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| 1 | Wasserstein GAN-Based Small-Sample Augmentation for New-Generation Artificial Intelligence: A Case Study of Cancer-Staging Data in Biology显示文摘It is essential to utilize deep-learning algorithms based on big data for the implementation of the new generation of artificial intelligence. Effective utilization of deep learning relies considerably on the number of labeled samples, which restricts the application of deep learning in an environment with a small sample size. In this paper, we propose an approach based on a generative adversarial network (GAN) combined with a deep neural network (DNN). First, the original samples were divided into a training set and a test set. The GAN was trained with the training set to generate synthetic sample data, which enlarged the training set. Next, the DNN classifier was trained with the synthetic samples. Finally, the classifier was tested with the test set, and the effectiveness of the approach for multi-classification with a small sample size was validated by the indicators. As an empirical case, the approach was then applied to identify the stages of cancers with a small labeled sample size. The experimental results verified that the proposed approach achieved a greater accuracy than traditional methods. This research was an attempt to transform the classical statistical machine-learning classification method based on original samples into a deep-learning classification method based on data augmentation. The use of this approach will contribute to an expansion of application scenarios for the new generation of artificial intelligence based on deep learning, and to an increase in application effectiveness. This research is also expected to contribute to the comprehensive promotion of new-generation artificial intelligence. | Yufei Liu Yuan Zhou Xin Liu Fang Dong Chang Wang Zihong Wang | 2019 | Engineering2019，5，1： | 11 |
| 2 | Long-term treadmill exercise inhibits neuronal cell apoptosis and reduces tau phosphorylation in the cerebral cortex and hippocampus of aged rats显示文摘Aging is an inevitably spontaneous process of the creature.With the increase of age,physical function is degraded in the elderly.One of the most common degradation is memory loss and cognitive impairment in brain function.Neuron loss and neurofibrillary tangles formation contributes to brain dysfunction.Neuron loss is associated with neuronal cell apoptosis.Apoptosis is a process | Guoliang Fang Jiexiu Zhao Pengfei Li Liang Li Tao Yu Xingya Yang Zihong He Ye Tian | 2017 | Science Bulletin2017，62，11： | 7 |
| 3 | Short-term propamocarb exposure induces hepatic metabolism disorder associated with gut microbiota dysbiosis in adult male zebrafish显示文摘Propamocarb (PM) is a pesticide that is widely used to protect cucumbers and other plants from downy mildew.Recently,some studies indicated that PM exposure had potential toxic effects in animals.In this study,adult male zebrafish were exposed to 100 and 1000 μg/l PM for 7 days to assess its effects on metabolism and the gut microbiota.We observed a significant decrease in triglyceride (TG) in the livers of zebrafish that were exposed to 1000 μg/l PM for 7 days.At the same time,some genes related to glycolysis and lipid metabolism in the livers of zebrafish,including hexokinase-1 (HK1),pyruvate kinase (PK),acyi-CoA oxidase (Aco),peroxisome proliferator activated receptor alpha (Ppar-α),apolipoprotein A-Ⅳ-like (Apo),Acetyl CoA carboxylase-1 (Acc1),diacylglycerol acyltransferase (Dgat),and fatty acid synthase (Fas),were also decreased significantly after PM exposure.Based on GC-MS metabolomics analysis,a total of 48 metabolites changed significantly in the 1000 μg/l PM treatment group in comparison with the control group.These altered metabolites were mainly associated with the glycolysis,amino acid metabolism,and lipid metabolism pathways.Interestingly,we further found that the 1000 μg/l PM treatment group also showed significant elevations in Proteobacteria,Bacteroidetes,and Firmicutes at the phylum level.Sequencing of the 16S rRNA gene in the V3-V4 region also showed a significant change in the abundance and diversity of the gut microbiota in the 1000 μg/l PM treatment group.Our results indicated that exposure to PM for a short time could induce hepatic metabolic disorders and gut microbiota dysbiosis in adult male zebrafish. | Rui Zhang Zihong Pan Xiaoyu Wang Manlu Shen Jiajie Zhou Zhengwei Fu Yuanxiang Jin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 6 |
