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| 1 | Individualized prediction of perineural invasion in colorectal cancer: development and validation of a radiomics prediction model显示文摘Objective: To develop and validate a radiomics prediction model for individualized prediction of perineural invasion(PNI) in colorectal cancer(CRC).Methods: After computed tomography(CT) radiomics features extraction, a radiomics signature was constructed in derivation cohort(346 CRC patients). A prediction model was developed to integrate the radiomics signature and clinical candidate predictors [age, sex, tumor location, and carcinoembryonic antigen(CEA) level]. Apparent prediction performance was assessed. After internal validation, independent temporal validation(separate from the cohort used to build the model) was then conducted in 217 CRC patients. The final model was converted to an easy-to-use nomogram.Results: The developed radiomics nomogram that integrated the radiomics signature and CEA level showed good calibration and discrimination performance [Harrell's concordance index(c-index): 0.817; 95% confidence interval(95% CI): 0.811–0.823]. Application of the nomogram in validation cohort gave a comparable calibration and discrimination(c-index: 0.803; 95% CI: 0.794–0.812).Conclusions: Integrating the radiomics signature and CEA level into a radiomics prediction model enables easy and effective risk assessment of PNI in CRC. This stratification of patients according to their PNI status may provide a basis for individualized auxiliary treatment. | Yanqi Huang Lan He Di Dong Caiyun Yang Cuishan Liang Xin Chen Zelan Ma Xiaomei Huang Su Yao Changhong Liang Jie Tian Zaiyi Liu | 2018 | Chinese Journal of Cancer Research2018，30，1： | 23 |
| 2 | Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits. | Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu | 2014 | Neuroscience Bulletin2014，30，6： | 7 |
| 3 | Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species显示文摘Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex II.Chlorpropamide delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and mice.In addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP channels.Increased levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated worms.Moreover,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity signal.This study provides mechanistic insight into the anti-aging effects of sulfonylureas in C.elegans. | Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 4 | Evidence for Altered Numb Isoform Levels in Alzheimers Disease Patients and a Triple Transgenic Mouse Model显示文摘 | Srinivasulu Chigurupati Meenu Madan Eitan Okun Zelan Wei Jogi V. Pattisapu Mohamed R. Mughal Mark P. Mattson Sic L. Chan | 2011 | Journal of Alzheimers Disease2011，，： | 1 |
| 5 | 2D SiC/SiC composite for flow channel insert (FCI) application显示文摘 | Haijiao Yu Xingui Zhou Honglei Wang Shuang Zhao Yican Wu Qunying Huang Zhiqiang Zhu Zelan Huang | 2010 | Fusion Engineering and Design2010，，7： | 1 |
| 6 | P1-241 Aβ1-42 can kill murine N2A neuroblastoma cells at nanomolar concentration显示文摘 | Zhenfu Wang Zelan Wei X.-M. Li Luning Wang | 2004 | Neurobiology of Aging2004，，： | 1 |
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