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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia显示文摘 | Liu X Fan XL Zhao Y Luo GR Li XP Li R Le WD | 2006 | 中国生物学文摘2006，20，10： | 2 |
| 3 | Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells显示文摘 | Long XH Zhao ZQ He XP | 2007 | Int J Mol Med2007，19，4： | 1 |
| 4 | Establishment of GC - MS fingerprint of fresh Houttuynia cordata 显示文摘 | Meng J Dong XP Zhao ZZ | 2005 | Chem Pharm Bull2005，53，11： | 1 |
| 5 | Toxic effects of over-load copper chloride on primary cultured rat asrocytes显示文摘 | Hu HL Wang XP Zhao YL | 2012 | Parkinsonism Relat Disord2012，18，： | 1 |
| 6 | Treatment of odontogenic Keratocysts: A fillow-uo 255 chinese patient显示文摘 | Zhao YF Wei JX Wang XP | 2002 | Oral surg Oral Medoral pathol Oral Radial Endod2002，94，2： | 1 |
| 7 | Establishment of HPLC - DAD - MS finger- print of fresh Houttuynia cordata 显示文摘 | Meng J Dong XP Zhao ZZ | 2005 | Chem Pharm Bull2005，53，12： | 1 |
| 8 | Simultaneous determination of andrographolide and dehydroandrographolide in Andrographis paniculata and Chinese medicinal by mieroemulsion electrokinetic chromatography显示文摘 | Zhao YF Luo XP Zhai ZD | 2006 | J Pharm Biome Ana2006，，40： | 1 |
| 9 | Parametric design and application of steering characteristic curve in control for electric power steering显示文摘 | XP Zhao X Li J Chen | 2009 | Mechatronics2009，，19： | 1 |
| 10 | Effects of calcitonin injected into various brain areas on pain threshold and Ca^2+ in rats 显示文摘 | Zhao XP Wang S Xia YH | 1996 | Zhongguo Yao Li Xue Bao1996，17，： | 1 |
| 11 | Non-invasive detection of endothelial dysfunction in patients with essential hypertension 显示文摘 | Li J Zhao SP Li XP | 1997 | Int J Cardiol1997，61，2： | 1 |
| 12 | Manganese chloride- induced G0/G1 and S phase arrest in A549 cells 显示文摘 | Zhao P Zhong WJ Ying XP | 2008 | Toxicology2008，250，1： | 1 |
| 13 | Primary hepatocytes of Tu-paia belangeri as a potential model for hepatitis C virus infection显示文摘 | Zhao XP Tang ZY Bettina K | 2002 | Clin Invest2002，109，： | 1 |
| 14 | Tissue factor pathway inhibitor-2 is downregulated by ox-LDL and inhibitsox- LDL induced vascular smooth muscle ceils proliferation and migration 显示文摘 | Zhao BL Luo XP Shi HM | 2011 | Thromb Res2011，128，2： | 1 |
| 15 | Non-invasive detection of en- dothelial dysfunction in patients with essential hyperten- sion显示文摘 | Li J Zhao SP Li XP | 1997 | Int J Cardiol1997，61，2： | 1 |
| 16 | Primary hepatocytes of Tupaia belangri as a potential model for hePatitis C virus infeetion 显示文摘 | Zhao XP Tang ZY Klumpp B | 2002 | J Clin Invest2002，109，2： | 1 |
| 17 | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin显示文摘 | Liou A P Lu XP Sei Y Zhao XL Pechhold S Carrero R J Raybould H E Wank S | | 0，，03： | 1 |
| 18 | The association of low plasma testosterone level with coronary artery disease in Chinese men显示文摘 | ZHAO X P LI XP WANG Z L | 1998 | Int J Cardiol1998，63，2： | 1 |
| 19 | Enterovirus 71 inhibits cellular type I interferon signaling by downregulating JAK1 protein expression 显示文摘 | Liu Y Zhang Z Zhao XH Yu R Zhang XP Wu SP Liu J Chi XY Song XH Fu L Yu YQ Hou LH Chen W | 2014 | Viral Immunol2014，27，6： | 1 |
| 20 | The association of low plasma testosterone level with coronary artery disease in Chinese men显示文摘 | Zhao SP Li XP | 1998 | Int J Cardiol1998，63，2： | 1 |
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