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| 1 | Morphological evolution of γ'precipitates in a nickel-based superalloy during various solution treatments显示文摘The morphological evolution of the γ' phase in nickel-based superalloy жc6y during various solution heat treatments was investigated. The significant changes of the γ' precipitates were observed in the solution-treated samples. The coarsening and dissolution of γ' phase simulta-neously occurred at intermediate temperatures. In some areas, the primary precipitates became blunt and the adjacent ones were intercon-nected with each other via a diffuse neck, indicating a coarsening process of the primary γ' population. The coarsening was dominated by the precipitate agglomeration mechanism (PAM) rather than by the well-known Ostwald ripening mechanism. In other areas, the partial dissolu-tion of the γ' precipitates began to occur, spreading gradually from dendrite cores to interdendritic regions. In addition, a flower-like γ' struc-ture was developed during the subsolvus solution treatments. The observable long filaments composed of erraticly shaped precipitates were caused by the heterogeneous nucleation of the cooling precipitates during water quenching. | Zhou, Yu Zhang, Zheng Zhao, Zihua Zhong, Qunpeng | 2012 | Rare Metals2012，31，3： | 10 |
| 2 | 淀粉结构及应用显示文摘 | Dong-soon Suh Zihua Ao Jay-lin Jane 黄继红 | 2005 | 广西轻工业2005，21，4： | 9 |
| 3 | Features of a rare advection-radiation fog event显示文摘To investigate effects of atmospheric pollutants on fog nature, a comprehensive in situ observation project was implemented in the northern suburb of Nanjing, in December of 2006. For December 24-27 there occurred a heavy fog lasting 4 d in succession. This event is of rare characteristics, namely long persistence, high concentration, tall fog top, acid fog water and explosive growth. Detailed analysis along with the causes of the fog was presented. The evidence suggests that the fog was generated by nighttime radiative cooling, maintained and developed under effects of warm, wet advection. As a result, it is an advection-radiation fog event. | PU MeiJuan ZHANG GuoZheng YAN WenLian LI ZiHua | 2008 | Science China Earth Sciences2008，51，7： | 8 |
| 4 | Cascade effects of crop species richness on the diversity of pest insects and their natural enemies显示文摘Understanding how plant species richness influences the diversity of herbivorous and predatory/parasitic arthropods is central to community ecology.We explore the effects of crop species richness on the diversity of pest insects and their natural enemies.Using data from a four-year experiment with five levels of crop species richness,we found that crop species richness significantly affected the pest species richness,but there were no significant effects on richness of the pests’natural enemies.In contrast,the species richness of pest insects significantly affected their natural enemies.These findings suggest a cascade effect where trophic interactions are strong between adjacent trophic levels,while the interactions between connected but nonadjacent trophic levels are weakened by the intermediate trophic level.High crop species richness resulted in a more stable arthropod community compared with communities in monoculture crops.Our results highlight the complicated cross-trophic interactions and the crucial role of crop diversity in the food webs of agro-ecosystems. | SHI PeiJian HUI Cang MEN XingYuan ZHAO ZiHua OUYANG Fang GE Feng JIN XianShi CAO HaiFeng LI B.Larry | 2014 | Science China(Life Sciences)2014，57，7： | 6 |
| 5 | High-resolution carbon isotope record for the Paleocene-Eocene thermal maximum from the Nanyang Basin,Central China显示文摘古新始新世的热最大值(PETM ) 是全球温暖的一个短暂事件,与发生在古新 / 始新世的边界的巨大的大气的温室气体输入联系了。Biostratigraphic 和同位素 stratigraphic 研究显示 PETM 事件很好在 Nanyang 盆在 Yuhuangding 节的泥土存款被记录,华中,与碳同位素,在 19-m-thick 泥土以内的锝 ?.1 鈥 ? 的否定旅行扔。这是到目前为止在世界上发现的 PETM 的最高的分辨率记录。PETM 事件在 2-cm-thick 泥土沉积以内被触发,与未 1 3C (稳定的碳同位素比率) 从的减少 ? 3.2 鈥 ? 到 ? 5.2 鈥吗?为是的一个短暂时期建议一个巨大的甲烷水合物版本可能由一个灾难的事件引起了。在海洋、陆上的记录之间的比较为 PETM 事件显示鈥淭h ree 阶段模型鈥 ? 。开始在未 1 3C 记录有一次快速的否定旅行,由一个慢慢地减少的趋势,然后渐渐的积极恢复列在后面,相应分别地到海洋的甲烷水合物的快速的分离,由甲烷然后释放甲烷的消费的一个慢版本列在后面。 | ZHU Min DINGZhongLi WANG Xu CHEN ZuoLing JIANG HanChao DONG XinXin JI JunLiang TANG ZiHua LUO Pan | 2010 | Chinese Science Bulletin2010，55，31： | 6 |
