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| 1 | Biofilm Microenvironment-Responsive Nanotheranostics for Dual-Mode Imaging and Hypoxia-Relief-Enhanced Photodynamic Therapy of Bacterial Infections显示文摘The formation of bacterial biofilms closely associates with infectious diseases.Until now,precise diagnosis and effective treatment of bacterial biofilm infections are still in great need.Herein,a novel multifunctional theranostic nanoplatform based on MnO_(2)nanosheets(MnO_(2)NSs)has been designed to achieve pH-responsive dual-mode imaging and hypoxia-relief-enhanced antimicrobial photodynamic therapy(aPDT)of bacterial biofilm infections.In this study,MnO_(2)NSs were modified with bovine serum albumin(BSA)and polyethylene glycol(PEG)and then loaded with chlorin e_(6)(Ce_(6))as photosensitizer to form MnO_(2)-BSA/PEG-Ce_(6)nanosheets(MBP-Ce_(6)NSs).After being delivered into the bacterial biofilm-infected tissues,the MBP-Ce_(6)NSs could be decomposed in acidic biofilm microenvironment and release Ce_(6)with Mn^(2+),which subsequently activate both fluorescence(FL)and magnetic resonance(MR)signals for effective dual-mode FL/MR imaging of bacterial biofilm infections.Meanwhile,MnO_(2)could catalyze the decomposing of H2O_(2)in biofilm-infected tissues into O_(2)and relieve the hypoxic condition of biofilm,which significantly enhances the efficacy of aPDT.An in vitro study showed that MBP-Ce_(6)NSs could significantly reduce the number of methicillin-resistant Staphylococcus aureus(MRSA)in biofilms after 635nm laser irradiation.Guided by FL/MR imaging,MRSA biofilm-infected mice can be efficiently treated by MBP-Ce_(6)NSs-based aPDT.Overall,MBP-Ce_(6)NSs not only possess biofilm microenvironment-responsive dual-mode FL/MR imaging ability but also have significantly enhanced aPDT efficacy by relieving the hypoxia habitat of biofilm,which provides a promising theranostic nanoplatform for bacterial biofilm infections. | Weijun Xiu Siyu Gan Qirui Wen Qiu Qiu Sulai Dai Heng Dong Qiang Li Lihui Yuwen Lixing Weng Zhaogang Teng Yongbin Mou Lianhui Wang | 2020 | Research2020，，1： | 7 |
| 2 | Late Cenozoic Stratigraphy and Paleomagnetic Chronology of the Zanda Basin,Tibet, and Records of the Uplift of the Qinghai-Tibet Plateau显示文摘摘要:特征近来新生代构造 Qinghai 西藏高原的南部的边缘高举可以在 Zanda 盆从 fluvio 湖的阶层被推断, Ngari,西藏。在盆的厚fluvio湖的阶层是老的 5.890.78 妈并且他们的免职为 5.11 妈坚持了的 Magnetostratigraphic 学习表演,即在结束开始在早更新世的结束中新世、结束,在比 1.58 妈没有迟了的区域以第四级的冰川的阶段开始。沉积环境的分析显示高原开始了的南部的 Qinghai 西藏上的 Zanda 盆在 5.89 妈,高举比北 Qinghai 西藏高原迟了。在 Guge 和 Qangz | MENG Xiangang ZHU Dagang SHAO Zhaogang YANG Chaobin HAN Jianen YU Jia MENG Qingwei LU Rongping | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 6 |
| 3 | Determination of cell volume during equilibrium freezing process显示文摘A new type electronic particle counter (EPC, MultisizerTM 3, Beckman Coulter Inc., USA) was used to determine the volumes of human red blood cells (RBCs) in NaCl solutions of different osmolalities. The thermodynamics model describing cell response during freezing process was used to simulate the volume change of RBC in 0.9% NaCl solution during equilibrium freezing process. It was assumed that the effect of temperature on cell volume can be neglected compared to that of osmolality, then by using the phase diagram for the binary system sodium chloride/water, the osmolalities of the NaCl solution under different sub-zero temperatures can be obtained (converted from mass concentration), then the calculated values of RBC volumes can be validated by the experiments. | ZHAOGang HELiqun WANGPeitao DINGWeiping XIEXiaojian LIUZhong ZHANGHaifeng SHUZhiquan LUODawei GAODayong | 2003 | Chinese Science Bulletin2003，48，15： | 4 |
| 4 | Fiber Optic 3-Component Seismometer显示文摘所有金属 3 部件光纤维测震表被建议并且试验性地示威了。理论分析基于机电的理论被给。刻度结果证明轴敏感是大约 41 dB (re:0 dB=1 rad/g ) | Jing HAN Wentao ZHANG Dongshan JIANG Zhaogang WANG Fang LI | 2014 | Photonic Sensors2014，4，2： | 4 |
