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| 1 | Whether Syndrome Differentiation Affects Treatment Result:Study Protocol of MaZiRenWan(麻子仁丸)for Functional Constipation in A Randomized Controlled Trial显示文摘Background: Syndrome is one of the most important concepts in Chinese medicine(CM) theory. However, it was not well accounted in most of randomized controlled trials(RCTs). Objective: To determine whether CM syndrome differentiation affects the treatment results, functional constipation(FC) was selected as a target disease, and MaZiRenWan(麻子仁丸, MZRW), a classic CM formula commonly used for constipation with excessive heat syndrome, was selected for study. Methods: It is an 18-week prospective double-blinded, doubledummy RCT, including 2-week run-in, 8-week treatment and 8-week post treatment follow-up. A total of 120 FC patients diagnosed as excessive heat syndrome will be recruited from the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine. Patients will be randomly allocated into fixed MZRW(f_MZRW) granule group, modified MZRW(m_MZRW) granule group or bisacodyl group. For m_MZRW group, no more than two herbal granules can be added according to the syndrome differentiation for individual participants. The primary end point is the mean of complete spontaneous bowel movements(CSBMs) per week during the treatment period. Secondary end points include mean of CSBMs per week during follow-up, stool form, global symptom improvement, constipation and constipation-related symptoms assessment, CM syndrome change, and reported adverse events. Discussion: This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. | CHENG Chung-wah ZHANG Li ZHAO Chen ZHONG Linda LD SHI Li-jie DAI Liang ZHENG Rui CHEN Jing LI Ge ZHAI Jing-bo KUN Wai LU Ai-ping SHANG Hong-cai BIAN Zhao-xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 3 |
| 2 | Expression of hepatitis B vi- rus surface antigen determinants in Lactococcus lactis for oral vaccination显示文摘 | Zhang QX Zhong J Huan LD | 2011 | Microbiol Res2011，16，2： | 1 |
| 3 | Cisplatin resistance in an ovarian carcinoma is associated with a defect in programmed cell death control through XIAP regulation显示文摘 | Mansouri A Zhang Q Ridgway LD | 2003 | Oncol Res2003，13，610： | 1 |
| 4 | The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas显示文摘 | Batista LD Zhang X Gejman R | | 0，，11： | 1 |
| 5 | Dysfunc- tion of organic anion transporting polypeptide 1 al alters intesti- nal bacteria and bile acid metabolism in mice 显示文摘 | Zhang Y Limaye PB Lehman - McKeeman LD | 2012 | PLoS One2012，7，34： | 1 |
| 6 | The genetics of monarch butterfly migration and warning colouration显示文摘 | Zhan S Zhang W Niitepld K | 2014 | Nature2014，514，： | 1 |
| 7 | A new method for EST clustering 显示文摘 | Zhang LD Yuan DJ Zhang JW | 2003 | Yi Chuan Xue Bao2003，30，： | 1 |
| 8 | Nanosizing interme- tallic compounds onto carbon nanotubes: active and selective hydrogenation catalysts 显示文摘 | Shao LD Zhang W Armbruster M | 2011 | Angewandte Chemic International Edition2011，50，10： | 1 |
| 9 | Biological effects of a nano red elemental selenium 显示文摘 | Zhang JS Gao XY Zhang LD Bao YP | 2001 | Bio Factors2001，15，： | 1 |
| 10 | Loss of organic anion transporting polypeptide 1 al increases deoxycholic acid absorption in mice by increasing intestinal permeability 显示文摘 | Zhang Y Csanaky IL Lehman - McKeeman LD | 2011 | Toxicol Sci2011，124，2： | 1 |
| 11 | The dopaminergic system in hypertension显示文摘 | Zeng C Zhang M Asico LD | 2007 | Clin Sci2007，112，12： | 1 |
| 12 | Mechanisms of resistance to TRAIL - induced apopto- sis in cancer显示文摘 | Zhang LD Fang BL | 2005 | Cancer Gene Therapy2005，12，： | 1 |
| 13 | Increased expression of GRP94 protein is associated with decreased sensitivity to adriamycin in ovarian carcinoma cell lines 显示文摘 | Zhang LY Zang XC Wang LD | 2008 | Clin Exp Obstet Gynecol2008，35，4： | 1 |
| 14 | Arbuscular mycorrhizal fungi associated with common pteridophytes in Dujiangyan, southwest China显示文摘 | Zhang Y Guo LD Liu RJ | 2004 | Mycorrhiza2004，14，1： | 1 |
| 15 | Lung cancer and environmental tobacco smoke in a non-industrial area of China 显示文摘 | Wang LD Lubin JH Zhang SR | 2000 | Int J Cancer2000，88，1： | 1 |
| 16 | Slow release of molecules in self-assembling peptide nanofiber scaffold显示文摘 | Nagai Y Unsworth LD Koutsopoulos S Zhang S | 2006 | J Control Release2006，115，： | 1 |
| 17 | Survey of arbuscular mycorrhizal fungi in deforested and natural forest land in the subtropical region of Dujiangyan, southwest China显示文摘 | Zhang Y Guo LD Liu RJ | 2004 | Plant and Soil2004，261，12： | 1 |
| 18 | Association of angiotensinogengene M235T and angiotensin-converting enzyme gene I/D poly-morphisms with essential hypertension in Han Chinese popula-tion: a meta-analysis显示文摘 | Ji LD? Zhang LN Shen P | 2010 | J Hypertens2010，28，3： | 1 |
| 19 | Correlation between expression and significance of -catenin, CD31, and VEGF of non-small cell lung cancer 显示文摘 | Liu XL Liu LD Zhang SG | 2015 | Genet Mol Res2015，14，13： | 1 |
| 20 | A study of the internal friction and modulus of epoxy resin dispersed nanometer-sized alumina particles显示文摘 | Zhang LD Xie CY Zhu XF | 1994 | J Alloys Compounds1994，，： | 1 |
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