| 4 | Influence of post-heat treatment on the microstructure and mechanical properties of Al-Cu-Mg-Zr alloy manufactured by selective laser melting显示文摘The properties of modified conventional wrought aluminum alloys cannot be significantly enhanced by normal post-heat treatment in that the fine-grained strengthening,arising from high cooling rate in SLM,is underutilized.In this work,compared with the normal T6 heat treatment,a novel simple direct aging regime was proposed to maintain the grain-boundary strengthening and to utilize the precipitation strengthening of secondary AlZr.It was found that a heterogeneous grain structure,which consisted of ultrafine equiaxed(~0.82μm)and columnar(~1.80μm)grains at the bottom and top of molten pool,respectively,was formed in the SLM processed sample.After direct aging(DA),the ultrafine grains were maintained and a mass of spherical coherent L1-AlZr particles with a mean radius of approximately1.15 nm was precipitated.In contrast,after solution treatment and aging(STA),a significant grain coarsening occurred in the equiaxed grain region.Meanwhile,the coarsening L1-AlZr particles,nano-sized S phases and GPB zones were detected in the STA sample.This subsequently induced that the yield strength of the DA sample(~435 MPa)was higher than that of the STA sample(~402 MPa)owing to the grain boundary strengthening and precipitation strengthening.Both the STA and DA samples exhibited a higher strength than that of the other SLMed Al-Cu-Mg series alloys;this was comparable to that of the wrought AA2024-T6 alloy(~393 MPa).Both the STA and DA samples exhibited a higher strength than that of the other SLMed Al-Cu-Mg series alloys;this was comparable to that of the wrought AA2024-T6alloy(~393 MPa). | Yanfang Wang Xin Lin Nan Kang Zihong Wang Yuxi Liu Weidong Huang | 2022 | Journal of Materials Science & Technology2022，，16： | 5 |
| 5 | Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein显示文摘Wutou-Gancao herb-pair is extensively used to attenuate the toxicity and enhance the efficacy of aconite.In this study,potential synergic mechanism of the herb pair was investigated by utilizing multiple ap-proaches.In silico and in vitro Caco-2 cell models were applied to study the potential binding mode of bioactive ingredients existing in liquorice with P-glycoprotein(P-gp),as well as the inhibition effects on P-gp.Additionally,anti-inflammatory activity of aconitine(AC)combined with active ingredients of liquorice,as well as pharmacokinetic patterns of AC after co-administration was investigated.Anti-inflammatory effect of AC(1 mg/kg)in rats was enhanced in combination with bioactive ingredients of liquorice(10 mg/kg).In the meanwhile,the exposure of AC in vivo was altered,in terms of Cmax and AUC.For instance,the Cmax and AUC were increased to 1.9 and 1.3 folds,respectively,when used in combination with liquiritigenin.The in silico study revealed the potential binding mode with outward facing conformation of P-gp.The resulting data obtained from transport of rhodamine-123(Rh-123)across Caco-2 cell monolayer further indicated that the function of P-gp was inhibited by chemicals in liquorice.The synergic effect was therefore proposed to be attributed to inhibition of P-gp by liquorice since AC has been demonstrated to be the substrate of P-gp.The resuls revealed that potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting function of key efflux transporter P-gp to enhance the exposure of AC in systematic circulation,and further the anti-inflammatory effect,which helps clarify the compatibility rationale of these two herbs. | Yufei He Zihong Wei Ying Xie Xiulin Yi Yong Zeng Yazhuo Li Changxiao Liu | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 5 |
| 6 | Preparation of Ce-TiO_2/carbon aerogel electrode and its performance in degradation of 4-chlorophenol显示文摘Ce-TiO_2/CA(carbon aerogel) electrode was prepared by sol impregnation approach. The XRD(X-ray diffraction) and Raman spectra reveal that the TiO2 is anatase. The UV-vis diffuse reflectance spectra show that the optical absorption edge for Ce-TiO_2/CA is red-shifted to 535 nm compared with TiO_2/CA. Under visible light irradiation, the photocurrent density increment on Ce-TiO_2/CA is 75 times that on Ce-TiO_2/FTO(fluorine-doped tin oxide). The electrochemical impedance spectroscopy reveals that the conductivity of CeTiO_2/CA is much better than the Ce-TiO_2/FTO. Furthermore, the Ce-TiO_2/CA can be used to the highest electrosorptive photodegradation for 4-chlorophenol wastewater degradation, which is ascribed predominantly to the efficient reduction of electron-hole pair recombination in the photocatalysts. | Yabo Wang Zihong Pan Dezhi Qin Suzhen Bai Qinlong Peng | 2018 | Journal of Rare Earths2018，36，4： | 4 |