| 5 | A novel theoretical model for mass transfer of hollow fiber hemodialyzers显示文摘A novel theoretical model for mass transfer of hollow fiber bundles in hemodialyzers is presented. In the model, a hemodialyzer is considered as a porous zone which is composed of two non-interpenetrating porous flow zones. Firstly, the dialysate side (shell side) is thought as a porous medium zone. Then by solidifying the dialysate flow zone and the occupied zone by hollow fiber membrane, the rest zone of hemodialyzer (i.e. blood side or lumen side) is con-sidered as a porous medium zone too. Finally, the interface of the two flow zones is the fiber membrane through which mass transfer is performed. The dialysate and blood flows are all described by Navier-Stokes equations with Darcy momentum source terms. Kedem-Katchalsky equations as other source terms are added into Navier-Stokes equations to simulate the permeating flux through the membrane. All equations must be coupled together in the process of com-puting. The model is validated by the experimental data in literature. The simulative results show that the predicted clearances agree well with the experimental data, and the model in this paper is better than other models for the fore-cast of clearance. | DINGWeiping HELiqun ZHAOGang SHUZhiquan CHENGShuxia GAODayong | 2003 | Chinese Science Bulletin2003，48，21： | 4 |
| 6 | Upwelling Process of the Western Himalaya Mountains:Height and Velocity Estimation Evidenced by Formation and Evolution of the Zanda Basin,Tibet,China显示文摘把地质的调查, stratigraphic 节测量和室内的全面调查基于地, Zanda 盆在 Himalaya 板中的构造地点被查明,并且 Zanda 盆的形成和进化作为六个阶段在到早更新世的上新世期间被分类:(a) 主要指责裂缝的舞台,(b) 快指责裂缝的舞台,(c) 集中的指责裂缝的舞台,(d) 壅滞舞台,(e) 第二等的指责裂缝的舞台,和(f) 第二等的快指责裂缝的舞台。基于 Zanda 盆的这个六阶段的形成进化理论,当下列五上演,到早更新世的从上新世的西方的 Himalaya 山的 upwelling 过程被分类:(a) 慢 upwelling 舞台(5.44.4 妈) ,(b) 中间速度的 upwelling 舞台(4.43.5 妈) ,(c) 快 upwelling 舞台(3.53.2 妈) ,(d)停止 upwelling 阶段(3.22.7 妈) ,和(e) 快 upwelling 舞台(2.7 妈) 。研究从早上新世(4.7 妈) 在持续时间显示出那到上新世(2.67 妈) 的目的,它持续了 203 万年, Himalaya 山高举了在 0.74 mm/a 的速度的 1500 m;这属于中间速度的 upwelling。在在早更新世的早阶段的 131 万年期间, Himalaya 山在 1.15 mm/a 的速度在另一 1500 m 上面升起了;这是相当快的 upwelling。所有这些数据证明了西方的 Himalaya 山的 upwelling 沿着有 multi-stages,多速度,和非天律不变论的特征的一个复杂过程。 | ZHU Dagang MENG Xian' gang SHAO Zhaogang YANG Chaobin HAN Jian'en YU Jia MENG Qingwei Lü Rongping | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 3 |
| 7 | Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression:the role of adenosine receptor A2显示文摘Hypoxia is a major characteristic of the tumor microenvironment,and its effects on immune cells are proposed to be important factors for the process of tumor immune escape.It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells.Here we discuss the effects of hypoxia on T-cell survival.Our results showed that hypoxia induced apoptosis of T cells.Adenosine and adenosine receptors(AR)are important to the hypoxia-related signaling pathway.Using AR agonists and antagonists,we demonstrated that hypoxia-induced apoptosis of T cells was mediated by A^(2a)and A^(2b)receptors.Furthermore,we are the first,to our knowledge,to report that hypoxia significantly inhibited the expression of chemokine C receptor 7(CCR7)of T cells via the A^(2)R signal pathway,perhaps representing a mechanism of hypoxia-induced apoptosis of T cells.Collectively,our research demonstrated that hypoxia induces T-cell apoptosis by the A^(2)R signaling pathway partly by suppressing CCR7.Blocking the A^(2)R signaling pathway and/or activation of CCR7 can increase the anti-apoptosis function of T cells and may become a new strategy to improve antitumor potential. | Jintang Sun Yan Zhang Meixiang Yang Yun Zhang Qi Xie Zewu Li Zhaogang Dong Yongmei Yang Biping Deng Alei Feng Weixu Hu Haiting Mao Xun Qu | 2010 | Cellular & Molecular Immunology2010，7，1： | 3 |
