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| 1 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 2 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 3 | The effect of dynamic posterior stabilization on facet joint contact forces:an in vitro investigation显示文摘 | Niosi CA Wilson DC Zhu Q | 2008 | Spine2008，33，1： | 1 |
| 4 | Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: the requirement of extracellular signal-regulated kinase, p38, c- Jun N-terminal kinase and NF-kappaB pathways for the expression of proinflammatory eytokines and nitric oxide显示文摘 | Zhu J Krishnegowda G Gowda DC | 2005 | J Biol Chem2005，280，9： | 1 |
| 5 | Glutaraldehyde-fixed bioprosthetic heart valve conduits calcify and fail fro xenograft rejection显示文摘 | Manji RA Zhu LF Nijjar NK Rayner DC Korbutt GS Churchill TA | | 0，，04： | 1 |
| 6 | Protection against titanium particle-induced osteoclastogenesis by cyclooxygenase- 2 selective inhibitor 显示文摘 | Gong DC Zhu XS Mao HQ | 2011 | J Biomed Mater Res A2011，99，4： | 1 |
| 7 | Carnosine inhibits pentyIenetetrazol - induced seizures by histaminergicmechanisms in histidine decarboxylase knock - out mice 显示文摘 | Zhu YY Zhu -Ge ZB Wu DC | 2007 | Neurosci Lett2007，416，3： | 1 |
| 8 | Biomechanical characterization of the three-dimensional kinematic behaviour of the dynesys dynamic stabilization system:an in vitro study显示文摘 | Niosi CA Zhu QA Wilson DC | 2006 | Eur Spine J2006，15，6： | 1 |
| 9 | Biomechanical characterizationof the three-dimensional kinematic behaviour of the Dynesys dynam-ic stabilization system : an in vitro study 显示文摘 | Niosi CA Zhu QA Wilson DC | 2006 | Eur Spine J2006，15，6： | 1 |
| 10 | Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages 显示文摘 | Kamat M E1-Boubbou K Zhu DC | 2010 | Bioconjug Chem2010，21，11： | 1 |
| 11 | High resolution analysis of genomic aberrations by memphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines显示文摘 | Zhu H Lam DC Han KC | | 0，，： | 1 |
| 12 | Preliminary study of the types of traumatic peripheral nerve injuries by ultrasound显示文摘 | Zhu JA Liu F Li DC | 2011 | Eur Radiol2011，21，5： | 1 |
| 13 | High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines显示文摘 | Zhu H Lam DC Han KC | | 0，，1： | 1 |
| 14 | Biomechanical character- ization of the three-dimensional kinematic behaviour of the Dyne- sys dynamic stabilization system: an in vitro study显示文摘 | Niosi CA Zhu QA Wilson DC | 2006 | Eur SpineJ2006，15，6： | 1 |
| 15 | The effect of dynamic posterior stabilization on facet joint contact forces: an in vitro investigation显示文摘 | Niosi CA Wilson DC Zhu Q | 2008 | Spine2008，33，1： | 1 |
| 16 | Activation of Mpsl Promotes Transforming Growth Factor-beta-independent Smad Signaling显示文摘 | Zhu S Wang W Clarke DC | | 0，，25： | 1 |
| 17 | Me CP2 Controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis显示文摘 | Mann J Chu DC Maxwell A Oakley F Zhu NL Tsukamoto H | 2010 | Gastroenterology2010，138，2： | 1 |
| 18 | The effect of dynamic pos- terior stabilization on facet joint contact forces: an in vitro investi- gation显示文摘 | Niosi CA Wilson DC Zhu Q | 2008 | Spine (Phila Pa 1976)2008，33，1： | 1 |
| 19 | Biomechanical characterization of the three-dimensional kinematic behaviour of the Dynesys dynamic stabilization system: an in vitro study显示文摘 | Niosi CA Zhu QA Wilson DC | 2006 | Eur Spine J2006，15，6： | 1 |
| 20 | Formation and structure of cross link in and monomeric pyrroleautoxidation productsin 2,5 - hexanedione-treated aminoacids, peptides, and protein 显示文摘 | Zhu M Spink DC Yan B | 1994 | Chem Res Toxicol1994，7，4： | 1 |
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