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| 1 | Gene editing and its applications in biomedicine显示文摘The steady progress in genome editing, especially genome editing based on the use of clustered regularly interspaced short palindromic repeats(CRISPR) and programmable nucleases to make precise modifications to genetic material, has provided enormous opportunities to advance biomedical research and promote human health. The application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability. Here, we provide a general summary of emerging biomedical applications of genome editing, including open challenges. We also summarize the tools of genome editing and the insights derived from their applications, hoping to accelerate new discoveries and therapies in biomedicine. | Guanglei Li Xiangyang Li Songkuan Zhuang Liren Wang Yifan Zhu Yangcan Chen Wen Sun Zeguang Wu Zhuo Zhou Jia Chen Xingxu Huang Jin Wang Dali Li Wei Li Haoyi Wang Wensheng Wei | 2022 | Science China(Life Sciences)2022，65，4： | 8 |
| 2 | A transient multiphysics coupling method based on OpenFOAM for heat pipe cooled reactors显示文摘Differing from traditional pressurized water reactors(PWRs),heat pipe cooled reactors have the unique characteristics of fuel thermal expansion,expansion reactivity feedback,and thermal contact conductance.These reactors require a new multiphysics coupling method.In this paper,a transient coupling method based on OpenFOAM is proposed.The method considers power variation,thermal expansion,heat pipe operation,thermal contact conductance,and gap conductance.In particular,the reactivity feedback caused by working medium redistribution in a heat pipe is also preliminarily considered.A typical heat pipe cooled reactor KRUSTY(Kilowatt Reactor Using Stirling TechnologY)is chosen as the research object.Compared with experimental results of load following,the calculated results are in good agreement and show the validity of the proposed method.To discuss the self-adjusting capability of this type of reactor system,a hypothetical accident is simulated.It is assumed that at the beginning of this accident,loss of the heat sink occurs.After 1500 s of the transient process,the reactor system recovers immediately.During this hypothetical accident,the control rod is always out of the reactor core,and the reactor only relies on the reactivity feedback to regulate the fission power.According to the simulation,the peak temperature is only about 1112 K,which is far below the safety limit.As for system recovery,the reactor needs approximately 2500 s to return to a steady state and can realize effective power regulation by reactivity feedback.This study confirms the availability of this coupling method and that it can be an effective tool for the simulation of heat pipe cooled reactors. | GUO YuChuan LI ZeGuang WANG Kan SU ZiLin | 2022 | Science China(Technological Sciences)2022，65，1： | 4 |
| 3 | Demographic change, savings, investment, and economic growth显示文摘 | Xing Li Zeguang Li | 2012 | The Chinese Economy2012，，45： | 1 |
| 4 | Significant flow velocity reduction at the intracranial aneurysm neck after endovascular treatment leads to favourable angiographic outcome:a prospective study显示文摘Background With widely usage of flow diverter in intracranial aneurysm treatment,some previously used predictors may not be effective in evaluating the recurrence risk.We aimed to comprehensively re-evaluate the predictors of intracranial aneurysm outcome with various endovascular treatment methods and devices.Methods This is a prospective registered study.We analysed 6-month and 18-month follow-up angiographic data from the prospective study.Data on patient demographics,aneurysm morphology and type of treatment were recorded.Patient-specific haemodynamic simulations were performed.An unfavourable angiographic outcome was defined as recurrence of aneurysm in cases with coiling or stent-assisted coiling,patency of aneurysm in cases with flow diverters or retreatment during follow-up.Results In total,165 patients(177 intracranial aneurysms)with at least one angiographic follow-up data were analysed.For the short-term(6-month)results,after