| 8 | Construction of the Continental Asia in Phanerozoic:A Review显示文摘This is a review of the formation and tectonic evolution of the continental Asia in Phanerozoic.The continental Asia has formed on the bases of some pre-Cambrian cratons,such as the Siberia,India,Arabia,North China,Tarim,South China,and Indochina,through multi-stage plate convergence and collisional collages in Phanerozoic.The north-central Asia had experienced the expansion and subduction of the Paleo-Asian Ocean(PAO)in the early Paleozoic and the closure of the PAO in the late Paleozoic and early Mesozoic,forming the PAO regime and Central Asian orogenic belt(CAOB).In the core of the CAOB,the Mongol-Okhotsk Ocean(MOO)opened with limited expansion in the Early Permian and finally closed in the Late Jurassic–Early Cretaceous.The south-central Asia had experienced mainly multi-stage oceanic opening,subduction and collision evolution in the Tethys Ocean,forming the Tethys regime and Himalaya-Tibetan orogenic belt.In eastern Asia,the plate subduction and continental margin orogeny on western margin of the Pacific Ocean,forms the West Pacific regime and West Pacific orogenic belt.The PAO,Tethys,and West Pacific regimes,together with Precambrian cratons among or surrounding them,made up the major tectonic and dynamic systems of the continental Asia in Phanerozoic.Major tectonic events,such as the Early Paleozoic Qilian,Uralian,and Dunhuang orogeneses,the late Paleozoic East Junggar,Tianshan and West Junggar orogeneses,the Middle to Late Permian Ailaoshan orogeny and NorthSouth Lhasa collision,the early Mesozoic Indochina-South China and North-South China collisions,the late Mesozoic Mongolia-Okhotsk orogeny,Lhasa-Qiangtang collision,and intra-continental Yanshanian orogeny,and the Cenozoic IndoAsian,Arab-Asian,and West Pacific margin collisions,constrained the formation and evolution of the continental Asia.The complex dynamic systems have left large number of deformation features,such as large-scale strike-slip faults,thrustfold systems and extensional detachments on the continental Asia.Based on past tectonics,a future supercontinent,the Ameurasia,is prospected for the development of the Asia in ca.250 Myr. | CHEN Xuanhua DONG Shuwen SHI Wei DING Weicui ZHANG Yiping LI Bing SHAO Zhaogang WANG Ye | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 3 |
| 9 | In-plane coherent control of plasmon resonances for plasmonic switching and encoding显示文摘Considerable attention has been paid recently to coherent control of plasmon resonances in metadevices for potential applications in all-optical light-with-light signal modulation and image processing.Previous reports based on out-ofplane coherent control of plasmon resonances were established by modulating the position of a metadevice in standing waves.Here we show that destructive and constructive absorption can be realized in metallic nano-antennas through in-plane coherent control of plasmon resonances,which is determined by the distribution rule of electricalfield components of nano-antennas.We provide proof-of-principle demonstrations of plasmonic switching effects in a gold nanodisk monomer and dimer,and propose a plasmonic encoding strategy in a gold nanodisk chain.In-plane coherent control of plasmon resonances may open a new avenue toward promising applications in optical spectral enhancement,imaging,nanolasing,and optical communication in nanocircuits. | Liyong Jiang Tingting Yin Alexander M.Dubrovkin Zhaogang Dong Yuntian Chen Weijin Chen Joel K.W.Yang Zexiang Shen | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 10 | Overview of the Mars climate station for Tianwen-1 mission显示文摘The background and scientific objectives of the Mars Climate Station(MCS)for Tianwen-1 are introduced,accompanied by a comparative review of the status of related meteorological observation missions and of advanced sensing technologies.As one of the China Tianwen-1 Mission’s principal scientific payloads,the MCS contains four measurement sensors and one electronic processing unit that are specially designed to measure local temperature,pressure,wind,and sound on the Martian surface.The MCS’s measurement principles,technical schemes,ground calibration techniques,and adaptability evaluation to the Mars surface environment of MCS are introduced in details.The conclusion presents measurement performance specifications of the MCS,based on ground test results,that will provide guidance to future research based on data from the Tianwen-1 and later Mars