| 6 | An Analytical Method for Calculating the Shielding Effectiveness of an Enclosure with an Oblique Rectangular Aperture显示文摘An efficient analytical method is proposed to calculate the Shielding effectiveness(SE)of an enclosure with an oblique rectangular aperture.This enclosure was first decomposed into two ones with horizontal rectangular apertures through mirror image and Green function theories.The SE of each decomposed enclosure was calculated by the Robinson’s method.The relationship between the SE of the original cavity and those of the decomposed ones was also derived analytically.The SE of the original cavity could be directly obtained from this analytical relationship.The accuracy of the proposed method was validated with measurements and the Transmission line matrix(TLM)solver.The results show that the efficiency was largely improved compared with the TLM solver. | SU Donglin LIU Hongyi YANG Shunchuan ZHAO Zihua SUI Donghai | 2019 | Chinese Journal of Electronics2019，28，4： | 5 |
| 7 | Study on the performance of TEG with heat transfer enhancement using graphene-water nanofluid for a TEG cooling system显示文摘Improvement of the heat transfer effect of cold side of a thermoelectric generator(TEG) is one of the approaches to enhance the performance of the TEG systems.As a new type of heat transfer media,nanofluids can enhance the heat transfer performance of working liquid significantly.In this study,the performance of a commercial TEG with graphene-water(GW) nanofluid as coolants in a minichannel heat exchanger is investigated experimentally at low temperatures.The results show that the output power of TEG increases with the flow rate under 950 mL/min.However,the fluid flow rate has no influence on the output power of TEG with higher flow rate(larger than 950 mL/min) when the heat transfer dynamic balance state of the system is reached.The optimal concentration and flow rate of nanofluid are 0.1 wt%and 950 mL/min,respectively.At the optimal conditions,the improved voltage,output power and conversion efficiency with GW nanofluid applied in the cooling system are increased by11.29%,21.55%and 3.5%in comparison with those with only water applied,respectively. | LI YiHuai WU ZiHua XIE HuaQing XING JiaoJiao MAO JianHui WANG Yuan Yuan LI Zhen | 2017 | Science China(Technological Sciences)2017，60，8： | 5 |
| 8 | Suppressed oxygen extraction and degradation of LiNixMnyCo2O2 cathodes at high charge cut-off voltages显示文摘 | Jianming Zheng Pengfei Yan Jiandong Zhang Mark H. Engelhard Zihua Zhu Bryant J. Polzin Steve Trask Jie Xiao Chongmin Wang Jiguang Zhang | 2017 | Nano Research2017，10，12： | 5 |
| 9 | Landscape changes have greater effects than climate changes on six insect pests in China显示文摘In recent years, global changes are the major causes of frequent, widespread outbreaks of pests in mosaic landscapes, which have received substantial attention worldwide. We collected data on global changes(landscape and climate) and economic damage caused by six main insect pests during 1951–2010 in China. Landscape changes had significant effects on all six insect pests. Pest damage increased significantly with increasing arable land area in agricultural landscapes. However, climate changes had no effect on damage caused by pests, except for the rice leaf roller(Cnaphalocrocis medinalis Guenee) and armyworm(Mythimna separate(Walker)), which caused less damage to crops with increasing mean temperature. Our results indicate that there is slight evidence of possible offset effects of climate changes on the increasing damage from these two agricultural pests. Landscape changes have caused serious outbreaks of several species, which suggests the possibility of the use of landscape design for the control of pest populations through habitat rearrangement. Landscape manipulation may be used as a green method to achieve sustainable pest management with minimal use of insecticides and herbicides. | Zihua Zhao Hardev S Sandhu Fang Ouyang Feng Ge | 2016 | Science China(Life Sciences)2016，59，6： | 5 |