| 7 | Microwave-assisted pyrolysis of vegetable oil soapstock:Comparative study of rapeseed,sunflower,corn,soybean,rice,and peanut oil soapstock显示文摘In this study,the effects of catalytic temperature and the type of soapstock on products from microwave-assisted pyrolysis were investigated.HZSM-5 was used as the catalyst to study the pyrolysis of six different soapstocks at 200℃,300℃,and 400℃ catalytic temperature.Results showed that the bio-oil yields initially increased and then decreased with the increase in catalytic temperature.When the catalytic temperature was 300℃,the bio-oil reached up to the maximum value(65.8 wt.%).Findings indicated that the composition of bio-oil was related to the degree of unsaturation of fatty acids sodium in the soapstocks.In the case of saturated fatty acid sodium,a series of alkanes was formed,whereas the pyrolysis of monounsaturated fatty acid sodium resulted mainly in cycloalkanes,the cycloalkenes obtained from bio-oil was produced by polyunsaturated fatty acid sodium. | Yunpu Wang Shumei Zhang Qiuhao Wu Dengle Duan Yuhuan Liu Roger Ruan Guiming Fu Leilei Dai Lin Jiang Zhenting Yu Zihong Zeng Xiaojie Tian Xiuhua Yang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 8 | Removal of copper by modified chitosan adsorptive membrane显示文摘In this study,a novel adsorptive membrane was prepared from chitosan as the functional polymer and some additive blend solutions by solution casting method.The modified chitosan membrane was characterized by FTIR and its Water Swelling Ratio(WSR).The adsorption of copper ions on the adsorptive membrane was investi-gated in batch experiments.The results obtained from the experiments indicated that the membrane had a good adsorption capacity for copper ions,the optimal ionic strength and pH were 0.1 and 5–6,respectively.Compared with the Langmuir isotherm model,the experimental data were found to be following the Freundlich model. | Xiaoshuai LIU Zihong CHENG Wei MA | 2009 | Frontiers of Chemical Science and Engineering2009，3，1： | 3 |
| 9 | Laser-based directed energy deposition of novel Sc/Zr-modified Al-Mg alloys:columnar-to-equiaxed transition and aging hardening behavior显示文摘The control of grain morphology is important in laser additive manufacturing(LAM),as grain morphology further affects the hot cracking resistance,anisotropy,and strength–ductility synergy of materials.To develop a solidification-control solution and achieve columnar-to-equiaxed transition(CET)in Al-based alloys during LAM,Sc-and-Zr-modified Al-Mg alloys were processed via directed energy deposition(DED).CET was achieved by introducing high potent primary Al_(3)(Sc,Zr)nucleation sites ahead of the solidification interface.Furthermore,the relationship between the solidification control parameters and precipitation behavior of primary Al_(3)(Sc,Zr)nucleation sites was established using the time-dependent nucleation theory.Then,the CET was studied according to the Hunt criterion.The results indicated that coarse columnar grain structure was still obtained at the inner region of the molten pool at low Sc/Zr contents owing to the effective suppression of the precipitation of the primary Al_(3)(Sc,Zr)nucleation sites via rapid solidification during DED.In addition,the relatively low melt temperature at the fusion boundary unavoidably promoted the precipitation of primary Al_(3)(Sc,Zr)nucleation sites,which resulted in a fine equiaxed grains band at the edge of the molten pool.As the Sc/Zr content increased,the solidification cooling rate was not sufficient to suppress the precipitation of the primary Al_(3)(Sc,Zr)nucleation sites,and a fully equiaxed grain structure was obtained.Furthermore,the effect of the layer-by-layer manufacturing process on the subsequent precipitation strengthening of secondary Al_(3)(Sc,Zr)precipitates was discussed.Both the remelting and subsequent aging during thermal cycling should be considered to achieve greater precipitation strengthening. | Zihong Wang Xin Lin Yao Tang Nan Kang Xuehao Gao Shuoqing Shi Weidong Huang | 2021 | Journal of Materials Science & Technology2021，，10： | 3 |
