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| 1 | FGF1^(△HBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression显示文摘As a classically known mitogen,fibroblast growth factor 1(FGF1)has been found to exert other pleiotropic functions such as metabolic regulation and myocardial protection.Here,we show that serum levels of FGF1 were decreased and positively correlated with fraction shortening in diabetic cardiomyopathy(DCM)patients,indicating that FGF1 is a potential therapeutic target for DCM.We found that treatment with a FGF1 variant(FGF1^(△HBS))with reduced proliferative potency prevented diabetes-induced cardiac injury and remodeling and restored cardiac function.RNA-Seq results obtained from the cardiac tissues of db/db mice showed significant increase in the expression levels of anti-oxidative genes and decrease of Nur77 by FGF1AHBS treatment.Both in vivo and in vitro studies indicate that FGF1^(△HBS) exerted these beneficial effects by markedly reducing mitochondrial fragmentation,reactive oxygen species(ROS)generation and cytochrome c leakage and enhancing mitochondrial respiration rate and β-oxidation in a 5;AMP-activated protein kinase(AMPK)/Nur77-dependent manner,all of which were not observed in the AMPK null mice.The favorable metabolic activity and reduced proliferative properties of FGF1^(△HBS) testify to its promising potential for use in the treatment of DCM and other metabolic disorders. | Dezhong Wang Yuan Yin Shuyi Wang Tianyang Zhao Fanghua Gong Yushuo Zhao Beibei Wang Yuli Huang Zizhao Cheng Guanghui Zhu Zengshou Wang Yang Wang Jun Ren Guang Liang Xiaokun Li Zhifeng Huang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 6 |
| 2 | Research on rapid development platform of PLC control system显示文摘In the field of industrial process control,a fast-development platform for programmable logic controller(PLC)systems is designed in order to solve two main problems of rapid development of PLC control system and programmability of controlling software.In the aspect of design,the platform is composed of hardware controlling and software monitoring and is taking industrial computer as the core.Under the Windows environment,the platform establishes the control instruction set,develops the configuration function and visual programming function of the monitoring software and it integrates PLC controller based on Visual Basic software.In order to achieve the function of data monitoring,it has realized the serial communication between computer and PLC by using RS-485 and RS-232 serial ports line communication.The platform designs the intelligent instruction scheduling strategy by studying the encoding and decoding rules of the communication instruction set.It proposes a method for rapidly developing control programs by adopting the expert control mode,which enables clients to develop and modify programs conveniently by importing instructions in a non-coded manner.After experimental testing,the platform is proved successful achieving both the rapid development of PLC control system and the rapid modification of monitoring software. | 王兴 Tang Xianwei Dong Zengshou Zhen Liaomo | 2021 | High Technology Letters2021，27，2： | 3 |
| 3 | Wavelet packet based damage identification of beam structures 显示文摘 | Han Jiangang Ren Weixing Sun Zengshou | 2005 | International Journal of Solids and Structures2005，42，26： | 1 |
| 4 | Polyphenol control of nitrogen release from pine litter显示文摘 | Northup R R Zengshou Y Daligren R A | 1995 | Nature1995，377，： | 1 |
| 5 | Fault diagnosis for hydraulic system on a modified multi-sensor information fusion method显示文摘 | Dong Zengshou Zhang Xujing Zeng Jianchao | | 0，，01： | 1 |
| 6 | Wavelet packet based damage identification of beam structures 显示文摘 | Han Jian'gang Ren Weixin Sun Zengshou | 2005 | International Journal of Solids and Structures2005，42，6： | 1 |
| 7 | Structural damage identification by using wavelet entropy显示文摘 | Ren Weixin Sun Zengshou | 2008 | Engineering Structures2008，30，： | 1 |
| 8 | Seismic reliability analysis of pipeline system 显示文摘 | Chen Huai Li Jie Sun Zengshou | 1995 | Journal of Southern University1995，11，1： | 1 |
| 9 | Wavelet packet based damage identification of beam structures 显示文摘 | Han Jiangang Ren Weixin Sun Zengshou | 2005 | International Journal of Solids and Structures2005，42，26： | 1 |
| 10 | Polyphenol control of nitrogen release from pine litter 显示文摘 | Northup R Zengshou Y Daligren RA | 1995 | Nature1995，377，： | 1 |
| 11 | Wavelet packet based damage identification of beam structures 显示文摘 | Han Jiangang Ren Weixin Sun Zengshou | 2005 | International Journal of Solids and Structures2005，42，26： | 1 |
| 12 | Wavelet packet based damage identification of beam structures 显示文摘 | Han Jiangang Ren Weixin Sun Zengshou | 2005 | International Journal of Solids and Structures2005，42，26： | 1 |
| 13 | Reactivity of iodide in volcanic soils and noncrystalline soil constituents 显示文摘 | Yu Zengshou Warner J A Dahlgren R A Casey W H | 1996 | Geochim Cosmochim Aeta1996，60，24： | 1 |
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