|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A viral protein orchestrates rice ethylene signaling to coordinate viral infection and insect vector-mediated transmission显示文摘Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus that is frequently transmitted by planthoppers. However, the molecular mechanisms underlying its propagation in the host plants and epidemics in the field are largely unknown. Here, we showed that the SRBSDV-encoded P6 protein is a key effector that regulates rice ethylene signaling to coordinate viral infection and transmission. In early SRBSDV infection, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation;this also repels the insect vector to reduce infestation. In late infection, P6 enters the nucleus, where it interacts with OsEIL2, a key transcription factor of ethylene signaling. The P6-OsEIL2 interaction suppresses ethylene signaling by preventing the dimerization of OsEIL2, thereby facilitating viral transmission by attracting the insect vector. Collectively, these findings reveal a novel molecular mechanism by which an arbovirus modulates the host defense system to promote viral infection and transmission. | Yaling Zhao Xue Cao Weihua Zhong Shunkang Zhou Zhanbiao Li Hong An Xiahua Liu Ruifeng Wu Surakshya Bohora Yan Wu Zhenyi Liang Jiahao Chen Xin Yang Guohui Zhou Tong Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 2 | miR-100-5p in human umbilical cord mesenchymal stem cell-derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway显示文摘Exosomes derived from human umbilical cord mesenchymal stem cells(hUCMSC-Ex)play important roles in immune and inflammation diseases.However,the role of hUCMSC-Ex in atherosclerosis has not been elucidated.In this study,the isolated exosomes were identified by transmission electron microscopy and nanoparticle tracking analysis.Exosome marker protein levels were increased in the hUCMSC-Ex compared with those in hUCMSC suspension,indicating that exosomes were successfully isolated from hUCMSCs.Furthermore,eosinophils were treated with oxidized low-density lipoprotein(ox-LDL)to construct inflammation model and then incubated with hUCMSC-Ex derived from hUCMSCs which were transfected with miR-100-5p mimic or miR-100-5p inhibitor.We found that hUCMSC-Ex increased miR-100-5p expression,inhibited cell migration,promoted cell apoptosis,and reduced inflammatory cytokine levels in ox-LDL-treated eosinophils,and miR-100-5p overexpression in hUCMSCs enhanced these effects,while miR-100-5p inhibition reversed these effects.Moreover,frizzled 5(FZD5)was a target gene of miR-100-5p.FZD5 overexpression reversed the inhibitory effects of hUCMSC-Ex-miR-100-5p on cell progression and inflammation in eosinophils.Additionally,hUCMSC-Ex-miR-100-5p decreased the expression of cyclin D1 andβ-catenin proteins.Wnt/β-catenin pathway activator BML-284 effectively reversed the effects of hUCMSC-Ex-miR-100-5p on cell progression and inflammation in eosinophils.ApoE−/−mice were fed with high-fat diet to construct an atherosclerosis mice model,and hUCMSC-Ex was injected into mice.hUCMSC-Ex reduced atherosclerotic plaque area and inflammation response in atherosclerosis mice.This study demonstrates that hUCMSC-Ex-miR-100-5p inhibits cell progression and inflammatory response in eosinophils via the FZD5/Wnt/β-catenin pathway,thereby alleviating atherosclerosis progression. | Heng Gao Zhanbiao Yu Yuanyuan Li Xue Wang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 3 |
| 3 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 4 | Response inhibition in adolescent earthquake survivors with and without posttraumatic stress disorder: A combined behavioral and ERP study显示文摘 | Jianhui Wu Yan Ge Zhanbiao Shi Xiaoju Duan Li Wang Xianghong Sun Kan Zhang | 2010 | Neuroscience Letters2010，，3： | 1 |
| 5 | Psychometric properties of the 10-item Connor-Davidson resilience scale in Chinese earthquake victims显示文摘 | Wang Li Shi Zhanbiao Zhang Yuqing | 2010 | Psychiat Clin Neuros2010，64，5： | 1 |
| 6 | Ex- perimental Observations of Tyre Deformation Char- acteristics on Heavy Mining Vehicles under Static and Quasi-static Loading显示文摘 | Tonkovich A Li Zhanbiao DiCeceo S | 2012 | Journal of Terrame- chanics2012，49，34： | 1 |
| 7 | Regulation effects on abnormal glucose and lipid metabolism of TZQ-F, a new kind of Traditional Chinese Medicine显示文摘 | Wang Tao Zhang Deqin Li Yuhong Liu Hong Liu Zhanbiao Zhao Chunfeng Hu Limin Gao Xiumei | 2010 | Journal of Ethnopharmacology2010，，3： | 1 |
| 8 | Psychometric properties of the 10-item Connor-Davidson resilience scale in Chinese earthquake victims显示文摘 | Wang Li Shi Zhanbiao Zhang Yuqing | 2010 | Psychiat Clin Neuros2010，64，5： | 1 |
| 9 | Psychometric properlies of the 10-item Connor-Davidson Resilience Scale in Chinese earthquake victims显示文摘 | Wang Li Shi Zhanbiao Zhang Yuqing | 2010 | Psychiatry Clin Neurosci2010，6，5： | 1 |
| 10 | Mental health prob- lems among children one-year after Sichuan earthquake in China: a follow-up study显示文摘 | Liu Mingxin Wang Li Shi Zhanbiao | 2011 | PLoS One2011，6，14： | 1 |
| 11 | Research on the Motives of the Qualification Problem of Assets Valuation Industry in China——Study Based on Questionnaire and Factor Analysis显示文摘 | Zhanbiao Li Jun Bai | 2015 | International English Education Research2015，，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员