|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 2 | Geotechnical risk management to prevent coal outburst in room-and-pillar mining显示文摘A coal outburst is a severe safety hazard in room-and-pillar mining under deep cover. It is more likely to occur during pillar retreating. Multi-seam mining dramatically increases the risk of coal outburst within the influence zones created by remnant pillars and gob-solid boundaries. Though coal outburst is generally associated with heavy loading of coal pillars,its occurrence is difficult to predict. Risk management provides a proactive tool to minimize coal outburst in room-and-pillar mining under deep cover. Risk assessment is the first step in identifying and quantifying outburst risk factors. The primary risk factors for coal outburst are overburden depth,roof and floor strength,geological anomalies,mining type,multi-seam mining,and panel width. A risk assessment chart can be used to proactively screen out mining sections with high risk of coal outburst for further analysis. Gob-solid boundaries and remnant pillars are critical factors in evaluation of the coal outburst risk of multi-seam mining. Risk identification,risk assessment,geologic influence mapping,geotechnical evaluation,risk analysis,risk mitigation,and monitoring are essential elements of coal outburst risk management process. Training is an integral part of risk management for risk identification and communication between all the stakeholders including management,technical and safety personnel,and miners. | zhang peter peterson scott neilans dan wade scott mc grady ryan pugh joe | 2016 | International Journal of Mining Science and Technology2016，26，1： | 8 |
| 3 | Overexpression/amplification of HER-2/neu is uncommon in hepatocellular carcinoma显示文摘 | Xian ZH Zhang SH Cong WM Wu WQ Wu MC | 2005 | 第二军医大学学报2005，26，11： | 6 |
| 4 | Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma显示文摘 | Xian ZH Zhang SH Cong WM Yan HX Wang K Wu MC | 2006 | 第二军医大学学报2006，27，5： | 6 |
| 5 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 6 | TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses显示文摘 | Yu L Hebert MC Zhang YE | 2002 | EMBO J2002，21，14： | 2 |
| 7 | Mechanical tension and inte- grin alpha 2 beta 1 regulate fibroblast functions 显示文摘 | Eckes B Zweers MC Zhang ZG | 2006 | J Investig Der- matol Symp Proc2006，11，1： | 1 |
| 8 | High systnic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic prcgression of existing knee OA: the MOST study显示文摘 | Nevitt MC Zhang Y Javaid MK | 2010 | Ann Rheum Dis2010，69，1： | 1 |
| 9 | Mental Health and Social Support Among HW - Positive Injection Drug Users and Their Caregivers in China显示文摘 | Greene MC Zhang JP Li JP | 2013 | AIDS Behav2013，17，5： | 1 |
| 10 | Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma显示文摘 | Bao LJ Jaramillo MC Zhang ZB | 2014 | Int J Clin Exp Pathol2014，7，4： | 1 |
| 11 | Echinocosis显示文摘 | Mc Manus Zhang D P W Li J | 2005 | Lancet2005，362，： | 1 |
| 12 | Overexpressed PAK4 promotes proliferation, migration and invasion of ehoriocarcinoma 显示文摘 | Zhang HJ Siu MK Yeung MC | 2011 | Carcinogenesis2011，32，5： | 1 |
| 13 | Tamoxifen elicits rapid transmembrane lipid signal responses in human breast cancer cells 显示文摘 | Cabot MC Zhang ZC Giuliano AE | 1995 | Breast Cancer Res Treat1995，36，3： | 1 |
| 14 | The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammationin antigen-sensitized and antigen-challenged aged mice显示文摘 | Busse P J Schofield B Birmingham N Yang N Wen MC Zhang T Srivastava K Li XM | | 0，，03： | 1 |
| 15 | A review of the effectiveness of oral health promotion activities among elderly people显示文摘 | Mc Grath C Zhang W Lo EC | 2009 | Gerodontology2009，26，2： | 1 |
| 16 | The emerging role of the Nrf2-Keap1 signaling pathway in cancer显示文摘 | Jaramillo MC Zhang DD | 2013 | Genes Dev2013，27，20： | 1 |
| 17 | DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to meta- static tumor heterogeneity 显示文摘 | Yegnasubramanian S Haffner MC Zhang Y | 2008 | Cancer Res2008，68，21： | 1 |
| 18 | Langerhans cell histiocytosis of the orbit:five clinicopathologic cases and review of the literature显示文摘 | Herwig MC Wojno T Zhang Q | | 0，，： | 1 |
| 19 | Klotho is a phosphaturichormone:in vivo evidence显示文摘 | Hu MC Zhang J? Shi M | 2006 | J Am Sco Nephrol2006，17，： | 1 |
| 20 | Genomic organization of the human fibroblast growth factor receptor 2 ( FGFR2 ) gene and comparative analysis of the human FGFR gene family 显示文摘 | Zhang Y Gorry MC Post JC | 1999 | Gene1999，230，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员