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| 1 | Serum immunoglobulin A concentration is a reliable biomarker for liver fibrosis in non-alcoholic fatty liver disease显示文摘AIM:To evaluate the diagnostic accuracy of serum Immunoglobulin A(IgA)for differentiating early stage nonalcoholic fatty liver disease(NAFLD)from nonalcoholic steatohepatitis(NASH).METHODS:All cases had fatty liver change confirmed by ultrasound and aminotransferases of at least twice the normal level.Clinical and biochemical data,including serum IgA,were obtained from 50 histologically proven NAFLD cases and 54 healthy controls.Fasting whole blood samples were obtained from the study population.Immunoturbidimetric methods were used to measure the IgA levels.All NAFLD cases were hospitalized for liver biopsy.Liver specimens were examined for steatosis,steatohepatitis and fibrosis within hepatocytes.Patients were categorized into two groups:NASH and non-NASH.Variables were compared within cases(NASH vs non-NASH)and controls.Cut-off values of serum IgA were evaluated using analysis of receiver operating characteristic(ROC curves).Associations between the variables were tested using calculations of correlation coefficients.Statistical significances were assigned to P values<0.05.RESULTS:The extent of liver fibrosis correlated positively with IgA levels.Subjects with no fibrosis in their liver biopsies had a lower IgA level(301.5±91.2 mg/dL)than subjects with any degree of fibrosis(388.8±140.8 mg/dL),(P=0.01).IgA levels were higher in NASH cases,and its value was significantly higher for higher degrees of fibrosis.Patients with perisinusoidal or pericellular fibrosis had significantly higher levels of IgA(403.5±133.9 mg/dL,418.2±129.5 mg/dL)compared to those without it(301.8±94.9 mg/dL,297.7±91.5 mg/dL),respectively.No significant correlation was found between steatosis grade and serum IgA levels.Based on ROC analysis,the best predictive IgA cutoff value for detecting liver fibrosis was 360mg/dL(61%sensitivity,81%specificity).CONCLUSION:The serum IgA level is useful to evaluate the severity of liver fibrosis and can be used serially for evaluation and follow-up of NAFLD cases. | Iradj Maleki Mahmood Reza Aminafshari Tarang Taghvaei Vahid Hosseini Alireza Rafiei Zhila Torabizadeh Maryam Barzin Elahe Orang | 2014 | World Journal of Gastroenterology2014，20，35： | 4 |
| 2 | Lipids of the green alga Botryococcus cultured in a batch mode显示文摘 | Kalacheva G S Zhila N O Volova T G | 2001 | Microbiology2001，70，3： | 1 |
| 3 | Co-prescription of Gastroprotective Agents and Their Efficacy in Elderly Patients Taking Nonsteroidal Anti-inflammatory Drugs: A Systematic Review of Observational Studies显示文摘 | Stephanie Medlock Saeid Eslami Marjan Askari Zhila Taherzadeh Dedan Opondo Sophia E. de Rooij Ameen Abu–Hanna | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 4 | Glucose variability measures and their effect on mortality:a systematic review显示文摘 | Saeid E Zhila T Marcus J | 2011 | Intensive care med2011，37，： | 1 |
| 5 | Preparation of various xanthene derivatives over sulfonic acid functionalized imidazolium salts (SAFIS) as novel, highly efficient and reusable catalysts显示文摘 | Mohammad Ali Zolfigol Vahid Khakyzadeh Ahmad Reza Moosavi-Zare Abdolkarim Zare Seyedeh Bahareh Azimi Zhila Asgari Alireza Hasaninejad | 2012 | Comptes rendus - Chimie2012，，8： | 1 |
| 6 | Organocatalyst trityl chloride efficiently promoted the solvent-free synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[ a ]-xanthen-11-ones by in situ formation of carbocationic system in neutral media显示文摘 | Ardeshir Khazaei Mohammad Ali Zolfigol Ahmad Reza Moosavi-Zare Abdolkarim Zare Mahmoud Khojasteh Zhila Asgari Vahid Khakyzadeh Ali Khalafi-Nezhad | 2012 | Catalysis Communications2012，，： | 1 |
| 7 | Influence of nitrogen deficiency on biochemical composition of the green alga Botryococ- cus 显示文摘 | Zhila N O Kalacheva G S Volova T G | 2005 | Journal of Applied Phycology2005，17，4： | 1 |
| 8 | The effect of temperature on the lipid composition of the green alga Botryococcus 显示文摘 | KALACHEVA G S ZHILA N O VOLOVA T G | 2002 | Microbiology2002，71，3： | 1 |
| 9 | A temperature dependence of the intra-and extracellular fatty-acid composition of green algae and cyanbacterium显示文摘 | Sushchik N N Kalacheva G S Zhila N O | 2003 | Russian Journal of Plant Physiology2003，50，3： | 1 |
| 10 | Problems of Clinical Nurse Performance Appraisal System : A Qualitative Study 显示文摘 | Nasrin Nikpeyma Zhila Abed Saeedi Eznollah Azargashb | 2014 | Asian Nursing Research2014，8，1： | 1 |
| 11 | Effect of nitrogen limitation on the growth and lipid composition of the green alga Botryococcus braunii Kutz IPPAS H-252显示文摘 | Zhila N Kalaeheva G Volova T | 2005 | Russ J Plant Physiol2005，52，3： | 1 |
| 12 | Tracking Bacillus cereus in UF-feta cheese processing line显示文摘 | ZHILA M K HAMID E YAHYA M | 2014 | International Dairy Journal2014，39，： | 1 |
| 13 | Specificity of lipid composition in two Botryococcus strains, the producers of liquid hydrocarbons 显示文摘 | Volova TG Kalacheva GS Zhila NO | 2003 | Russ J Plant Physl2003，50，5： | 1 |
| 14 | Problems of Clinical Nurse Performance Appraisal System: A Qualitative Study显示文摘 | Nasrin Nikpeyma Zhila Abed Saeedi Eznollah Azargashb Hamid Alavi Majd | 2013 | Asian Nursing Research2013，，： | 1 |
| 15 | Influence of nitrogen deficiency on biochemical composition of the green alga Botryococcus显示文摘 | Zhila N O Kalacheva G S and Volova T G | 2005 | Journal of Applied Phycology2005，17，4： | 1 |
| 16 | Effect of nitrogen limitation on the growth and lipid composition of the green alga Botryococcus braunii Kütz IPPAS H-252 Russian显示文摘 | ZHILA N O KALACHEVA G S VOLOVA T G | 2005 | Journal of Plant Physiology2005，52，3： | 1 |
| 17 | Lipid and hydrocarbon compositions of a collection strain and a wild sample of the green microalga Botryococcus显示文摘 | Kalaeheva G S Zhila N O Volova T G | 2002 | Aquatic Ecology2002，36，： | 1 |
| 18 | Correlation between vitamin D3 deficiency and insulin resistance in pregnancy显示文摘 | ZHILA M ARASH H FARZANEH K | 2008 | Diabetes Metab Res Rev2008，24，： | 1 |
| 19 | Problems of clinical nurse performance appraisal system:a qualitative study显示文摘 | Nasrin N Zhila ASE | 2014 | Asian Nurs Res2014，8，1： | 1 |
| 20 | The effect of temperature on the lipid composition of the green alga Botryococcus显示文摘 | Kalacheva G S Zhila N O Volova T G | 2002 | Microbiology2002，71，3： | 1 |
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