| 10 | Agonistic AT_1 Receptor Autoantibody Increases in Serum of Patients with Refractory Hypertension and Improves Ca^(2+) Mobilization in Cultured Rat Vascular Smooth Muscle Cells显示文摘Agonistic AT1 receptor autoantibodies (AT1-AAs) have been described in the patients with malignant hypertension or preeclampia. Furthermore, AT1-AAs were highly associated with refractory hypertension. Function of vascular smooth muscle cells (VSMCs) is important in the regulation of blood pressure. We investigated and compared the ability of angiotensin II (Ang II) and AT1-AAs to stimulate the intracellular calcium mobilization and cellular proliferation of rat VSMCs. Twenty-two patients with refractory hypertension, 24 patients with non-refractory hypertension and 37 normotensives were recruited. The serum of each patient was detected for the presence of AT1-AAs by ELISA. Ang II and the AT1-AAs from the sera of patients were used to stimulate rat VSMCs in vitro. AT1-AAs were detected in 10/22, 3/24 and 3/37 of patients with refractory hypertension, non-refractory hypertension and normotensives, respectively. AT1-AAs led the increase intracellular calcium mobilization in a dose-dependent manner and cellular proliferation of VSMCs just as Ang II. Both of these effects caused by AT1-AAs were blocked with losartan or a peptide corresponding to a part of the second extracellular loop of AT1 receptor. Since AT1-AAs exhibited pharmacological activity in rat VSMCs just as Ang II, they might play a role in the elevation of peripheral vascular resistance and in vascular remodeling. And AT1-AAs were suggested to involve in resistance to antihypertensive therapy. | Feng Zhu Yanxiang Sun Yuhua Liao Yumiao Wei Ming Chen Min Wang Zihua Zhou | 2008 | Cellular & Molecular Immunology2008，5，3： | 4 |
| 11 | An adaptive scaled boundary finite element method by subdividing subdomains for elastodynamic problems显示文摘The scaled boundary finite element method(SBFEM) is a semi-analytical numerical method,which models an analysis domain by a small number of large-sized subdomains and discretises subdomain boundaries only.In a subdomain,all fields of state variables including displacement,stress,velocity and acceleration are semi-analytical,and the kinetic energy,strain energy and energy error are all integrated semi-analytically.These advantages are taken in this study to develop a posteriori h-hierarchical adaptive SBFEM for transient elastodynamic problems using a mesh refinement procedure which subdivides subdomains.Because only a small number of subdomains are subdivided,mesh refinement is very simple and efficient,and mesh mapping to transfer state variables from an old mesh to a new one is also very simple but accurate.Two 2D examples with stress wave propagation were modelled.The results show that the developed method is capable of capturing propagation of steep stress regions and calculating accurate dynamic responses,using only a fraction of degrees of freedom required by adaptive finite element method. | ZHANG ZiHua 1,2,YANG ZhenJun 2,LIU GuoHua 1 & HU YunJin 1 1 College of Civil Engineering and Architecture,Zhejiang University,Hangzhou 310058,China 2 School of Engineering,University of Liverpool,L69 3GQ,UK | 2011 | Science China(Technological Sciences)2011，54，S1： | 4 |
| 12 | Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration signals显示文摘A novel damage assessment method based on the decay ratio of acceleration signals(DRAS)was proposed.Two experimental tests were used to show the efficiency.Three beams were gradually damaged,and then the changes of dynamic parameters were monitored from initial to failure state.In addition,a new method was compared with the linear modal-based damage assessment using wavelet transform(WT).The results clearly show that DRAS increases in linear elasticity state and microcrack propagation state,while DRAS decreases in macrocrack propagation state.Preliminary analysis was developed considering the beat phenomenon in the nonlinear state to explain the turn point of DRAS.With better sensibility of damage than modal parameters,probably DRAS is a promising damage indicator in damage assessment. | Zhigen WU Guohua LIU Zihua ZHANG | 2011 | Frontiers of Structural and Civil Engineering2011，5，1： | 3 |
