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| 1 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | Ripple-associated high-firing interneurons in the hippocampal CA1 region显示文摘By simultaneously recording the activity of individual neurons and field potentials in freely behaving mice, we found two types of interneurons firing at high frequency in the hippocampal CA1 region, which had high correlations with characteristic sharp wave-associated ripple oscillations (100―250 Hz) during slow-wave sleep. The firing of these two types of interneurons highly synchronized with ripple oscillations during slow-wave sleep, with strongly increased firing rates corresponding to individual ripple episodes. Interneuron type I had at most one spike in each sub-ripple cycle of ripple episodes and the peak firing rate was 310±33.17 Hz. Interneuron type II had one or two spikes in each sub-ripple cycle and the peak firing rate was 410±47.61 Hz. During active exploration, their firing was phase locked to theta oscillations with the highest probability at the trough of theta wave. Both two types of interneurons increased transiently their firing rates responding to the startling shake stimuli. The results showed that these two types of high-frequency interneurons in the hippocampal CA1 region were involved in the modulation of the hippocampal neural network during different states. | WANG Ying, ZHANG Lu, PAN JingWei, XIE Kun, LI ShiQi, WANG ZhiRu & LIN LongNian Key Laboratory of Brain Functional Genomics of Ministry of Education, East China Normal University, Shanghai 200062, China | 2008 | Science China(Life Sciences)2008，51，2： | 3 |
| 3 | GABAergic Interneurons are Required for Generation of Slow CA1 Oscillation in Rat Hippocampus显示文摘Neuronal oscillations are fundamental to hippocampal function. It has been shown that GABAergic interneurons make an important contribution to hippocampal oscillations, but the underlying mechanism is not well understood. Here, using whole-cell recording in the complete hippocampal formation isolated from rats at postnatal days 14–18, we showed that GABA_Areceptormediated activity enhanced the generation of slow CA1 oscillations. In vitro, slow oscillations(0.5–1.5 Hz) were generated in CA1 neurons, and they consisted primarily of excitatory rather than inhibitory membrane-potential changes. These oscillations were greatly reduced by blocking GABA_Areceptor-mediated activity with bicuculline and were enhanced by increasing such activity with midazolam, suggesting that interneurons are required for oscillation generation. Consistently, CA1 fast-spiking interneurons were found to generate action potentials usually preceding those in CA1 pyramidal cells. These findings indicate a GABA_Areceptor-based mechanism for the generation of the slow CA1 oscillation in the hippocampus. | Yuan Xu Lidan Wang Yu-zhang Liu Yan Yang Xiaolin Xue Zhiru Wang | 2016 | Neuroscience Bulletin2016，32，4： | 3 |
| 4 | The performance of supply chain inventory management under step-deterministic demand显示文摘 | Xiaoling Xu Haiyan Wang and Zhiru Juan | 2013 | ICIC Express Letters2013，7，3： | 1 |
| 5 | Dependence of Generation of Hippocampal CAI Slow Oscillations on Electrical Synapses显示文摘Neuronal oscillations in the hippocampus are critical for many brain functions including learning and memory.The underlying mechanism of oscillation generation has been extensively investigated in terms of chemical synapses and ion channels.Recently,electrical synapses have also been indicated to play important roles,as reported in various brain areas in vivo and in brain slices.However,this issue remains to be further clarified,including in hippocampal networks.Here,using the completely isolated hippocampus,we investigated in vitro the effect of electrical synapses on slow CA1 oscillations(0.5 Hz-1.5 Hz)generated intrinsically by the hippocampus.We found that these oscillations were totally abolished by bath application of a general blocker of gap junctions(carbenoxolone)or a specific blocker of electrical synapses(mefloquine),as determined by whole-cell recordings in both CA1 pyramidal cells and fast-spiking cells.Our findings indicate that electrical synapses are required for the hippocampal generation of slow CA1 oscillations. | Yuan Xu Feng-Yan Shen Yu-Zhang Liu Lidan Wang Ying-Wei Wang Zhiru Wang | 2020 | Neuroscience Bulletin2020，36，1： | 1 |
| 6 | Inhibi- tion of foot-and-mouth disease virus replication in vitro and in vivo by small interfering RNA 显示文摘 | WANG Pengyan REN Yan GUO Zhiru | 2008 | Virol J2008，5，： | 1 |
| 7 | A covalent attraction between two molecular cation TTF·^+显示文摘The optimized structure of the tetrathiafulvalence radical-cation dimer(TTF·+-TTF·+) with all-real frequencies is obtained at MP2/6-311G level,which exhibits the attraction between two molecular cation TTF·+.The new attraction interaction is a 20-center-2-electron intermolecular covalent π /π bonding with a telescope shape.The covalent π /π bonding has the bonding energy of about -21 kcal·mol-1 and is concealed by the Coulombic repulsion between two TTF·+ cations.This intermolecular covalent attraction also influences the structure of the TTF·+ subunit,i.e.,its molecular plane is bent by an angle θ=5.6°.This work provides new knowledge on intermolecular interaction. | WANG FangFang WANG Yi WANG BingQiang WANG YinFeng MA Fang Li ZhiRu | 2009 | Science China Chemistry2009，52，11： | 1 |
