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| 1 | Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/ eIF2a/ATF4/CHOP Signaling Pathway显示文摘Apoptosis induced by endoplasmic reticulum(ER)stress plays a crucial role in mediating brain damage after ischemic stroke.Recently,Hes1(hairy and enhancer of split 1)has been implicated in the regulation of ER stress,but whether it plays a functional role after ischemic stroke and the underlying mechanism remain unclear.In this study,using a mouse model of ischemic stroke via transient middle cerebral artery occlusion(tMCAO),we found that Hes1 was induced following brain injury,and that siRNA-mediated knockdown of Hes1 increased the cerebral infarction and worsened the neurological outcome,suggesting that Hes1 knockdown exacerbates ischemic stroke.In addition,mechanistically,Hes1 knockdown promoted apoptosis and activated the PERK/eIF2a/ATF4/CHOP signaling pathway after tMCAO.These results suggest that Hes1 knockdown promotes ER stress-induced apoptosis.Furthermore,inhibition of PERK with the specific inhibitor GSK2606414 markedly attenuated the Hes1 knockdown-induced apoptosis and the increased cerebral infarction as well as the worsened neurological outcome following tMCAO,implying that the protection of Hes1 against ischemic stroke is associated with the amelioration of ER stress via modulating the PERK/eIF2a/ATF4/CHOP signaling pathway.Taken together,these results unveil the detrimental role of Hes1 knockdown after ischemic stroke and further relate it to the regulation of ER stress-induced apoptosis,thus highlighting the importance of targeting ER stress in the treatment of ischemic stroke. | Yueyong Li Yingjun Zhang Huangde Fu Huadong Huang Qifeng Lu Houji Qin Yingning Wu Huatuo Huang Guizhen Mao Zhongheng Wei Pinhu Liao | 2020 | Neuroscience Bulletin2020，36，2： | 12 |
| 2 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 3 | Value of Multi-slice spiral CT in diagnosis of malignant gastrointestinal stromal tumors显示文摘这研究的目的是在恶意的胃肠的 stromal 肿瘤(大意) 的诊断调查多片螺线 CT (MSCT ) 的价值的目的。恶意的大意的 MSCT 图象的 27 个案例由外科和病理证明了的方法回顾地被分析。平原和提高的 CT 扫描被执行,多平面的重建在所有情况中被做。结果损害从胃发源(n = 11 ) ,小肠(n = 9 ) ,结肠(n = 4 ) ,直肠(n = 1 ) ,并且肠系膜(n = 2 ) 。质量的横向的直径是 4.2 22 厘米,边清楚地(n = 12 ) ,不清楚地(n = 15 ) 。团在形状 lobulated 主要是不规则的(n = 19 ) 。损害主要是平凡扫描上的异质,对在动脉的阶段的显著改进中等、持续性在静脉的阶段提高了。膀胱的坏死在所有损害被观察, 9 个案例是膀胱、稳固的混合质量。肝的转移(n = 4 ) ,肺的转移(n = 1 ) ,淋巴的转移(n = 2 ) 被检测。为地点和大意的病理学的特征的 MSCT 诊断的精确性率是 85.2%(23/27 ) 并且 77.8%(21/27 ) 。与多平面的重建图象相结合的结论二阶段的 MSCT 检查和轴的图象为恶意的大意的诊断有重要价值。 | Zhongheng He Fajin Lv Zhaofei Cao Mingxia Qian | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 5 |
| 4 | ON THE CLASSIC NONHOLONOMIC DYNAMICS显示文摘For first-order nonlinear nonholonomic systems,the present paper proves that thed-δ operations are commutative and derives the equation of motion without making use of the additional Appell-Chetaev condition.This equation of motion coincides with the equation of'Vacco dynam-ics'. | Guo Zhongheng Gao Puyun~(2))(Department of Mathematics,Peking University) 2)At present,Dept.of Mathematics,Xiantan Normal School. | 1989 | Acta Mechanica Sinica1989，5，3： | 4 |
| 5 | Survey of Occurrence and Damage of Xylotrechus quadripes Chevr on Simao Coffee in Pu'er City显示文摘The occurrence and damage of Xylotrechus quadripes Chevr were investigated in different time points and micro environments in Simao south island river coffee test demonstration field. The results showed that X. quadripes mainly damaged 5-year-old coffee trees. X. quadripes occurred one generation per year in Simao region,and the larval stage lasted 296-322 d. The adult could be found in four seasons because of different development progress and overlapping generations. In different micro environments,X. quadripes were mainly distributed in mixed forests and the coffee land in sunny slope. The adult enjoyed sunshine on the coffee trees at noon. The natural enemy Prislauacus nigripea kieff was found to parasitize in the larvae of X. quadripes,which could control the population of X. quadripes. | Shu Mei Cheng Wenzhang Li Zhongheng Qiang Jiye Jiang Zhilin | 2016 | Plant Diseases and Pests2016，7，5： | 2 |
| 6 | Cystatin C in Prediction of Acute Kidney Injury: A Systemic Review and Meta-analysis显示文摘 | Zhongheng Zhang Baolong Lu Xiaoyan Sheng Ni Jin | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 7 | Conformations of stilbene-like species and new method of energy partition显示文摘 | Yu Zhongheng Li Lintong Fu Wei | 1998 | J Phys Chem A1998，102，： | 2 |
| 8 | Harmonic Resonance Phenomena in STATCOM and Relationship to Parameters Selection of Passive Components 显示文摘 | Shen Dong Wang Zhongheng J Y Chen | 2001 | IEEE Transactions on Power Delivery2001，16，1： | 1 |