univariate analysis,the demographic,morphological and treatment-related factors did not achieve significantly statistical differences.The reduction ratio(RR)of velocity at aneurysm neck after embolisation was significantly lower in the unfavourable angiographic group than the favourable angiographic outcome group(p=0.002).After the Cox regression analysis,the RR of velocity at aneurysm neck was the only independent factor associated with favourable angiographic outcome(OR 0.028;p=0.001)and had an acceptable area under the curve(0.714)with a clear cut-off value(46.14%).Similarly,for the analysis of midterm(18-month)results,the RR of velocity at the aneurysm neck was the only independent significant factor for the unfavourable angiographic outcome(OR 0.050;p=0.017).The area under the curve was 0.754 and the cut-off value was 48.20%.Conclusions The haemodynamics showed an independent effect on angiographic follow-up results and may provide helpful suggestions for clinical practice in the future. | Zhongbin Tian Jian Liu Jay Kumar Wenqiang Li Yisen Zhang Ying Zhang Kun Wang Shengzhang Wang Zeguang Ren Xinjian Yang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 5 | siRNA mediated the type 1 insulin-like growth factor receptor and epidermal growth factor receptor silencing induces chemosensitization of liver cancer cells显示文摘 | Jian Niu Xiang-nong Li Haixin Qian Zeguang Han | 2008 | Journal of Cancer Research and Clinical Oncology2008，，4： | 1 |
| 6 | Developmentand benchmark validation of a new MC neutron transport codeRMC for reactor analysis显示文摘 | LI Zeguang WANG Kan SHE Ding | 2010 | Transaction of AmericanNuclear Society2010，103，： | 1 |
| 7 | A study of spray granulation in vibrated fluidized bed with internal heating tubes显示文摘The granulation process in a vibratedfluidized bed with immersed horizontal heating tubes was studied in this paper,with small monoammonium phosphate particles as the initial particles and monoammonium phosphate solution sprayed on them.The concrete influences on the granulating performance of the immersed horizontal heating power,fluidizing gas velocity,vibration frequency and amplitude had been analyzed theoretically.The results show that appropriate vibration intensity is a preferred condition for the growth of partials,but thefine dust will become much more along with prolonged vibration.Increasing the heating power is beneficial to raise the growth rate.Particles will grow faster if thefluidizing gas velocity is higher,but this will cause morefine dust.The optimized condition of A=0.002 m,f=6.67 Hz,u=1.4 m/s was given after the analysis of the experimental results.In the end,a semiempirical formula was derived from the experiment data,and the calculation results show good agreement with the experimental data. | Xiaoheng PAN Shichao YE Zeguang ZHANG Li ZHANG Xuejun ZHU | 2009 | Frontiers of Chemical Science and Engineering2009，3，1： | 0 |
| 8 | 靶向IGF1R的siRNA抑制人肝癌细胞SMMC7721裸鼠移植瘤的实验研究(英文)显示文摘调查像胰岛素的生长因素 1 受体(IGF1R ) 的效果的目的在裸体老鼠的人的肝癌症 SMMC7721 房间异种皮移植的生长上的小介入 RNA (siRNA ) 。指向 IGF1R 的方法 siRNA 被设计,并且原生质标志 SMMC7721-IGF1R-siRNA 被构造并且 transfected 进 SMMC7721 房间(SMMC7721-IGF1R-siRNA 房间) ;有 SMMC7721-IGF1R-mutation (SMMC7721-IGF1R-mutation 房间) 的房间 transfected 作为空控制被用作否定控制,和 untransfected 房间。稳定的房间克隆被 G418 屏蔽,并且移植了进裸体老鼠建立癌症异种皮移植。肿瘤生长被监视。肿瘤形态学被观察与他染色。在肿瘤纸巾的 IGF1R 蛋白质的表示被西方的污点检测。在肿瘤纸巾的 Microvessel 密度(MVD ) 被 SP 免疫组织化学检测。房间 apoptosis 被终端 deoxynucleotidyl 检测调停 transferase 的 dUTP 刻痕标记结束(TUNEL ) 试金。结果肿瘤体积比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF1R-siRNA 组是显著地更小的(P <
0.05 ) 。坏死和房间 apoptosis 在 SMMC7721-IGF1R-siRNA 组被发现。IGF1R 蛋白质的表示比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF-1R-siRNA 组是显著地更低的(P <
0.05 ) 。MVD 比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF1R-siRNA 组是显著地更低的(11.3 ± 4.4 对 36.7 ± 7.6 和 28.4 ± 6.5, P <
0.05 ) 。肿瘤房间的 apoptosis 率比在 SMMC7721-IGF1R-mutation 和 SMMC7721 组在 SMMC7721-IGF1R-siRNA 组是显著地更高的[(50.2 ± 6.4 )% 对(5.4 ± 1.0 )% 或(6.0 ± 2.1 )% , P <
0.05 ] 。结论 IGF1R siRNA 能在裸体老鼠禁止 SMMC7721 细胞异种皮移植的生长。 | Jian Niu Haixin Qian Xiangnong Li Zeguang Han | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
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