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| 1 | Roles of P-glycoprotein and multidrug resistance protein in transporting para-aminosalicylic acid and its N-acetylated metabolite in mice brain显示文摘目的: Para-aminosalicylic 酸(舞步) 在导致 manganism 的 neurotoxicity (manganism ) 的处理是有效的。在这研究,我们在通过血大脑障碍搬运舞步和它的 N-acetylated 代谢物 AcPAS 调查了 P-glycoprotein (MDR1a ) 和 multidrug 抵抗蛋白质(MRP ) 的角色。 | Lan HONG Cong XU Stefanie O'NEAL Hui-chang BI Min HUANG Wei ZHENG Su ZENG | 2014 | Acta Pharmacologica Sinica2014，35，12： | 4 |
| 2 | Polysaccharide-based nanomedicines for cancer immunotherapy:A review显示文摘Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics.However,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)efficiency.To overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune response.Their structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues.This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics. | Yujun Zeng Yufan Xiang Ruilong Sheng Helena Tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo | 2021 | Bioactive Materials2021，6，10： | 3 |
| 3 | LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing. | ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui | 2020 | Biomedical and Environmental Sciences2020，33，11： | 2 |
| 4 | Time domain characterization of oscillating sensors:application of frequency counting to resonance frequency determination显示文摘 | ZENG K F KEAT G O CASEY M | 2002 | Review of Scientific Instruments2002，73，12： | 1 |
| 5 | Microglial activation in human diabetic retinopathy显示文摘 | ZENG H Y GREEN W R TSO M O | 2008 | Arch Ophthalmol2008，126，2： | 1 |
| 6 | Identification of associations between SSR markers and fiber traits in an exotic germplasm derived from multiple crosses among Gossypium tetraploid species显示文摘 | Zeng L H Meredith W R Jr Gutiérrez O A | 2009 | Theor Appl Genet2009，119，： | 1 |
| 7 | Frequency-domain characterization of magnetoelastic sensors:a microcontroller-based instrument for spectrum analysis using a threshold-crossing counting technique显示文摘 | ZENG K F MAGGIE P KEAT G O | 2005 | Sensors and Actuators A:Physical2005，121，1： | 1 |
| 8 | Detection of antibody to LAV/ HTLV-Ⅲ in sera from hemophiliacs in China显示文摘 | Zeng Y Fan J Zhang O | 1986 | AIDS Res1986，2，1： | 1 |
| 9 | Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosus cells of complementation groups A,B,and C显示文摘 | Quillet X Chevallier-Lagente O | 1997 | Gene Ther1997，4，： | 1 |
| 10 | IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor ceil lines显示文摘 | Zeng L O'Connor C Zhang J | 2010 | Cytokine2010，49，3： | 1 |
| 11 | Board level integrated microsystem design and associated technique for impedance analysis of resonator sensors显示文摘 | ZENG K F KEAT G O YANG X P | 2006 | Sensor Letters2006，4，4： | 1 |
| 12 | Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor-ERK pathway显示文摘 | Zeng O Chen GG Vlantis AC | 2007 | Cell Prolif2007，40，6： | 1 |
| 13 | Effects of substracte limi-tation on products distribution and H2/CO2 ratio in Klebsiella pneumoniae during anaerobic fermentation of glycerol显示文摘 | Solomon B O Zeng AP Biebl H | 1994 | Appl Microbiol Bioteehnol1994，42，3： | 1 |
| 14 | IL-IO promotes resistance to apoptosis and metastatic potential in lung tumor cell lines显示文摘 | Zeng L O'Connor C Zhang J | 2010 | Cytokine2010，49，3： | 1 |
| 15 | IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor cell lines 显示文摘 | Zeng L O'Connor C Zhang J | 2010 | Cytokine2010，49，3： | 1 |
| 16 | Implication of genetic variants near TMEM18,BCDIN3D/FAIM2,and MC4R with coronary artery disease and obesity in Chinese:A angiography-based study显示文摘 | Huang H Zeng Z Zhang L Liu R Li X Qiang O and Chen Y | | 0，，02： | 1 |
| 17 | IL-IO promotes resistance to apoptosis and metastatic potential in lung tumor cell lines 显示文摘 | Li Zeng O'Connor C Zhang J Y | 2010 | Cytokine2010，49，： | 1 |
| 18 | IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor cell lines显示文摘 | Zeng L O'Connor C Zhang J | 2010 | Cytokine2010，49，3： | 1 |
| 19 | J Hazard Mater显示文摘 | Gong J L Wang B Zeng O M Yang C P Niu C G Niu Q Y Zhou W J Liang Y | 2009 | 164(2-3):15172009，164，23： | 1 |
| 20 | Ezrin ptomotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis of ovarian carcinoma显示文摘 | K(o)bel M Gradhand E Zeng K | | 0，，02： | 1 |
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