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| 1 | Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B显示文摘AIM: To evaluate the clinical efficacy of salvianolic acidB (SA-B) on liver fibrosis in chronic hepatitis B.METHODS: Sixty patients with definite diagnosis of liverfibrosis with hepatitis B were included in the trial.Interferon-γ (IFN-γ) was used as control drug. Thepatients took orally SA-B tablets or received muscularinjection of IFN-γ in the double blind randomized test,The complete course lasted 6 months. The histologicalchanges of liver biopsy specimen before and after thetreatment were the main evidence in evaluation, incombination with the results of contents of serum HA,LN, Ⅳ-C, P-Ⅲ-P, liver ultrasound imaging, andsymptoms and signs.RESULTS: Reverse rate of fibrotic stage was 36.67 % inSA-B group and 30.0 % in IFN-γgroup. Inflammatoryalleviating rate was 40.0 % in SA-B group and 36.67 %in IFN-γ group. The average content of HA and Ⅳ-Cwas significantly lower than that before treatment. Theabnormal rate also decreased remarkably. Overallanalysis of 4 serological fibrotic markers showedsignificant improvement in SA-B group as comparedwith the IFN-γgroup. Score of liver ultrasound imagingwas lower in SA-B group than in IFN-γgroup (HA 36.7 %vs80 %,Ⅳ-C 3.3 % vs23.2 %). Before the treatment,ALT AST activity and total bilirubin content of patientswho had regression of fibrosis after oral administrationof SA-B, were significantly lower than those of patientswho had aggravation of fibrosis after oraladministration of SA-B. IFN-γ showed certain sideeffects (fever and transient decrease of leukocytes,occurrence rates were 50 % and 3.23 %), but SA-Bshowed no side effects.CONCLUSION: SA-B could effectively reverse liverfibrosis in chronic hepatitis B. SA-B was better than IFN-γ in reduction of serum HA content, overall decrease of4 serum fibrotic markers, and decrease of ultrasoundimaging score. Liver fibrosis in chronic hepatitis B withslight liver injury was more suitable to SA-B in anti-fibrotic treatment. SA-B showed no obvious side effects. | Ping Liu Yi-Yang Hu Cheng Liu Hui-Ming Xue Zhi-Qiang Xu Lie-Ming Xu Cheng-Hai Liu Hong-Tu Gu Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China Da-Yuan Zhu Shanghai Institute of Metaria Medica,Chinese Academy of Sciences,Shanghai 200031,China Zhi-Qing Zhang the 4~(th) Hualyin City Hospital,Hualan City,223000,JiangSu Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 85 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment显示文摘Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor regions.In recent years,large-scale genomic studies and new next-generation sequencing technologies have uncovered more scientifc details about tumor heterogeneity,with significant implications for the choice of specific molecular biomarkers and clinical decision making Genomic heterogeneity signifcantly contributes to the generation of a diverse cell population during tumor development and progression,representing a determining factor for variation in tumor treatment response.It has been considered a prominent contributor to therapeutic failure,and increases the likelihood of resistance to future therapies in most common cancers.The understanding of molecular heterogeneity in cancer is a fundamental component of precision oncology,enabling the identification of genomic alteration of key genes and pathways that can be targeted therapeutically.Here,we review the emerging knowledge of tumor genomics and heterogeneity,as well as potential implications for precision medicine in cancer treatment and new therapeutic discoveries.An analysis and interpretation of the TCGA database was included. | Jialing Zhang Stephan Stanislaw Späth Sadie L.Marjani Wengeng Zhang Xinghua Pan | 2018 | Precision Clinical Medicine2018，1，1： | 5 |
| 4 | Preface to Special Issue of Chinese Journal of Catalysis on the 2nd International Congress on Catalysis for Biorefineries (CatBior 2013)显示文摘 | Tao Zhang Avelino Corma Ferdi Schüth | 2014 | 催化学报2014，35，5： | 5 |
| 5 | Presence and integration of HBV-DNA in mouse oocytes显示文摘 | Huang TH Zhang QJ Xie QD | 2005 | World J Gastroenterol2005，11，： | 1 |
| 6 | Monitoring constancy of variance in conditionally heteroskedastic time series显示文摘 | Horváth L Kokoszka P Zhang A | 2006 | Econometric Theory2006，22，： | 1 |
| 7 | Preparation and pharmacokinetic characterization of sustained release melatonin tablet显示文摘 | HE ZG ZHANG TH TANG X | 2003 | J Chin Pharm Sci2003，12，2： | 1 |
| 8 | Directed evolution for engineering pH profile of endoglucanase III from Trichoderma reesei 显示文摘 | Wang T Liu XM Yu Q Zhang X Qu YB Gao P J Wang TH | 2005 | Biomolecular Engineering2005，22，13： | 1 |
| 9 | Exact solutions for one-dimensional transport with asymptotic scale-dependent dispersion显示文摘 | Huang K van Genuchten M Th Zhang R | 1996 | Applied Mathematical Modelling1996，20，4： | 1 |
| 10 | Effects of dlp raerup torin a on interleukin -6 level and Fas,Bax,Bcl-2 protein expression in ischemia reperfusion myocardium显示文摘 | Chang TH Liu XY Zhang XH | 2002 | Acta Pharmacol Sin2002，23，9： | 1 |
| 11 | The per- formance of human dental pulp stem cells on different three-di- mensional scaffold materials 显示文摘 | Zhang W Walboomers XF van Kuppevelt TH | 2006 | Biomat2006，27，33： | 1 |
| 12 | Hemoglobin H disease in Guangxi province,Southern China:clinical review of 357 patients显示文摘 | Yin XL Zhang Xh Zhou TH | | 0，，02： | 1 |
| 13 | Generation of marker-free transgenic maize by regular two border Agrobacterium transformation vectors显示文摘 | Huang S Gilbertson LA Adams TH Malloy KP Reisenbigler EK Birr DH Snyder MW Zhang Q Luethry MH | | 0，，： | 1 |
| 14 | Urokinase-type plasminogen activator stimulation of monocyte matrix metalloproteinase-1 production is mediated by plasmin-dependent signaling through annexin A2 and inhibited by inactive plasmin显示文摘 | Zhang Y Zhou ZH Bugge TH | | 0，，05： | 1 |
| 15 | The Chinese government's response to drug use and HIV/AIDS:a review of policies and programs显示文摘 | Li J Ha TH Zhang C | 2010 | Harm Reduct J2010，5，7： | 1 |
| 16 | Prodromal psychosis de-tection in a counseling center population in China:An epidemio-logical and clinical study显示文摘 | Zhang TH Li HJ Woodberry KA | 2014 | Schizophr Res2014，152，2： | 1 |
| 17 | Microarray analysis of gene expression in MEN1 knockout embryoid body reveals genetic events involved in early mouse embryonic development 显示文摘 | Zhang HL Luo TH Feng L | 2007 | Biochem Biophys Res Commun2007，352，2： | 1 |
| 18 | Effective inhibition of HC-MV UL49 gene expression and viral replication by externalguide sequences and RNase P 显示文摘 | Zhang WJ Li HJ Zhou TH | 2010 | Virology J2010，7，： | 1 |
| 19 | Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model显示文摘 | Zhang L Jia TH Chong AC | 2010 | 17(10):1262-12692010，17，10： | 1 |
| 20 | Symptomatic and asymptomatic infections of rotavirus, norovirus, and adenovirus among hospitalized children in Xilm, China 显示文摘 | Zhang S Chen TH Wang J | 2011 | J Med Virol2011，83，8： | 1 |
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