| 9 | Ultrasonographicmeasurement of the respiratory variation in the inferior vena cavadiameter is predictive of fluid responsiveness in critically ill pa-tients :systematic review and meta-analysis显示文摘 | ZHANG Zhongheng XU Xiao YE Sheng | 2014 | Ultrasound MedBiol2014，40，5： | 1 |
| 10 | A single nucleotide polymorphism in XRCC4 gene is associated with reduced colorectal cancer susceptibility in female显示文摘Objective:To investigate the association of XRCC4 polymorphic variants at G-1394T(rs6869366) with colorectal cancer susceptibility.Methods:In this hospital-based case-control study,the association of XRCC4 polymorphism with colorectal cancer risk in Chinese population was investigated.In total,171 patients with colorectal cancer and 171 healthy individuals matched for age and gender were selected.The genomic DNAs of the patients and controls were extracted from peripheral blood and the 300 bp target DNA was amplified with Polymerase Chain Reaction.The products were then digested with restriction endonuclease HincII,followed by agarose electrophoresis to identify the genotype.Results:We found a significant difference in the frequency of the XRCC4 G-1394T genotype between the colorectal cancer and control groups in female(1/127 vs 8/122,P<0.05).Those with G/T at XRCC4 G-1394T showed a decreased risk of colorectal cancer susceptibility compared with those with T/T(OR 0.113,95%CI 0.014-0.932).However,in overall population or in male,there was no significant difference of the distribution between the colorectal cancer and control groups.Conclusion:Our findings suggested that the G allele of XRCC4 G-1394T were associated with decreased risk of colorectal cancer susceptibility in female. | Zhang Zhongheng Hu Weiling | 2011 | Journal of Medical Colleges of PLA(China)2011，26，2： | 1 |
| 11 | Do the observational studies using propensity score analysis agree with randomized controlled trials in the area of sepsis?显示文摘 | Zhongheng Zhang Hongying Ni Xiao Xu | 2014 | Journal of Critical Care2014，，： | 1 |
| 12 | Observational studies using propensity score analysis underestimated the effect sizes in critical care medicine显示文摘 | Zhongheng Zhang Hongying Ni Xiao Xu | 2014 | Journal of Clinical Epidemiology2014，，： | 1 |
| 13 | Hydrothermal-treated Pt/Al_(2)O_(3) as an excellent catalyst for toluene total oxidation显示文摘The preparation of highly active supported noble metal catalysts with a low noble metal loading has always been the ultimate goal of researchers working on catalysis.Hydrothermally treated Pt/Al_(2)O_(3)(Pt/Al_(2)O_(3)-H)exhibits better catalytic activity than that(Pt/Al_(2)O_(3)-C)treated via the conventional calcination approach.At the high space velocity of100,000 m L/(g·hr),the temperature that correspond to 50%toluene conversion(T50)of Pt/Al_(2)O_(3)-H is 115℃ lower than that of Pt/Al_(2)O_(3)-C,and the turnover frequency(TOF)value can reach 0.0756 sec-1.The mechanism by which the hydrothermal approach enhances Pt/Al_(2)O_(3) activity has been investigated.The structure associated with the high catalytic activity of Pt nanoparticles(NPs)can be retained via hydrothermal treatment.Furthermore,the support is transformed to AlO(OH)with numerous surface hydroxyl groups,which in turn can facilitate the adsorption of toluene.And the synergistic effects of Pt NPs and AlO(OH)increases the contents of Pt in oxidation state and active oxygen,which are beneficial for toluene oxidation. | Xiao Chen Yong Wang Jianyu Li Zhongheng Hu Ying Zhou Huayan Liu Hanfeng Lu | 2022 | Journal of Environmental Sciences2022，34，6： | 1 |
| 14 | Quantum corrections to the entropy of a Reissner-Nordstrǎm black hole due to spin fields 显示文摘 | | 2000 | Phys Rev2000，62，02： | 1 |
| 15 | Quantum correction to the entropy of a Beissner - Nordstrom black hole due to spin fields显示文摘 | Li Zhongheng | 1999 | Phys Bey1999，62，02： | 1 |
| 16 | Efficacy and safety of regional citrateanticoagulation in critically ill patients undergoing con- tinuous renal replacement therapy显示文摘 | Zhongheng Zhang Ni Hongying | 2012 | Intensive Care Med2012，38，1： | 1 |
| 17 | Quantum correcting to the entropy of a Barriola - Vilenkin black hole due to spin fields显示文摘 | Li Zhongheng | 2000 | Chin Phys lett2000，17，6： | 1 |
| 18 | Recombinant human activated protein C for the treatment of severe sepsis and septic shock:a study protocol for incorporating observational evidence using a Bayesian approach显示文摘 | Zhongheng Zhang | 2014 | BMJ Open2014，4，7： | 1 |
| 19 | Use of the PiCCO system in critieally ill patients with septic shock and acute respiratory distress syndrome: study protocol for a randomized controlled tria1显示文摘 | Zhongheng Zhang Xiao Xu Min Yao et a1 | 2013 | Trials2013，14，： | 1 |
| 20 | A novel energy partition for gaining new insight into aromaticity and conjugation显示文摘 | Yu Zhongheng Xuan Zhengqian Wang Tongxin | 2000 | J Phys Chem A2000，104，： | 1 |
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