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| 1 | Effect of Bcl-2 and caspase-3 on calcium distribution in apoptosis of HL-60 cells显示文摘Apoptosis manifests in two major execution programs downstream of the death signal: the caspase pathway and organelle dysfunction. An important antiapoptosis factor, Bcl-2 protein, contributes in caspase pathway of apoptosis. Calcium, an important intracellular signal element in cells, is also observed to have changes during apoptosis, which maybe affected by Bcl-2 protein. We have previously reported that in Harringtonine (HT) induced apoptosis of HL-60 cells, there’s a change of intracellular calcium distribution, moving from cytoplast especially Golgi’s apparatus to nucleus and accumulating there with the highest concentration. We report here that caspase-3 becomes activated in HT-induced apoptosis of HL-60 cells, which can be inhibited by overexpression of Bcl-2 protein. No sign of apoptosis or intracellular calcium movement from Golgi’s apparatus to nucleus in HL-60 cells overexpressing Bcl-2 or treated with Ac-DEVD-CHO, a specific inhibitor of caspase-3. The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi’s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase3. Calcium relocalization in apoptosis seems to be irreversible, which is different from the intracellular calcium changes caused by growth factor. | ZHANGMIN HONGQINGZHANG 等 | 2000 | Cell Research2000，10，3： | 19 |
| 2 | Comparison of the defluoridation efficiency of calcium phosphate and chitin in the exoskeleton of Antarctic krill显示文摘Calcium(Ca),phosphorus(P),and chitin are the main components of the exoskeleton of krill.Defluoridation of a solution of sodium fluoride(NaF) using calcium phosphate(Ca3(PO4)2) and chitin as defluoridation agents was studied.Orthogonal experiments were designed to find the optimum reaction conditions for defluoridation,to obtain the maximum defluoridation efficiency and fluoride removal capacity of calcium phosphate and chitin.At the same time,a comparison of the capacity of the two defluoridation agents was made.The results suggest that calcium phosphate has a far greater capability than chitin for the removal of fluoride(F) from water under similar reaction conditions.It is also suggested that Antarctic krill is likely to adsorb fluoride via compounds such as calcium phosphate,hydroxyapatite,and other compounds of Ca and P with the general form(Ca,X) x(PO4,HPO4,Y) y(OH,Z) z,in addition to chitin. | WANG Zhangmin YIN Xuebin | 2012 | Advances in Polar Science2012，23，3： | 3 |
| 3 | Characterization of [bmim]Cl/FeCl_3 Ionic Liquid with Spectra显示文摘bmim]Cl/FeCl3 ionic liquids (where bmim = 1-butyl-3-methylimidazolium) were characterized by XPS (X-ray photoelectron spectroscopy), FT-IR (Fourier transform infrared spectroscopy), Raman and NMR (nuclear magnetic resonance) spectra. The results show that Fe2Cl7 and FeCl4 ions are the principal anions in acidic ionic liquids, - - whose concentrations change with the content of FeCl3 and an equilibrium exists between them. An isosbestic point existing in FT-IR spectra indicates that an interaction involving at least two species occurs and their concentrations vary with acidity. Chemical shifts of the hydrogen located in the cations of ionic liquids are sensitive to the composition of ionic liquids. The change in chemical shifts may be explained in terms of anion-cation interactions. The chemical shifts of 2-H are affected by metal halides, which shift downfield and the 2-H is more deshielded with the increase in metal halides. | SunXuewen ZhaoSuoqi ZhangMin | 2005 | Petroleum Science2005，2，1： | 2 |
| 4 | 显示文摘 | ZhangMin(张敏) DingMingliang(丁明亮) ZhangTing(张婷) YangJinming(杨金明) | 2010 | 高等学校化学学报2010，31，： | 2 |
| 5 | 显示文摘 | ZhangMin(张敏) HuiYuanyuan(惠媛媛) ZhangRuolin(张若琳) QiuJianhui(邱建辉) | 2012 | 塑料2012，41，： | 2 |
| 6 | Age and Some Genetic Characteristics of Vertisols in China显示文摘The ages of organic matter of some dark-colored horizons and calcareous concretions in some Vertisols from tropical,subtropical and warm-temperate zones of China were studied using radiocarbon dating method.The relationship between soil age and genesis of Vertisols was also expounded based on the study of their genetic characteristics and micromorphological features.The results show that although Vertisols have developed for a relatively long time,their weathering and soil forming process are weak and young with little horizonation.This is closely related to their special grochemical soil forming environment.Low-lying terrain,heavy texture,clay minerals dominated by montmorillonites and alternative drying-wetting climate give rise to the vertic features expressed in intense swelling-shrinking and cracking-closing in soils.As a result,the soil development and soil leaching process are resisted,and the climatic effect on the horizonation is impeded.Moreover,pedoturbation eliminates the horizonation in the upper part of soil profile,and postpones their evolution into zonal soils.So vertisols show certain pedogenic inertia and stay at relatively young developmental stage.Therefore,Vertisols are intrazonal soils dominated by local soil forming factors such as the relief and parent materials. | ZHANGMIN LIULIANG-WU 等 | 1993 | Pedosphere1993，3，1： | 2 |
