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| 1 | Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial显示文摘AIM: To evaluate the safety and efficacy of oral administration of AlequelTM, an autologous proteincontaining colon extract.a randomized,placebo-controlled,double-blind trial.Patients were orally administered with autologous protein-containing colon extract three doses of autologous study drug per week for 15 wk,for a total of45 doses.Patients were followed for safety parameters.Remission was defined as a Crohn’s disease activity index(CDAI)score of less than or equal to 150.All patients were followed for changes in subsets of T cells by fluorescence-activated cell sorting analysis.RESULTS:Analysis was performed on a total number of evaluable patients of 14 in the study drug group and15 in the placebo group.Treatment was well tolerated by all patients.No major treatment-related adverse events were reported or observed in any of the treated patients during the feeding or follow-up periods.Between weeks 6 and 9 of the study,six of the 14(43%)evaluable subjects who received the study drug achieved a CDAI of 150 or lower.In contrast,five of the 15(33%)evaluable subjects in the placebo group achieved remission.Between weeks 9 and 12,the remission rates were 50%and 33%for the drug group and placebo group,respectively.Among the drug-treated subjects who achieved remission,the effect of the drug was judged as stable in eight of the 14 subjects as measured by at least two CDAI scores indicating remission in the 15-wk treatment period.A decreased percentage of peripheral natural killer T regulatory cells(a decrease of 28%vs an increase of 16%)and an increased ratio of CD4+/CD8+T lymphocytes(an increase of 11%vs a decrease of9%)were noted in subjects with a significant clinical response.CONCLUSION:Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease. | Eran Israeli Ehud Zigmond Gadi Lalazar Athalia Klein Nilla Hemed Eran Goldin Yaron Ilan | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 2 | Antioxidant therapy for chronic hepatitis C after failure of interferon:Results of phase Ⅱ randomized,double-blind placebo controlled clinical trial显示文摘AIM:TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus(HCV) infection. METHODS:One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo,or oral treatment alone. Primary end points were liver enzymes,HCV-RNA levels and histology. RESULTS:Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo(P= 0.05).Histology activity index(HAI)score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo(P=0.21).HCV-RNA levels decreased by 1-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo(P=NS).In partⅡof the trial,oral administration of antioxidants was not associated with significant alterations in any of the end points. CONCLUSION:Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients. | Ezra Gabbay Ehud Zigmond Orit Pappo Nila Hemed Mina Rowe George Zabrecky Robert Cohen Yaron Ilan | 2007 | World Journal of Gastroenterology2007，13，40： | 2 |
| 3 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor显示文摘 | Anne Brunet Azad Bonni Michael J Zigmond Michael Z Lin Peter Juo Linda S Hu Michael J Anderson Karen C Arden John Blenis Michael E Greenberg | 1999 | Cell1999，，6： | 2 |
| 4 | Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor显示文摘 | Brunet A Bonni A Zigmond MJ | 1999 | Cell1999，96，6： | 1 |
| 5 | The hospital anxiety and depression scale显示文摘 | Zigmond A S Snaith R P | 1983 | Acta Psychiatr Scand1983，67，6： | 1 |
| 6 | Localization of vasoactive intestinal peptide- and peptide histidine isoleucine amide-like immunoreactivities in the rat superior cervical ganglion and its nerve trunks显示文摘 | Sasek CA Zigmond RE | 1989 | J Comp Neurol1989，280，4： | 1 |
| 7 | The hospital anxiety and depression scale显示文摘 | Zigmond AS Snaith RP | 1983 | Acta Psychiatr Scand1983，67，6： | 1 |
| 8 | The hospital anxiety and depresson scale 显示文摘 | Zigmond AS Snaith RP | 1983 | Acta Psychiatr Scand1983，67，6： | 1 |
| 9 | Evidence that some preganglionic sympathetic neurons in the rat contain vasoactive intestinal peptide- or peptide histidine isoleucine amide-like immunoreactivities显示文摘 | Baldwin C Sasek CA Zigmond RE | 1991 | Neuroscience1991，40，1： | 1 |
| 10 | The hospital anxiety and de- pression scale显示文摘 | Zigmond AS Snaith RP | 1983 | Acta Psychiatr Scand1983，67，6： | 1 |
| 11 | The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal secretion for neutrophils 显示文摘 | Showell HJ Freer RJ Zigmond SH | 1976 | J Exp Med1976，143，5： | 1 |
| 12 | The Hospital Anxiety and Depression Scale显示文摘 | Zigmond AS Snaith RP | | 0，，06： | 1 |
| 13 | Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections显示文摘 | Hastings T G Lewis D A Zigmond M J | 1996 | Proc Natl Acad Sci USA1996，93，5： | 1 |
| 14 | The hospital anxiety and depression scale 显示文摘 | Zigmond AS Snaith RP | 1983 | Aeta Psychiatr Stand1983，67，6： | 1 |
| 15 | Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons显示文摘 | Shadiack AM Sun Y Zigmond RE | | 0，，： | 1 |
| 16 | Involvement of leukemia inhibitory factor in the increases in galanin and vasoactive intestinal peptide mRNA and the decreases in neuropeptide Y and tyrosine hydroxylase mRNA in sympathetic neurons after axotomy显示文摘 | Sun Y Zigmond RE | 1996 | J Neurochem1996，67，4： | 1 |
| 17 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor 显示文摘 | BRUNET A BONNI A ZIGMOND MJ | 1999 | Cell (S0092 - 8674)1999，96，： | 1 |
| 18 | Reading inslxuetion and its effects显示文摘 | LEINttARDT G ZIGMOND N COOLEY W | 1981 | American Educational Research Journal1981，18，3： | 1 |
| 19 | The Hospital Anxiety and Depressive Scale显示文摘 | Zigmond AS Snaith RP | 1983 | Acta Psychiatr Scand1983，67，： | 1 |
| 20 | The hospital anxiety and depression scale 显示文摘 | Zigmond AS Snaith RP | 1983 | Acta Psychiatr Scand1983，67，6： | 1 |
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