| 13 | Solute redistribution and micromechanical properties of rapidly solidified multicomponent Ni-based alloys显示文摘The solute trapping effect and microhardness enhancement of quaternary Ni-5%Cu-5%Ag-5%Sn and quinary Ni-5%Cu-5%Ag-5%Sn-5%Ge alloys during rapid dendritic solidification are investigated by glass fluxing technique. In these two alloys, the experimental maximum undercoolings of 310 K(0.18 T_L) and 220 K(0.13 T_L) have been achieved and the rapidly solidified microstructures are composed of α(Ni) and(Ag) solid solution phases. The morphological transition from coarse dendrite into equiaxed structure is observed for α(Ni) phase with the increase of undercooling. The dendritic growth velocity of α(Ni) phase in quaternary Ni-5%Cu-5%Ag-5%Sn alloy is larger than that in quinary Ni-5%Cu-5%Ag-5%Sn-5%Ge alloy, which increases firstly and then decreases with the enhancement of bulk undercooling. The Vickers hardness of α(Ni) phase in these two alloys is enhanced with the increase of undercooling, which is attributed mainly to the grain refinement effect. Meanwhile, the solute trapping effect of Cu, Sn and Ge elements in the α(Ni) phase also contributes to the microhardness enhancement under large undercoolings. The addition of Ge element effectively increases the microhardness of α(Ni) phase due to solute strengthening mechanism. | YAN Na WANG ZiHua RUAN Ying WEI BingBo | 2019 | Science China(Technological Sciences)2019，62，3： | 2 |
| 14 | Regulation of DNA double-strand break repair pathway choice:a new focus on 53BP1显示文摘Maintenance of cellular homeostasis and genome integrity is a critical responsibility of DNA double-strand break(DSB)signaling.P53-binding protein 1(53BP1)plays a critical role in coordinating the DSB repair pathway choice and promotes the non-homologous end-joining(NHEJ)-mediated DSB repair pathway that rejoins DSB ends.New insights have been gained into a basic molecular mechanism that is involved in 53BP1 recruitment to the DNA lesion and how 53BP1 then recruits the DNA break-responsive effectors that promote NHEJ-mediated DSB repair while inhibiting homologous recombination(HR)signaling.This review focuses on the up-and downstream pathways of 53BP1 and how 53BP1 promotes NHEJ-mediated DSB repair,which in turn promotes the sensitivity of poly(ADP-ribose)polymerase inhibitor(PARPi)in BRCA1-deficient cancers and consequently provides an avenue for improving cancer therapy strategies. | Fan ZHANG Zihua GONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，1： | 2 |
| 15 | Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip显示文摘EGFR mutations companion diagnostics have been proved to be crucial for the efficacy of tyrosine kinase inhibitor targeted cancer therapies. To uncover multiple mutations occurred in minority of EGFR-mutated cells,which may be covered by the noises from majority of unmutated cells, is currently becoming an urgent clinical requirement. Here we present the validation of a microfluidic-chip-based method for detecting EGFR multimutations at single-cell level. By trapping and immunofluorescently imaging single cells in specifically designed silicon microwells, the EGFR-expressed cellswere easily identified. By in situ lysing single cells, the cell lysates of EGFR-expressed cells were retrieved without cross-contamination. Benefited from excluding the noise from cells without EGFR expression, the simple and cost-effective Sanger's sequencing, but not the expensive deep sequencing of the whole cell population, was used to discover multi-mutations. We verified the new method with precisely discovering three most important EGFR drugrelated mutations from a sample in which EGFR-mutated cells only account for a small percentage of whole cell population. The microfluidic chip is capable of discovering not only the existence of specific EGFR multi-mutations,but also other valuable single-cell-level information: on which specific cells the mutations occurred, or whether different mutations coexist on the same cells. This microfluidic chip constitutes a promising method to promote simple and cost-effective Sanger's sequencing to be a routine test before performing targeted cancer therapy. | Ren Li Mingxing Zhou Jine Li Zihua Wang Weikai Zhang Chunyan Yue Yan Ma Hailin Peng Zewen Wei Zhiyuan Hu | 2018 | Nano-Micro Letters2018，10，1： | 2 |