| 7 | Evaluation of the toxicity of fluorine in Antarctic krill on soft tissues of Wistar rats显示文摘Antarctic krill are a potential food source for humans and animals, but krill are known to contain high levels of fluorine (F). In this study, we investigated the toxicity of F in Antarctic krill using Wistar rats. There were three experimental groups: The control group were fed a basal diet, the krill treatment group were fed the same basal diet mixed with krill powder (150 mg·kg-1 F), and the sodium fluoride (NaF) treatment group were fed the basal diet with added NaF (150 mg·kg-1 F). General toxicity indicators including body weight and food intake were measured during the experiment. After three months the rats were dissected and tissue samples were collected from the liver, kidney, spleen, brain, and testis. Morphological changes in the cells of these tissues were assessed using HE staining. There were no significant differences in the body weight, the food intake, or the viscera coefficients among the three groups. In both treatment groups some pathological changes were observed in all soft tissue samples except the testis, although there were fewer and less severe pathological changes in the krill treatment group than in the NaF treatment group. The results showed that the toxicity of F in Antarctic krill was lower than for an equivalent amount of F in NaF, but it was still toxic to rats consuming large quantities of krill. The findings of this study highlight the need for further investigation into potential F toxicity if krill is to be used for human consumption. | ZHANG Ling LU Xiaoqi WANG Zhangmin QIN Liqiang YUAN Linxi YIN Xuebin | 2013 | Advances in Polar Science2013，24，2： | 2 |
| 8 | Coated controlled release fertilizer re-search and industrialization developmenta[J]显示文摘 | ZHANGMin(张民) YANGYuechao(杨越超) LAIFu-peng(来付朋) etal | 2005 | 化肥工业2005，32，5： | 1 |
| 9 | 显示文摘 | GUOYing-na(郭英娜) JIANGZhuo-song(姜茁松) ZHANGMin(张敏) FENGLi-juan(冯丽娟) ZHAOJin-ying(赵进英) LIJin-ehang(李金昶) | 2005 | 分析化学2005，33，： | 1 |
| 10 | Identification and quantitation of glycosidically bound aroma compounds in three tobacco types by gas chromatography - mass spectrometry 显示文摘 | Kai C Zhangmin X Wenjie P | 2013 | J Chromatography A2013，11，： | 1 |
| 11 | Thephysiologicaleffectsofnitrogenonfruittrees[J]显示文摘 | LIWenqing(李文庆) ZHANGMin(张民) SHUHuairui(束怀瑞) | | JournalofShandongAgriculturalUniversi-ty0，，： | 1 |
| 12 | 显示文摘 | HEHong-Yun(何红运) ZHANGMin(张敏) GAOBing-Ying(高丙莹) etal | 2012 | 无机化学学报2012，，： | 1 |
| 13 | 显示文摘 | LIBao-IK李保利) ZHANGMin(张敏)JIANGPing(姜萍) DONGXiang-chao(董襄朝) | | 化学学报0，，： | 1 |
| 14 | Antioxidant properties of tartary buckwheat wheat extracts as affected by different thermal processing methods 显示文摘 | ZhangMin Chen Haixia Li Jinlei | 2010 | Food Science and Technology2010，43，1： | 1 |
| 15 | PreparationandinvitroreleasepropertiesoflovastatinGpolylacticacidmicrospheres 显示文摘 | ZhangMin ZhangLiye | 2011 | JournalofBeijing UniversityofChemicalTechnology(NaturalScience)2011，38，2： | 1 |
| 16 | 显示文摘 | ZHuHao-han QINHal-kun ZHANGMin etal(朱浩瀚 秦海琨 张敏 等) | 2008 | 中国激光2008，35，6： | 1 |
| 17 | Surface Modification of UHMWPE for Use in Total Joint Rep lacements显示文摘 | ZhangMin James Susan P King Richard | 2004 | Biomedical Sciences Instrumentation2004，，40： | 1 |
| 18 | 显示文摘 | ZhangMin(张敏) LiRugang(李如钢) ZhangRongjun(张荣军) | 2010 | 材料导报2010，24，16： | 1 |
| 19 | The Develop- ment and Commercialization of Biobased显示文摘 | Yunxuan Weng Yingxin Zhou Zhangmin | 2014 | Biodegradable Plastics in China Industrial Biotechnology2014，10，2： | 1 |
| 20 | Evaluation of the biological toxicity of fluorine in Antarctic krill显示文摘Antarctic krill is a potentially nutritious food source for humans, but fluorine(F) toxicity is a matter of concern. To evaluate the toxicity of F in Antarctic krill, 30 Wistar rats were divided into three groups with different dietary regimens: a control group, a krill treatment group(150 mg·kg-1 F), and a sodium fluoride(NaF) treatment group(150 mg·kg-1 F). After three months, F concentrations in feces, plasma, and bone were determined, and the degree of dental and skeletal fluorosis was assessed. The F concentrations in plasma and bone from the krill treatment group were 0.167 0±0.020 4 mg.L-1 and 2 709.8±301.9 mg·kg-1, respectively, compared with 0.043 8±0.005 5 mg·L-1 and 442.4±60.7 mg·kg-1, respectively, in samples from the control group. Concentrations of F in plasma and bone in the krill treatment group were higher than in the control group, but lower than in the NaF treatment group. The degree of dental fluorosis in the krill treatment group was moderate, compared with severe in the NaF treatment group and normal in the control group. The degree of skeletal fluorosis did not change significantly in any group. These results showed that the toxicity of F in Antarctic krill was lower than for an equivalent concentration of F in NaF, but it was toxic for rats consuming krill in large quantities. To conclude, we discuss possible reasons for the reduced toxicity of F in Antarctic krill. The present study provides a direct toxicological reference for the consideration of Antarctic krill for human consumption. | ZHANG Ling LU Xiaoqi WANG Zhangmin QIN Liqiang LIN Zhiqin YUAN Linxi ZHANG Wen YIN Xuebin | 2014 | Advances in Polar Science2014，25，1： | 1 |
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