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您的检索式：作者名="Zhengnan Luo"
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| 1 | Mapping Genome-wide Binding Sites of Prox1 in Mouse Cochlea Using the CUT&RUN Approach显示文摘Dear Editor,Our auditory organ,the cochlea,resides in the ventral portion of the inner ear,and its sensory epithelium,the organ of Corti,contains hair cells(HCs)and supporting cells(SCs),which are both descendants of the same progenitors.HCs are prone to damage by multiple ototoxic factors,and how to regenerate damaged HCs using key genes involving cochlear development is of importance[1,2].Cochlear progenitor cells express Sox2 and prolif-erate before embryonic day 12.5(E12.5)in the mouse but become quiescent in an apical-to-basal gradient between E12.5 and E14.5[3]. | Zhengnan Luo Jixiang Zhang Lianyong Qiao Falong Lu Zhiyong Liu | 2021 | Neuroscience Bulletin2021，37，12： | 1 |
| 2 | ARG1 functions as a tumor suppressor in breast cancer显示文摘ArginaseⅠ(ARG1)is a cytosolic enzyme that catalyzes the hydrolysis of Larginine to L-ornithine and urea.The association of ARG1 with cancer has mostly been focused on the ARG1 released by tumor-associated myeloid cells in tumor microenvironment.However,the role of ARG1 expressed in cancer cells is unclear.Here,we showed that the expression of ARG1 in human breast can-cer(BC)is related to a good prognosis in BC patients.Overexpression of ARG1 suppresses BC cell proliferation and migration in vitro and xenograft tumor growth and development in mouse models.Furthermore,ARG1 expression down-regulates the expression of p-AKT,leading to the de-activation of AKT signal pathway in BC cells.Thus,our results established that in contrast to the role of ARG1 released from tumor-associated myeloid cells in tumor microenvironment that promotes tumor immune escape,ARG1 expressed in BC cells suppresses AKT signaling pathway and functions as a tumor suppressor. | Zhengnan Ming Zizheng Zou Kaimei Cai Yi Xu Xueyan Chen Wenjun Yi Junli Luo Zhiyong Luo | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 0 |
| 3 | PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance显示文摘Pre-mRNA processing factor 19(PRPF19)is a multifaceted protein and participates in DNA damage response and pre-mRNA processing.The role of PRPF19 in cancer is unclear.Here,we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis.Overexpression of PRPF19 promotes while knockdown of PRPF19 inhibits tongue cancer cell migration,proliferation,and tumor growth.Overexpression of PRPF19 increases the resistance of tongue cancer cells to radiation and cisplatin treatment.Furthermore,PRPF19 regulates the expression of solute carrier family 40 member 1(SLC40A1)and mono-ADP ribosylhydrolase 2(MACROD2),knockdown of SLC40A1 or MACROD2 decreases the sensitivity of tongue cancer cells to radiation and cisplatin treatment.Thus,our results establish a key role of PRPF19 in tongue cancer growth and chemoradiotherapy resistance,targeting PRPF19 would be an effective therapeutic strategy for tongue cancer,especially for those resistant to chemoradiotherapy. | Yihong He Changhao Huang Kaimei Cai Pei Liu Xueyan Chen Yi Xu Zhengnan Ming Qingqing Liu Qiongxuan Xie Xue Xia Yangqing Sun Junli Luo Rui Wei | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 0 |
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