 | Riacas GG Zapater M F Abadie C | 2004 | Molecular Ecology2004，13，： | 1 |
| 18 | Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites显示文摘 | Frances -R Munoz -C Zapater -P | 2004 | Gut2004，53，6： | 1 |
| 19 | A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites显示文摘 | Frances -R Benlloch -S Zapater -P | 2004 | Hepatology2004，39，2： | 1 |
| 20 | Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites 显示文摘 | Frances R Munoz C Zapater P | 2004 | Gut2004，53，6： | 1 |
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