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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | The effect of comorbid illness and functional status on the expected benefits of intensive glucose control in older patients with type 2 diabetes: a decision analysis显示文摘 | Huang ES Zhang Q Gandra N | 2008 | Ann Intern Med2008，149，1： | 1 |
| 3 | The effect of comorbid illness and functional status on the expected benefits of intensive glucose con- trol in older patients with type 2 diabetes: a decision analysis 显示文摘 | Huang ES Zhang Q Gandra N | 2008 | Ann Intern Med2008，149，1： | 1 |
| 4 | Development and applica- tions of CRISPR-Cas9 for genome engineering 显示文摘 | Hsu PD Lander ES Zhang F | 2014 | Cell2014，157，6： | 1 |
| 5 | From human genetics and genomics to pharmacogenetics and pharmacogenomics:past lessons,future directions显示文摘 | Nebert DW Zhang G Vesell ES | | 0，，02： | 1 |
| 6 | Transgenic inhibition of glial NF - KB reduces pain behavior and iilflammation after peripheral nerve injury 显示文摘 | Fu ES Zhang YP Sagen J | 2010 | Pain2010，148，3： | 1 |
| 7 | Proteomic analysis of potential keratan sulfate,chondroitin sulfate A,and hyaluronic acid molecular interactions显示文摘 | Conrad AH Zhang Y Tasheva ES | | Invest Ophthalmol Vis Sci0，51，9： | 1 |
| 8 | Peroxisome proliferator-acti- vated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellatc cells in vitro显示文摘 | Yu J Zhang S Chu ES | 2010 | Int J Biochem Cell Biol2010，42，6： | 1 |
| 9 | 13 AR signaling required for diet induced thermogenesis and obesity resistance显示文摘 | Bachman ES Dhillon H Zhang CY | 2002 | Science2002，297，5582： | 1 |
| 10 | Channelrhodopsin-2 and optical control of excitable cells显示文摘 | Zhang F Wang LP Boyden ES | 2006 | Nat Methods2006，3，10： | 1 |
| 11 | Cell cycle control of centromeric repeat transcription and heterochromatin assembly 显示文摘 | CHEN ES ZHANG K NICOLAS E | 2008 | Nature2008，，451： | 1 |
| 12 | Peroxisome proliferatoractivated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cellsin vitro显示文摘 | Yu J Zhang S Chu ES | | 0，，6： | 1 |
| 13 | Development and applications of CRISPR-Cas9 for genome engineering 显示文摘 | Hsu PD Lander ES Zhang F | 2014 | Cell2014，157，6： | 1 |
| 14 | The FREP gene family in the snail Biomphalaria glabrata: additional members, and evidence consistent with alternative splicing and FREP retrosequences 显示文摘 | Zhang SM Loker ES | 2003 | Dev Comp Immunol2003，27，3： | 1 |
| 15 | Increased betal integrin is associated with decreased survival in invasive breast cancer 显示文摘 | Yao ES Zhang H Chen YY Lee B Chew K Moore D | 2007 | Cancer Res2007，67，2： | 1 |
| 16 | Disease-specific health status after stent-assisted percutaneous coronary intervention and coronary artery bypass surgery:one-year results from the stent or surgery trial显示文摘 | Zhang ZE Mmahoney ES Rodney H | 2003 | Circulation2003，108，14： | 1 |
| 17 | ADL dependence and medical conditions in Chinese older persons:a population-based survey in Shanghai,China显示文摘 | Chen P Yu ES Zhang M | 1995 | J Am Geriatr Soc1995，43，4： | 1 |
| 18 | Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes显示文摘 | Zhang H Pourdehnad M Lambright ES | 2001 | J Nucl Med2001，42，9： | 1 |
| 19 | Characterization of immune genes from the sehitosome host snail Biomphalaria glabrata that encode peptidoglycan recognition proteins and Gram- negative bacteria binding protein 显示文摘 | Zhang SM Zeng Y Loker ES | 2007 | Immunogenetics2007，59，11： | 1 |
| 20 | Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury显示文摘 | Fu ES Zhang Y P Sagen J | 2010 | Pain2010，148，3： | 1 |
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