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您的检索式：作者名="Zhiling Xiang"
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| 1 | Elastic hydrogen-bonded ionic framework显示文摘Elasticity,as an emerging phenomenon of crystals,endows the newfangled properties on crystals owing to the altered local crystallinity in the deformed state,and hence attracts increasing research endeavors.However,only a few molecular crystals and a limited number of one-dimensional coordination polymer crystals have exhibited such fantastic elastic response under mechanical stress.Herein,we report the first example of elastic hydrogen-bonded ionic framework(HIF)of{(CN_(3)H_(6))_(2)[Ti(μ_(2)-O)(SO_(4))_(2)]}n,assembled from one-dimensional negatively charged inorganic[Ti(μ_(2)-O)(SO_(4))_(2)]n 2n-chains and positively charged organic guanidinium cations via hydrogen bonds and electrostatic interactions.The slender prismatic single crystal exhibits remarkable elasticity with an optimal elastic bending strain(ε)of 2.5%.Impressively,the crystals give rise to two-dimensional elasticity owing to the equivalent crystallographic planes of the exposed faces and an unusual elastic response at liquid nitrogen temperature.The in-depth crystallographic analyses reveal hydrogen bonds and electrostatic interactions between anion chains and cations function like adhesive glue and account for such specific elastic properties,owing to the flexible and dynamic attributes of hydrogen bonds as they can work in a range of distance and orientation.And the channel in HIF provides space for bending with reduced strain.Incorporating these factors into low-dimensional crystals could be a general guidance for designing elastic crystals.Elasticity ganged with other intrinsic properties of HIF materials could inspire their newfangled applications in the near future. | Congyan Liu Fei Ye Zhiling Xiang Yan Wang Tian Zhang Bo Liu | 2023 | Nano Research2023，16，7： | 0 |
| 2 | CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease显示文摘Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function. | Xiang Chen Yuwan Lin Zhiling Zhang Yuting Tang Panghai Ye Wei Dai Wenlong Zhang Hanqun Liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin Zhu Zhuohua Wu Yaoyun Kuang Pingyi Xu Miaomiao Zhou | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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