| 8 | Imitating trumpet shells: Mbius container molecules显示文摘Mbius container molecules C64H8,C60N4H4,and C58N6H2 with topological one-sided characteristics were constructed at the first time by imitating natural trumpet shells.The structure is an open cage with an inner hexagonal bridge.The bridge joints the outer and inner surfaces of the cage to form a new one-sided Mbius structure.The optimized structures of the three molecules in the singlet(the ground state),triplet and quintet states are obtained using the density functional theory(B3LYP).For the ground state structures of the three Mbius molecules,their oxidizabilities are weaker than that of the C60 and reducibilities are close to that of the stable C80 cage and slightly stronger than that of the C60.These may show that the unusual Mbius structures have some stability.Their potential properties were predicted,for example,the special aromaticity of the bridge ring due to the unique interaction between the bridge and the cage wall.These findings enlarge the knowledge of Mbius molecules. The idea of bionic and topological imitating in chemistry may promote the design of new complex-shaped nano-molecules and molecular devices. | MA Fang WANG FangFang LI ZhiRu WU Di LI ZeSheng GU FengLong | 2011 | Science China Chemistry2011，54，3： | 0 |
| 9 | Generation and Discharge of Pollutants in Closed Aquaculture显示文摘[Objectives]To gain an in-depth understanding of pollutant generation and discharge from closed aquaculture.[Methods]In 2018,the pollutant generation and discharge coefficients of 7 farming modes in 16 farming bases were calculated and analyzed.[Results]A total of 28 pollutant generation coefficients and 28 pollutant discharge coefficients were obtained,and the generation and discharge of pollutants in closed aquaculture were grasped preliminarily.Compared with the data of the first census of pollutions sources published by the state in 2008,7 kinds of pollution generation coefficients increased,while 14 kinds decreased;and 4 kinds of pollutant discharge coefficients increased,while 17 kinds decreased.[Conclusions]In recent years,the pollutant generation and discharge coefficients of aquaculture show a decreasing trend. | Wansheng SUN Zhiru FU Jie YU Ling ZHANG Baofeng WANG | 2022 | Asian Agricultural Research2022，14，4： | 0 |
| 10 | Excitatory Crossmodal Input to a Widespread Population of Primary Sensory Cortical Neurons显示文摘Crossmodal information processing in sensory cortices has been reported in sparsely distributed neurons under normal conditions and can undergo experience-or activity-induced plasticity.Given the potential role in brain function as indicated by previous reports,crossmodal connectivity in the sensory cortex needs to be further explored.Using perforated whole-cell recording in anesthetized adult rats,we found that almost all neurons recorded in the primary somatosensory,auditory,and visual cortices exhibited significant membrane-potential responses to crossmodal stimulation,as recorded when brain activity states were pharmacologically down-regulated in light anesthesia.These crossmodal cortical responses were excitatory and subthreshold,and further seemed to be relayed primarily by the sensory thalamus,but not the sensory cortex,of the stimulated modality.Our experiments indicate a sensory cortical presence of widespread excitatory crossmodal inputs,which might play roles in brain functions involving crossmodal information processing or plasticity. | Yuan-Jie Xiao Lidan Wang Yu-Zhang Liu Jiayu Chen Haoyu Zhang Yan Gao Hua He Zheng Zhao Zhiru Wang | 2022 | Neuroscience Bulletin2022，38，10： | 0 |
| 11 | Multiple Trajectories of Cereal Consumption and Their Associations with Type 2 Diabetes in Chinese Adults-China,1997-2018显示文摘Summary What is already known about this topic?Consuming refined grains,specifically white rice,elevates the risk of developing type 2 diabetes(T2D).Conversely,incorporating whole grains into the diet is linked to a reduced risk.What is added by this report?This study employed a novel multi-trajectory modeling technique to account for the intercorrelations among various cereal consumption patterns. | Mengran Liu Zhiru Wang Feifei Huang Weiyi Li Zhihong Wang Huijun Wang Gangqiang Ding | 2023 | China CDC weekly2023，5，41： | 0 |
| 12 | NAD^(+) and its possible role in gut microbiota:Insights on the mechanisms by which gut microbes influence host metabolism显示文摘Nicotinamide adenine dinucleotide(NAD^(+))is an enzyme cofactor,co-substrate,and redox factor in all living cells and is necessary for maintaining cell metabolism.It has been shown that appropriate supplementation of NAD^(+)precursors or inhibition of NAD^(+)-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency.In addition,increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism.Theoretically,there should be a close correlation among NAD^(+),gut microbiota,and host metabolism;however,the information is limited.In this review,we summarize the metabolic process of NAD^(+)and its impact on host metabolism,the link between gut microbiota and host metabolism,as well as the potential effects of NAD^(+)on microbial metabolism,providing a new perspective on the interaction between gut microbiota and host metabolism. | Zhongxiang Ren Yetong Xu Tiejun Li Weizhong Sun Zhiru Tang Yongsheng Wang Kaifeng Zhou Jigang Li Qi Ding Kaiyang Liang Liuting Wu Yulong Yin Zhihong Sun | 2022 | Animal Nutrition2022，，3： | 0 |
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