| 16 | Study on the interfacial shear behavior of steel reinforced concrete (SRC) members with stud connectors after fire显示文摘在在周围的温度下面的火和二 SRCSC 被执行以后,静态地, 20 钢的推外面测试在形状钢的表面上与饰钉接头增强了具体的短柱(SRCSC ) ,以便学习失败模式,装载滑倒关系并且界面砍在火以后的 SRC 成员的转移。试验性的结果证明典型失败模式和在火以后的 SRCSC 的装载滑倒曲线几乎与在周围的温度下面的盒子一样。界面砍 SRCSC 的转移不仅随标本经历了的山峰温度的增加而且随山峰温度持续时间的增加指数地衰退。界面砍与在钢网安排的饰钉一起的标本的转移比那些高得多,饰钉安排在钢凸缘。SRCSC 的实验公式界面砍在火以后的转移被建议,并且计算结果通常与试验性的结果同意很好。 | Zihua ZHANG Junhua LI Lei ZHANG Kai YU | 2014 | Frontiers of Structural and Civil Engineering2014，8，2： | 2 |
| 17 | The effect of slow shot speed and casting pressure on the 3D microstructure of high pressure die casting AE44 magnesium alloy显示文摘3D reconstruction and 2D observation were conducted to characterize the microstructure of the castings produced through high pressure die casting with different parameters.Our results indicate that shrinkage pores generally co-existed with externally solidified crystals(ESCs).In specimen produced without fast slow shot speed,big net-shrinkage pores accompanied with ESCs were found in the center of the specimen.When the casting pressurization was introduced,the shrinkage pores gathered to the specimen center and became much less due to the optimization of melt feeding.Much more porosity was found near the gate rather than in the middle of the rod bar,especially gas pores.Thefilling process simulation reveals that the middle position of the bars wasfirstlyfilled and followed by the near gate position accompanied with one intense turbulentflow. | Chaosheng Ma Wenbo YU Tongtong Zhang Zihua Zhang Yihu Ma Shoumei Xiong | 2023 | Journal of Magnesium and Alloys2023，11，2： | 2 |
| 18 | A Clinicopathological Study on the Expression of Cadherin-17 and Caudal-related Homeobox Transcription Factor (CDX2) in Human Gastric Carcinoma显示文摘 | Jie Ge Zhikang Chen Shaobin Wu Weijie Yuan Bin Hu Zihua Chen | 2008 | Clinical Oncology2008，，4： | 2 |
| 19 | Downregulation of thioredoxin reductase 1 expression in the substantia nigra pars compacta of Parkinson's disease mice显示文摘Because neurons are susceptible to oxidative damage and thioredoxin reductase 1 is extensively distributed in the central nervous system and has antioxidant properties,we speculated that the enzyme may be involved in the pathogenesis of Parkinson’s disease.A Parkinson’s disease model was produced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into C57BL/6 mice.Real-time reverse transcription-PCR,western blot analysis and colorimetric assay showed that the levels of thioredoxin reductase 1 mRNA and protein were decreased,along with a significant reduction in thioredoxin reductase activity,in the midbrain of Parkinson’s disease mice compared with normal mice.Immunohistochemical staining revealed that the number of thioredoxin reductase 1-positive neurons in the substantia nigra pars compacta of Parkinson’s disease mice was significantly decreased compared with normal mice.These experimental findings suggest that the expression of thioredoxin reductase 1 in the substantia nigra pars compacta of Parkinson’s disease mice is significantly decreased,and that the enzyme may be associated with disease onset. | Zihua Liu Yuhong Jing Jie Yin Jiying Mu Tingting Yao Liping Gao | 2013 | Neural Regeneration Research2013，8，35： | 2 |
| 20 | Overexpression of EphA2 correlates with epithelial–mesenchymal transition-related proteins in gastric cancer and their prognostic importance for postoperative patients显示文摘 | Futao Hou Weijie Yuan Jin Huang Liyuan Qian Zhikang Chen Jie Ge Shaobin Wu Jinxiang Chen Jixu Wang Zihua Chen | 2012 | Medical Oncology2012，，4： | 2 |
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