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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Wnt signaling controls the phosphorylation status of beta-catenin显示文摘 | van Noort M Meeldijk J van der Zee R el al | | 0，，： | 2 |
| 3 | A new technique of reversibly adsorbed phosphate显示文摘 | Fokkink L G J Van Reimsdijk W H | 1987 | Soil Sci Soc Am J1987，51，： | 1 |
| 4 | Diffusion and chemical activity of Zr-Sn and Zr-Ti systems 显示文摘 | ZEE R H WATTERS J F DAVIDSON R D | 1986 | Physical Review B1986，34，10： | 1 |
| 5 | Use of combined radiation and hyperthermia for gynecological cancer 显示文摘 | Franckena M van der Zee J | 2010 | Current Opinion in Obstetrics and Gynecology2010，22，1： | 1 |
| 6 | Alkalinization of urine samples preserves albumin concentrations during prolonged frozen stor- age in patients with diabetes mellitus 显示文摘 | Lambers Heerspink H J Nauta FL van der Zee CP | 2009 | Diabet Med2009，26，5： | 1 |
| 7 | Inte- gration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers 显示文摘 | Da X Toledo JB Zee J | 2014 | Neuroimage Clin2014，4，： | 1 |
| 8 | Long-term survival data of triple modality treatment of stage IIB-III- IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia-an update显示文摘 | Westermann A Mella O Van Der Zee J | 2012 | Int J Hyper- thermia2012，28，6： | 1 |
| 9 | The impact of chan- nel path length on PEMFC flow-field design显示文摘 | SHIMPALEE S GREENWAY S ZEE J W V | 2006 | Journal of Power Sources2006，160，： | 1 |
| 10 | Multi-phase flow modeling of air sparging显示文摘 | Van Dijke M Van der Zee I J Van Duijn C J | 1995 | Advances in Water Resources1995，18，6： | 1 |
| 11 | The Effects of Compression and Gas Diffusion Layers on the Performance of a PEM Fuel Cell显示文摘 | Woo-kum Lee Chien-Hsien Ho Van Zee J W | 1999 | Journal of Power Sources1999，84，： | 1 |
| 12 | Temperature data analysis for 22 patients with advanced cervical carcinoma treated in Rotterdam using radiotherapy,hyperthermia and chemotherapy:a reference point is needed显示文摘 | Fatehi D Van der Zee J Van der Wal E | 2006 | Int J Hyperthermia2006，22，4： | 1 |
| 13 | Wnt signaling controls the phosphorylation status of beta-catenin显示文摘 | Van Noort M Meeldijk J van der Zee R | 2002 | J Biol Chem2002，277，20： | 1 |
| 14 | Temperature data analysis for 22 patients with advanced cervical carcinoma treated in Rotterdam using radiotherapy, hyperthermia and chemotherapy: a reference point is needed显示文摘 | Fatehi D van der Zee J van der Wal E | 2006 | Int J Hyperthermia2006，22，4： | 1 |
| 15 | Evidence based selection of housekeeping genes显示文摘 | de Jonge H J Fehrmann R S de Bont E S Hofstra R M Gerbens F Kamps W A de Vries E G van der Zee A G te Meerman G J ter Elst A | | 0，，： | 1 |
| 16 | Single treatment approaches to benign paroxysmal positional vertigo显示文摘 | HERDMAN S J TUSA R J ZEE D S | 1993 | Arch Otolaryngol Head Neck Surg1993，119，： | 1 |
| 17 | The effects of compression and gas diffusion layers on the performance of a PEM fuel cell 显示文摘 | Lee Wk Ho C H Zee J W V | 1999 | Journal of Power Sources1999，84，： | 1 |
| 18 | Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family显示文摘 | Brouwers N Nuytemans K van der Zee J | 2007 | Arch Neurol2007，64，10： | 1 |
| 19 | NT -pro - BNP is associated with inducible myocardial ischemia in mildly symptomatic type 2 diabetic patients显示文摘 | Wiersma J J van der Zee PM van Straalen JP | 2010 | lnt J Cardiol2010，145，2： | 1 |
| 20 | Combined use of hyperthermia and radiation therapy for treating locally ad- vanced cervical carcinoma 显示文摘 | Lutgens L van der Zee J Pijls-Johannesma M | 2010 | Cochrane Database Syst Rev2010，，1： | 1 |
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