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97篇 您的检索式:作者名="Zimmer V"
    题名 作者 年代 出处 被引量
1厚壁奥氏体焊缝超声波检测之探究(英文)显示文摘由于奥氏体焊缝中材料性能的各向异性和微观组织结构的不同,奥氏体焊缝的超声波检测是非常困难的。超声波在奥氏体焊缝中会沿金属结晶方向发生偏转,并在焊缝边界上发生散射。过去十年来,人们开发了多种模拟各向异性材料中声波传播的仿真工具。本文则以常规超声波检测方法为基础,将声线跟踪法和弹性动力学有限积分技术(EFIT)相结合,应用于含晶间应力腐蚀裂纹的厚壁奥氏体焊缝中,其结果显示声线跟踪法和弹性动力学有限积分技术(EFIT)结合应用,有助于超声波检测参数的选取。Han T Y Khler B Schmitz V Zimmer A Langenberg K J 2009无损检测2009,31,11:3
2miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 2018神经损伤与功能重建2018,13,12:3
3A convenient synthesis of 3-alkythiophenes显示文摘Pham C V Mark H B Zimmer H 1986Synthetic Communication1986,16,6:1
4A convenient synthesis of 3-alkylthiophenes显示文摘Pham C V Mark H B Zimmer H 1986Synthetic Communications1986,16,6:1
5IFN-alpha-induced signal transduction,gene expression,and antitumor activity of immune effector cells are negatively regulated by suppressor of cytokine signaling proteins显示文摘Zimmerer J M Lesinski G B Kondadasula S V 2007J Immunol2007,178,8:1
6Variant adiponu-trin(PNPLA3)represents a common fibrosis risk gene:non-invasive elastography-based study in chronic liver disease显示文摘Krawczyk M Grünhage F Zimmer V 2011J Hepatology2011,55,2:1
7In-duction of cachexia in mice by systemically adminis-tered myostatin显示文摘Zimmers T A Davies M V Koniaris L G 2002Science2002,296,5572:1
8A convenient synthesis of 3-alkylthiophenes显示文摘 Mark H B Zimmer H 1986Synthetic Communications1986,16,6:1
9Optical and luminescent properties of anisotropic tractate crystals显示文摘Kolobanov V N Kamenskikh I A Mikhailin V V Shpinkov I N Spessky D A Zadneprovsky B I Potkin L I Zimmerer G 2002Nuclear Instruments and Methods in Physics Research A2002,486,:1
10The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity显示文摘Von Messling V Zimmer G Herrler G 2001Virol2001,75,14:1
11The hemagglutinin of ca-nine distemper virus determines tropism and cytopathogenicity显示文摘von Messling V Zimmer G Herrler G 2001Journal of Virology2001,75,14:1
12A convenient synthesis of 3-alkylthiophenes 显示文摘 Mark H B Zimmer H 1986Synthetic Communications1986,16,6:1
13The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity显示文摘VERONIKA V M ZIMMER G HERRLER G 2001J Virol2001,75,14:1
14Phase Ⅰ / Ⅱ trial of combined ^131I anti-CEA monoclonal antibody and hyperthermia in patients with advanced colorectal adenocarcinoma显示文摘Mittal B B Zimmer MA Sathiaseelan V 1996GrochCancer1996,78,9:1
15The hemaggluti-nin of canine distemper virus determines tropism and cyto- pathogenicity显示文摘yon Messling V Zimmer G Herrler G 2001J Virol2001,75,14:1
16Albumin kinetics in hypoalbuminemic patients receiving total parenteral nutrition显示文摘Spiess A Mikalunas V Zimmer M 1996JPEN J Parenter Enteral Nutr1996,20,6:1
17Mouse heart Na+ channels:primary structure and function of two isoforms and alternatively spliced variants显示文摘Zimmer T Bollensdorff C Haufe V 2002Am J Physiol Heart Circ Physiol2002,282,3:1
18The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity显示文摘VON MESSLING V ZIMMER G HERRLER G 2001J Virol2001,75,14:1
19Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiationfactor 4E显示文摘RINKER-SCHAEFFER C W AUSTIN V ZIMMER S 1992J Biol Chem1992,267,10:1
20A simple,versatile,sensitive and volume-independent method for quantitative protein determination which is independent of other external influences显示文摘Neuhoff V Philipp K Zimmer HG 1979Physiol Chem1979,360,:1
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