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| 1 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 2 | Positive and negative effects of thalidomide on refractory cutaneous lupus erythematosus显示文摘 | Briani C Zara G Rondinone R | 2005 | Autoimrnunity2005，38，7： | 1 |
| 3 | Service Quality Evaluation Models Determined by Online Consumer Perception and Satisfacion显示文摘 | Maria-Cristiana Munthiu Bogdan C fin Velicu Mihaela Tu Adina lulia Zara | 2014 | Procedia - Social and Behavioral Sciences2014，，12： | 1 |
| 4 | Cytoglobin and neuroglo- bin in the human brainstem and carotid body显示文摘 | Di Giulio C Zara S De Colli M | 2013 | Adv Exp Med Biol2013，788，： | 1 |
| 5 | Cancer pain and psychosocial factors: a critical review of the literature显示文摘 | Zara C Baine N | 2002 | J Pain Symptom Manage2002，24，5： | 1 |
| 6 | RANK/RANKL/OPG signaling pathways innecrotic jaw bone from bisphosphonate-treated subjects显示文摘 | Di Nisio C Zizzari VL Zara S | 2015 | Eur J Histochem2015，59，1： | 1 |
| 7 | Positive and negative effects of thalidomide on refractory cutaneous lupus erythematosus显示文摘 | Briani C Zara G Rondinone R | 2005 | Autoimmunity2005，38，7： | 1 |
| 8 | NOS- mediated morphological and molecular m(xtifieations in rts infused with AI3 (1 -40),as a model of Mzheimers disetr,e,in response to a new lifxphilie molecular eondination eodrug - 1 显示文摘 | Zara S Di Stefano A Nasuti C | 2011 | Exp Geronto12011，46，4： | 1 |
| 9 | An open-label trial of levetiracetam in severe myoclonic epilepsy of infancy显示文摘 | P Striano A Coppola M Pezzella C Ciampa N Specchio F Ragona M M. Mancardi E Gennaro F Beccaria G Capovilla P Rasmini D Besana G G. Coppola M Elia T Granata M Vecchi F Vigevano M Viri R Gaggero S Striano F Zara | 2007 | Neurology2007，，3： | 1 |
| 10 | Sjogren's syndrome associated with systemic lupus erythematosus : clinical and laboratory profiles and comparison with primary SjCigren's syndrome 显示文摘 | Manoussakis MN Georgopoulou C Zin/zaras E el al | 2004 | Arthritis Rheum2004，50，3： | 1 |
| 11 | Geometric Skinning with Approximate Dual Quaternion Blending 显示文摘 | Kavan L Collins S Zara J O'Sullivan C | 2008 | ACM Transactions on Graphics (S0730-0301)2008，27，4： | 1 |
| 12 | Determination of mercury in agroindustrial samples by flow-injection cold vapour atomic absorption spectrometry using ion exchange and reductive elution显示文摘 | Gomes N J A Zara L F Rocha J C | 2000 | Talanta2000，51，3： | 1 |
| 13 | Animal Models for Target Diseases inGene Therapy-using DNA and siRNA Delivery Strategies显示文摘 | Blagbrough I S Zara C | 2009 | Pharmaceu-tical Research2009，26，1： | 1 |
| 14 | 查看详情显示文摘 | Rocha J C Sargentini E Zara L F | | 0，，05： | 1 |
| 15 | Real-time bladder-layer recognition: an approach to optical biopsy显示文摘 | Lingley-Papadopoulos C A Loew M H Zara J M | 2007 | ISBI2007，，： | 1 |
| 16 | Reduction of mercury (Ⅱ) by tropical river humic substances ( Rio Negro) -a possible process of the mercury cycle in Brazil 显示文摘 | Rocha J C Junior E S Zara L F | 2000 | Talanta2000，53，3： | 1 |
| 17 | Animal Models for Target Diseases in Gene Therapyusing DNA and siRNA Delivery Strategies显示文摘 | fan SB Zara C | 2009 | Pharmaceutical Research2009，26，1： | 1 |
| 18 | Positive and negative effects of thalidomide on refractory cutaneous lupus erythematosus 显示文摘 | Briani C Zara G Rondinone R | 2005 | Autoimmunity2005，38，7： | 1 |
| 19 | Application pf of high spectral resolution spectroradiometry to vegetation显示文摘 | Ferns D C Zara S J Barber J | | 0，，： | 1 |
| 20 | Positive and negative effeets of thalidomide on refraetory eutaneous lupus erythematosus 显示文摘 | BRIANI C ZARA G RONDINONE R | 2005 | Autoimmunity2005，38，7： | 1 |
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