| 10 | Phloroglucinol derivative compound 21 attenuates cuprizoneinduced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation显示文摘Multiple sclerosis(MS) is a chronic autoimmune demyelinating disease in the central nervous system. The myelin loss is mainly caused by dysfunction of oligodendrocytes and inflammatory responses of microglia and astrocytes further aggravate the demyelination. Current therapies for MS focus on suppressing the overactivated immune response but cannot halt the disease progress, so effective drugs are urgently needed. Compound 21 is a phloroglucinol derivative that has been proved to have an outstanding anti-inflammatory effect. The purpose of the present study is to investigate whether this novel compound is effective in MS. The cuprizone-induced model was used in this study to mimic the pathological progress of MS. The results showed that Compound 21 significantly improved the neurological dysfunction and motor coordination impairment. Luxol Fast Blue staining and myelin basic protein immunostaining demonstrated that Compound 21 remarkably promoted remyelination. In addition,Compound 21 significantly promoted oligodendrocytes differentiation. Furthermore, we found that Compound 21 decreased microglia and astrocytes activities and the subsequent neuroinflammatory response, indicating that the anti-inflammatory effect of Compound 21 was also involved in its neuro-protection. All the data prove that Compound 21 exerts protective effect on MS through promoting remyelination and suppressing neuroinflammation, indicating that Compound 21 might be a potential drug candidate for MS treatment. | Zhe Zhao Xiu-qi Bao Zihong Zhang Hui Liu Dan Zhang | 2020 | Science China(Life Sciences)2020，63，6： | 3 |
| 11 | Cluster based node scheduling method for wireless sensor networks显示文摘By researching on the node scheduling problem of m-covered and connected sensor networks,a new concept of two-hops-cluster is proposed in this paper,and based on it,a new distributed node scheduling algorithm THCNS for allocating all nodes in the sensor network into k(k≤m) different groups {0,1,...,k 1} is designed,without requiring location information.Our algorithm guarantees that each group to be connected and maintains the coverage ratio with high possibility.Theoretical analysis and simulation results show that it has better performance than previous randomized scheduling scheme,and can prolong the lifetime of the sensor network effectively. | WANG Lei WEI RuiZhong TIAN ZiHong | 2012 | Science China(Information Sciences)2012，55，4： | 2 |
| 12 | Evolutionary biogeography on Ophiocordyceps sinensis:An indicator of molecular phylogeny to geochronological and ecological exchanges显示文摘The fungus Ophiocordyceps sinensis is endemic to the vast region of the Qinghai-Tibetan plateau(QTP).The unique and complex geographical environmental conditions have led to the 'sky island' distribution structure of O.sinensis.Due to limited and unbalanced sample collections,the previous data on O.sinensis regarding its genetic diversity and spatial structure have been deemed insufficient.In this study,we analyzed the diversity and phylogeographic structures of O.sinensis using internally transcribed spacer region(ITS) and 5-locus datasets by a large-scale sampling.A total of 111 haplotypes of ITS sequences were identified from 948 samples data of the fungus O.sinensis,with representing high genetic diversity,and 8 phylogenetic clades were recognized in O.sinensis.Both the southeastern Tibet and the northwestern Yunnan were the centers of genetic diversity and genetic differentiation of the fungus,and they were inferred as the glacial refugia in the Quaternary.Three distribution patterns were identified to correspond to the 8 clades,including but not limited to the coexistence of widely and specific local distributive structures.It also revealed that the differentiation pattern of O.sinensis did not fit for the isolation-by-distance model.The differentiation into the 8 clades occurred between 1.56 Myr and6.62 Myr.The ancestor of O.sinensis most likely originated in the late Miocene(6.62 Myr) in the northwestern Yunnan,and the Scene A-C of the Qinghai-Tibetan movements may have played an important role in the differentiation of O.sinensis during the late Miocene-Pliocene periods.Our current results provide a much clearer and detailed understanding of the genetic diversity and geographical spatial distribution of the endemic alpine fungus O.sinensis.It also revealed that the geochronology resulting from paleogeology could be cross-examined with biomolecular clock at a finer scale. | Yongdong Dai Changkui Wu Feng Yuan Yuanbing Wang Luodong Huang Zihong Chen Wenbo Zeng Yao Wang Zhuliang Yang Pusheng Zeng Paul Lemetti Xuanxue Mo Hong Yu | 2020 | Geoscience Frontiers2020，11，3： | 2 |