missions. | YongQing Peng LeiBo Zhang ZhiGuo Cai ZhaoGang Wang HaiLong Jiao DongLi Wang XianTao Yang LianGuo Wang Xu Tan Feng Wang Jing Fang ZhouLu Sun HongLiang Feng XiaoRui Huang Yan Zhu Ming Chen LiangHai Li YanHua Li | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 11 | Recrystallization of the cold-deformed discontinuous precipitation microstructure in Al-Zn (-Cu) alloys显示文摘Reerystallizafion of cold-roUed discontinuous precipitation microstructure which has fine laminar structure in an Al-40% 7m (atom fraction) binary alloy is investigated by optical microscopy, SEM and TEM. It is found that there are two kinds of recrystallization mechanisms: continuous coarsening (CC) and discontinuous coarsening (DC). The latter can be divided into coarsening mainly driven by stored deformation energy at colony boundaries and slip bands and the one mainly driven by boundary energy in the area with little deformation. It is shown that the addition of Cu can retard the nucleation of coarsening cells and their growth. X-Ray diffraction analysis indicated the metastable phase CuZn4 transformed into equilibrium phase Al4Cu3Zn during the heating process. | DINGHua RENYuping HAOShiming WANGDapeng ZHAOGang | 2004 | Rare Metals2004，23，4： | 2 |
| 12 | Uncertain Opinion Evolution with Bounded Confidence Effects in Social Networks显示文摘When people express their opinions for an issue, they can express both exact opinions and uncertain opinions, such as numerical interval opinions. Moreover, social network is a crucial medium of opinion interaction and evolution. In this paper, uncertain opinion evolution with bounded confidence effects in social networks is investigated by theoretical demonstration and numerical examples analyses, and experiments simulations analyses. Theoretical results show when all the agents are with uncertainty tolerances, then the ratios of agents expressing uncertain opinions are impossible to decrease, even increase, as time increases;while when all the agents are without uncertainty tolerances, then the ratios of agents expressing uncertain opinions are impossible to increase, even decrease, as time increases. Moreover, the average widths of uncertain opinions are always smaller than the maximum opinion width of all the initial opinions among agents. Experiments simulations results show different ratios of agents with uncertainty tolerances and different ratios of agents expressing uncertain opinions have strong impact on the ratios of the agents expressing the uncertain opinions in the stable state, and the average widths of uncertain opinions in the stable state. | Min Zhan Haiming Liang Zhaogang Ding Yucheng Dong | 2019 | Journal of Systems Science and Systems Engineering2019，28，4： | 2 |
| 13 | 显示文摘 | HAORui-xia CAOKe-xin ZHAOGang etal(郝瑞霞 曹可心 赵钢 等) | 2006 | 北京工业大学学报2006，32，12： | 2 |
| 14 | A new way to produce alumina with law grade diaspore bauxide 显示文摘 | Meng Zhaogang Zhao Gang | 1998 | Light Metals1998，，12： | 1 |
| 15 | Performance enhancement study of mobile air conditioning system using microchannel heat exehangers显示文摘 | Qi Zhaogang Zhao Yu Chen Jiangping | 2009 | International Journal of Refrigeration2009，33，： | 1 |
| 16 | The role of Gd 2 O 3 and Y 2 O 3 in corrosion of soda lime silicate glass显示文摘 | Mitang Wang Mei Li Jinshu Cheng Feng He Zhaogang Liu Yanhong Hu | 2013 | Journal of Nuclear Materials (-)2013，，1： | 1 |
| 17 | 显示文摘 | XuYan(徐岩) ZhaoGang(赵刚) YangLiming(杨立明)eta1 | 2013 | 功能材料2013，44，： | 1 |
| 18 | Investigating performance of new mini channel evapo rators显示文摘 | Zhaogang Qi Jiangping Chen Reinhard Radermacher | 2009 | Applied Thermal Engineering2009，29，1718： | 1 |
| 19 | Performance enhancement study of mobile air conditioning system using microchannel heat exchangers显示文摘 | QI Zhaogang ZHAO Yu CHEN Jiangping | 2010 | International Journal of Refrigeration2010，33，2： | 1 |
| 20 | Study on separation of rare earth elements in complex system显示文摘 | Hongtao CHANG Mei LI Zhaogang LIU Yanhong HU Fushun ZHANG | 2010 | Journal of Rare Earths2010，，： | 1 |
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