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| 1 | A New Capillary Electrophoresis Apparatus with Piezoelectric Ceramics High Voltage Source and Amperometric Detector显示文摘IntroductionHighperformancecapiliar}'electrophoresis(HPCE)isanewanalyticaltechnology'rapidly'developedinrecentyears.Withtheadvantagesofsmallsample.highsensitivity,highresolution.rapidanalysisandverycheaprunning,ithasbeenappliedinchemistry'.lifescienc... | Chen, ZG Mo, JYM Yang, XY Wang, LS Mei, XT Zhang, MS | 1999 | Chinese Chemical Letters1999，10，3： | 19 |
| 2 | Over-expression of heat shock protein 27 attenuates doxorubicin-induced cardiac dysfunction in mice显示文摘 | Liu,L Zhang,X Qian,B Min,XY Gao,X Li,CF Cheng,YL Huang,J | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 15 |
| 3 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 4 | Quality control measures for lowering the seroconversion rate of hemodialysis patients with hepatitis B or C virus显示文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population. | Jing Yuan,Yi Yang, Fei Han, Ping Zhang, Xiao-Ying Du, Hua Jiang and Jiang-Hua Chen The Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of Medicine (Yuan J, Yang Y, Han F, Zhang P, Du XY, Jiang H and Chen JH) and Hemodialysis Quality Control Center of Zhejiang Province (Yuan J, Zhang P, Du XY and Chen JH), Hangzhou 310003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 2 |
| 5 | THE SOLVABILITY CONDITIONS FOR THE INVERSE PROBLEM OF MATRICES POSITIVE SEMIDEFINITE ON A SUBSPACE显示文摘This paper studies the following two problems:Problem Ⅰ. Given X, B ∈ Rnxm, find A ∈ Ps,n, such that AX = B, where Ps, n = {A ∈ SRnxn|XTA>0,STX = 0, for given S ∈ R}.Problem Ⅱ. Given A* ∈ Rnxn, find A ∈ SE, such that ||A*-A|| = infA∈SE||A* -A|| where SE denotes the solution set of Problem Ⅰ.The necessary and sufficient conditions for the solvability of Problem Ⅰ, the expression of the general solution of Problem Ⅰ and the solution of Problem Ⅱ are given for two cases. For the general case, the equivalent form of conditions for the solvability of Problem Ⅰ is given. | HU, XY ZHANG, L DU, WZ | 1994 | Journal of Computational Mathematics1994，12，1： | 2 |
| 6 | Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus显示文摘 | Zhang GY Zong YY | 2003 | Neurosci Lett2003，343，2： | 1 |
| 7 | Effects of platelet-activating factor,tumor necrosis factor,and interleukin-1α on the expression of apolipoprotein M in HepG2 cells显示文摘 | Xu N Zhang XY Dong X | 2002 | Biochem Biophys Res Commun2002，292，4： | 1 |
| 8 | Trends in prevalence of HIV, syphilis, hepatitis C, hepatitis B and sexual risk behav- ior among men who have sex with ruen 显示文摘 | Ma XY Zhang QY He X | 2007 | J Acquit Immune Defic Syndr2007，45，5： | 1 |
| 9 | L-type voltage-gated Ca^2+ channel attends regulation of tyrosine phosphorylation of NMDA receptor subunit 2A induced by transient brain ischemia显示文摘 | Liu Y Hou XY Zhang GY | 2003 | Brain Res2003，972，： | 1 |
| 10 | Transforming growth factor-beta down-regulates apolipoprotein M in HepG2 cells显示文摘 | Xu N Hurtig M Zhang XY Ye Q Nilsson-Ehle P | 2004 | Biochim Biophys Acta2004，1683，13： | 1 |
| 11 | Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation显示文摘 | Yang HL Jiang XC Zhang XY | 2006 | BMC Infect Dis2006，6，： | 1 |
| 12 | Clinical efficacy of a308 nm excimer laser in the treatment of vitiligo显示文摘 | ZHANG XY HE YL DONG J et a1 | 2010 | Photoder-matol Photoimmunol Photomed2010，26，3： | 1 |
| 13 | Suicide rates in China,1995-1999显示文摘 | Michael RP Li XY Zhang YP | | 0，，： | 1 |
| 14 | Optimization of high-speed counter-current chromatography for separation of polyphenols from the extract of hawthorn (Crataegus laevigata) with response surface methodology显示文摘 | CUI HY JIA XY ZHANG X | 2011 | Separation and Purification Technology2011，77，2： | 1 |
| 15 | Liver abscesses in adult patients with and without diabetes mellitus: an analysis of the clinical character- istics, features of the causative pathogens, outcomes and predictors of fatality: a report based on a large population, retrospective study in China 显示文摘 | Tian LT Yao K Zhang XY | 2012 | Clin Microbiol Infect2012，18，9： | 1 |
| 16 | Phosphate ion targeted colorimetrie and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell 显示文摘 | Goo LE Zhang JF Liu XY | 2015 | Analytical Chemistry2015，87，： | 1 |
| 17 | Distinct role of tumor necrosis factor receptor subtypes 1 and 2 in the red nucleus in the development of neuropathic pain显示文摘 | Zeng XY Zhang Q Wang J | 2014 | Neurosci Lett2014，569，： | 1 |
| 18 | Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 ceils against cytotoxicity induced by hydrogen peroxide and tertbutyl hydroperoxide显示文摘 | Liu ZY Tao XY Zhang CW | 2005 | Biomed & Pharmacother2005，59，9： | 1 |
| 19 | The effect of soil flooding on the transformation of Fe - oxides and the adsorption/desorptian behavior of phosphate显示文摘 | Zhang YS Lin XY Werner W | 2003 | Journal of Plant Nutrition and Soil Science2003，166，： | 1 |
| 20 | Examination of POU homeobox gene expression in human breast cancer cells显示文摘 | Branch DR Zhang XY | 1999 | Int J Cancer1999，81，： | 1 |
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