| 13 | Laser powder bed fusion of high-strength Sc/Zr-modified Al–Mg alloy:phase selection,microstructural/mechanical heterogeneity,and tensile deformation behavior显示文摘Laser powder bed fusion(L-PBF)of Sc/Zr-modified Al-based alloys has recently become a promising method for developing a new generation of high-performance Al alloys.To clarify the modification roles of Sc/Zr elements,an Al–4.66Mg–0.48Mn–0.72Sc–0.33Zr(wt.%)alloy was processed using L-PBF.The effect of the local solidification condition of the molten pool on the precipitation behavior of primary Al_(3)(Sc,Zr)was analyzed based on time-dependent nucleation theory.It was found that primary Al_(3)(Sc,Zr)inevitably precipitated at the fusion boundary,while its precipitation could be effectively suppressed in the inner region of the molten pool.This subsequently induced the formation of a heterogeneousα-Al matrix.After direct aging,the heredity of solidification microstructure introduced heterogeneous secondary Al_(3)(Sc,Zr)precipitates withinα-Al matrix.Owing to the inverse relationship between grain boundary strengthening and precipitation strengthening,the direct-aged sample with dual heterogeneous structures exhibited reduced mechanical heterogeneity,resulting in lowered hetero-deformation-induced hardening.The low strain-hardening capability in the direct-aged sample promoted necking instability while inducing a large Lüders elongation,which effectively improved the tensile ductility. | Zihong Wang Xin Lin Nan Kang Jing Chen Hua Tan Zhe Feng Zehao Qin Haiou Yang Weidong Huang | 2021 | Journal of Materials Science & Technology2021，，36： | 2 |
| 14 | Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis显示文摘 | Xiaobing Chen Yongsheng Wang Hongping Xia Qiwu Wang Xiaochun Jiang Zihong Lin Yuedong Ma Yang Yang Minghua Hu | 2012 | Molecular Biology Reports2012，，： | 2 |
| 15 | K2,3+e-design of λKv显示文摘 | Tian Zihong Kang Qingde | 2002 | Journal of Hebei Normal University2002，26，： | 2 |
| 16 | Characterization of Bimetallic Ru-Sn Supported Catalysts and Hydrogenation of 1,4-Cyclohexanedicarboxylic Acid 显示文摘 | Zhu Zhiqing Lu Zihong Li Bin | 2006 | Appl Catal A2006，302，2： | 1 |
| 17 | Electrochemical immunoassay of benzopyrene based on dual amplification strategy of electron-accelerated Fe 3 O 4 /polyaniline platform and multi-enzyme-functionalized carbon sphere label显示文摘 | Mouhong Lin Yingju Liu Zihong Sun Shenglai Zhang Zhuohong Yang Chunlin Ni | 2012 | Analytica Chimica Acta2012，，： | 1 |
| 18 | Regional stress field around the Taigu fault zone in Shanxi Province,China显示文摘A comprehensive study on regional stress field around the Taigu fault zone in Shanxi Province,China,was performed in this study.To get a better understanding of the present-day stress status in this area,31 focal mechanisms of M_L≥3 earthquakes since 1965 were compiled,and the best stress tensor was then inverted based on the database.Additionally,magnetic fabrics along the Taigu fault zone were investigated to get an indication of the regional stress field in the past.Our results show that the present-day stress field around the Taigu fault zone is characterized by astable NW-SE extension with a strikeslip component,consistent with the geological surveys and recent GPS data.Results from magnetic fabrics indicate that the orientations of principal stress axes from magnetic fabrics of sedimentary rocks in Neogene coincide to the orientations of principal stress axes from focal mechanisms.The south segment of the Taigu fault displays more complicated magnetic fabrics and more activity of moderate earthquakes.It is connected with the Mianshan west fault and intersects with NW-SE striking Fenyang fault and the north fault of the Lingshi uplift at the south edge of Taiyuan basin.This may be the area needing more attention in terms of seismic risk along the Taigu fault. | Bin Li Zihong Li Mathilde B.S?rensen Reidar L?vlie Liqiang Liu Kuvvet Atakan | 2015 | Earthquake Science2015，28，5： | 1 |
| 19 | Synthesis and properties of 1,3,4-oxadiazole-containing high-proformace bismaleimide resins显示文摘 | Tang Haoyu Naiheng Song Zihong Gao | 2007 | Polymer2007，48，： | 1 |
| 20 | Analysis and thinking of students majoring in Educational Technology 显示文摘 | Miaomiao Hu Zihong Liu Zhichao Zhao | 2006 | Modem Educational Technology2006，，4： | 1 |
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