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| 1 | Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival. | Loukia S Poulou Evanthia Botsa Ioanna Thanou Panayiotis D Ziakas Loukas Thanos | 2015 | World Journal of Hepatology2015，7，8： | 37 |
| 2 | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis显示文摘BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (ETs) are related to the pathophysiology of PPHT.The study aimed to measure serum ET levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient outcome.METHODS:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler echocardiography.Patients with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time <100 ms were deemed to have PPHT.ET-1,2,and 3 serum levels were measured with an ELISA assay.All-cause mortality was recorded over a median period of 24 months.RESULTS:Nine out of 57 patients (15.8%) had PPHT.Among various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).ET-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the ET-1/ET-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those without.ET-2 and ET-3 levels did not differ between the two groups.There was no difference in survival between the two groups,although ET-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in ET-1).CONCLUSION:Our data suggest that ET-1 and the ET-1/ET-3 ratio are elevated in patients with PPHT and that ET-1 is associated with a poor outcome irrespective of PPHT. | Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas George E Tzelepis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 3 | Reduction of the estimated radiation dose and associated patient risk with prospective ECG-gated 256-slice CT coronary angiography显示文摘 | E P Efstathopoulos N L Kelekis I Pantos E Brountzos S Argentos J Grebá? D Ziaka D G Katritsis I Seimenis | 2009 | Physics in Medicine and Biology2009，，17： | 1 |
| 4 | Effect of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in lymphoma:a meta-analysis of published clinical trials and a decision tree addressing prolonged prophylaxis and maintenance显示文摘 | ZIAKAS P D KARSALIAKOS P MYLONAKIS E | 2009 | Haematologica2009，94，7： | 1 |
| 5 | Thrombophilia and venous thromboembolism in pregnancy: a meta-analysis of genetic risk显示文摘 | Ziakas P D Poulou L S Pavlou M | 2015 | Eur J Obstet Gynecol Reprod Biol2015，191，2： | 1 |
| 6 | Anaemia in systemiclupus erythematosus:from pathophysiology to clinical assessment显示文摘 | Giannouli S Voulgarelis M Ziakas P D | 2006 | Ann RheumDis2006，65，2： | 1 |
| 7 | Endogenous group G streptococcus endophthalmitis following a dental procedure 显示文摘 | Ziakas NG Tzetzi D Boboridis K | 2004 | Eur J Ophthalmol2004，14，1： | 1 |
| 8 | Effect of prophylactic lami- vudine for chemotherapy - associated hepatitis B reactivation in lymphoma : a meta - analysis of published clinical trials and a deci- sion tree addressing prolonged prophylaxis and maintenance 显示文摘 | Ziakas D Karsaliakos P Mylonakis E | 2009 | ttaematologiea2009，94，7： | 1 |
| 9 | Effect of prophylactic lamuvidine for chemotherapy-asso ciated hepatitis B reactivation reactivation in lymphoma:a meta-analysis of published clinical trials and a decision tree addressing prolonged prophylaxis and maintenance 显示文摘 | ZIAKAS P D KARSALIAKOS P MYLONAKIS E | 2009 | Haematologiea2009，94，： | 1 |
| 10 | Anaemia in systemic lupus erythematosus:from pathophysiology to clinical assessment显示文摘 | GIANNOULI S VOULGARELIS M ZIAKAS P D | 2006 | Ann Rheum Dis2006，65，2： | 1 |
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