|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Use of DNA barcodes to identify flowering plants 显示文摘 | Kress W J Wurdack K J Zimmer E A | 2005 | Proceedings of the National Academy of Sciences USA2005，102，： | 1 |
| 3 | Gonadotropinreleasing hormone agonist (GnRH-α) therapy alters activity of plasminogen activators,matrix metalloproteinases and their inhibitors in rat models for adhesion formation and endometriosis:potential GnRH-α-regulated mechanisms reducing adhesion formation显示文摘 | Sharpe-Timms K L Zimmer R L Jolliff W J | 1998 | Fertil Steril1998，69，5： | 1 |
| 4 | Molybdenum metabolism in plants显示文摘 | Zimmer W Mendel R | 1999 | Plant Biology1999，1，2： | 1 |
| 5 | Use of DNA barcodes to identify flowering plants 显示文摘 | KRESS W J WURDACK K J ZIMMER E A | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，23： | 1 |
| 6 | Use of DNA barcodes to identify flowering plants 显示文摘 | Kress W J Wurdeck K J Zimmer E A | 2005 | PNAS2005，102，23： | 1 |
| 7 | Physiological and melocular biological characterization of ammonia oxidation of the heterotrophic nitrifier pseudomonas putida显示文摘 | Daum M Zimmer W Papen H | 1998 | Curr Microbiol1998，37，： | 1 |
| 8 | Physiological and molecular biological characterization of ammonia oxidation of the heterotrophic nitrifier Pseudomonas putida显示文摘 | DAUM M ZIMMER W PAPEN H | 1998 | Current Mi- crobiology1998，37，4： | 1 |
| 9 | Gonadotropin-releasing hormone agonist (GnRH-a) therapy alters activity of plasminogen activators, matrix metalloproteinases and their inhibitors in rat models for adhesion formation and endometriosis: potential GnRH-a-regulated mechanisms reducing adhesion formation显示文摘 | Sharpe-Timms KL Zimmer RL Jolliliff W J | 1998 | Fertility and Sterility1998，69，5： | 1 |
| 10 | Characterization of Boron-doped Micro-and Nanocrystalline Diamond Films Deposited by Wafer-scale Hot Filament Chemical Vapor Deposition for MEMS Applications显示文摘 | Zhang J C Zimmer J W Howe R T | 2008 | Diamond & Related Materials2008，17，1： | 1 |
| 11 | Cell-specific nuclear import of plasmid DNA显示文摘 | Vacik J Dean B S Zimmer W E | 1999 | Gene Ther1999，6，6： | 1 |
| 12 | The role of arthroscopy in the assessment and treatment of tibial plateau fractures显示文摘 | Fowble CD Zimmer J W Schepsis AA | 1993 | Arthroscopy1993，9，： | 1 |
| 13 | Detection and prognosis of recurrent gastric cancer is routine follow up gastrectomy worthwhile显示文摘 | Bohner H Zimmer T Hofenmiller W | 2000 | Hepato Gastroenerology2000，47，35： | 1 |
| 14 | Detection and prognosis of recurrent gastric Cancer-is routine follow-up after gastrectomy worthwhile显示文摘 | Bohner H Zimmer T Hopfenmialler W | 2000 | Hepato Gastroenterology2000，47，35： | 1 |
| 15 | Nickel impregnated silicalite-1 as an electro catalyst for methanol oxidation显示文摘 | Khalil M W Abdel Rahim M A Zimmer A | 2005 | J Power Sources2005，144，： | 1 |
| 16 | Use of DNA barcodesto identify flowering plants 显示文摘 | Kress W J Wurdaek K J Zimmer E A | 2005 | PNAS2005，102，23： | 1 |
| 17 | The Role of Arthroscopy in the Assessment and Treatment of Tibial Plateau Fractures显示文摘 | Fowble C D Zimmer J W Schepsis A A | 1993 | Arthroscopy1993，9，5： | 1 |
| 18 | Satellite-based detec- tion of volcanic sulphur dioxide from recent eruptions in Central and South America显示文摘 | Loyola D van Geffen J Valks P Erbertseder T Van R M Thomas W Zimmer W Wiβkirehen K | 2008 | Advances in Geosciences2008，14，： | 1 |
| 19 | Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging显示文摘 | Zimmer J P Kim S W Ohnishi S | 2006 | Journal of the American Chemical Society2006，128，8： | 1 |
| 20 | First isolation of an isoprene synthase gene from poplar and successful expression of the gene in Escherichia coli显示文摘 | Miller B Oschinski C Zimmer W | 2001 | Planta2001，213，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员