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| 1 | Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine显示文摘Hepatitis B virus(HBV) infection is a global health problem. It is estimated there are more than 2 billion individuals exposed to the virus and 250 million are chronically infected. Hepatitis B is the cause of more than 600000 annual deaths due to cirrhosis and hepatocellular carcinoma. An effective vaccine exists and preventative initiatives center around universal vaccination especially in those at highest risk. Effective vaccination algorithms have led to a significant decline in the development of new infections and its devastating consequences. The vaccine is administered intramuscularly in three doses, with 95% showing long lasting serologic immunity. An additional fourth dose or a repeated higher dose three course regimen is given to those that fail to show immunity. Despite these additional regimens, some remain vulnerable to hepatitis B and are deemed nonresponders. Individuals with chronic disease states such as kidney disease, liver disease, diabetes mellitus, as well as those with a genetic predisposition, and those on immunomodulation therapy, have the highest likelihood of non-response. Various strategies have been developed to elicit an immune response in these individuals. These include increased vaccination dose, intradermal administration, alternative adjuvants, alternative routes of administration, co-administration with other vaccines, and other novel therapies. These alternative strategies can show improved response and lasting immunity. In summary, HBV vaccination is a major advance of modern medicine and all individuals at risk should be sought and vaccinated with subsequent adequate titers demonstrated. | Saqib Walayat Zohair Ahmed Daniel Martin Srinivas Puli Michael Cashman Sonu Dhillon | 2015 | World Journal of Hepatology2015，7，24： | 12 |
| 2 | Pyogenic liver abscess caused by Fusobacterium in a 21-year-old immunocompetent male显示文摘A 21-year-old male with no significant past medical history, presented with right upper quadrant(RUQ) abdominal pain along with fevers and chills. Lab work revealed leukocytosis, anemia, and slightly elevated alkaline phosphatase. Viral serology for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus were negative and he was immunocompetent.Computed tomography imaging revealed hepatic abscesses, the largest measuring 9.5 cm. Empiric antibiotics were started and percutaneous drains were placed in the abscesses. Anaerobic cultures from the abscesses grew Fusobacterium nucleatum. This is a gram negative anaerobic bacteria; a normal flora of the oral cavity. Fusobacterium is most commonly seen in Lemiere's disease, which is translocation of oral bacteria to the internal jugular vein causing a thrombophlebitis and subsequent spread of abscesses. Our patient did not have Lemiere's, and is the first case described of fusobacterium pyogenic liver abscess in a young immunocompetent male with good oral hygiene. This case was complicated by sepsis, empyema, and subsequent abscesses located outside the liver. These abscesses' have the propensity to flare abruptly and can be fatal. This case not only illustrates fusobacterium as a rare entity for pyogenic liver abscess, but also the need for urgent diagnosis and treatment. It is incumbent on physicians to diagnose and drain any suspicious hepatic lesions. While uncommon, such infections may develop without any overt source and can progress rapidly. Prompt drainage with antibiotic therapy remains the cornerstone of therapy. | Zohair Ahmed Saurabh K Bansal Sonu Dhillon | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 3 | High HbA1c is associated with higher risk of ischaemic stroke in Pakistani population without diabetes显示文摘Context:The role of glycated haemoglobin(HbA1c)in the prediction of ischaemic stroke in individuals without diabetes is underestimated.Aims:We performed a study to analyse the role of HbA1c in the risk prediction of ischaemic stroke in Pakistani population without diabetes.We further studied the difference between HbA1c values of individuals with diabetes and without diabetes with stroke.Settings and design:Single centre,case–control.Materials and methods:In phase I,a total of 233 patients without diabetes with ischaemic stroke and 245 as controls were enrolled.Association of HbA1c levels,lipid profiles and blood pressure recordings with ischaemic stroke was analysed.In phase II,comparison was done between diabetics and nondiabetics with stroke.Statistical analysis:Comparison of the mean variables was performed with Student’s t-tests.Logistic regression analysis with ischaemic stroke as the dependent variable was performed for phase I.Results:In phase I,the ischaemic stroke group had significantly higher HbA1c levels(5.9±2.9%vs 5.5±1.6%)compared with controls(p<0.05).Triglyceride cholesterol,high-density lipoprotein cholesterol,systolic blood pressure,diastolic blood pressure and HbA1c were the significant determinants of stroke(p<0.05).In phase II,mean HbA1c values were significantly higher in the diabetes group(7.6±2.1 vs 6.1±2.3)(p<0.05)but other parameters were not statistically significantly different(p>0.05).Conclusions:Higher HbA1c indicated a significantly increased risk for ischaemic stroke.An HbA1c value above 5.6%(prediabetic range)predicted future risk of stroke and efforts to maintain glucose level within the normal range(≤5.6%)in individuals with high cardiovascular risk are important. | Ali Zohair Nomani Sumaira Nabi Shahzad Ahmed Mansoor Iqbal Haris Majid Rajput Suhail Rao | 2016 | Stroke & Vascular Neurology2016，1，3： | 2 |
| 4 | Behavior of some organophosphorus and organochlorine pesticides in potatoes during soaking in different solutions 显示文摘 | Zohair A | 2001 | Food Chem Toxicol2001，39，7： | 1 |
| 5 | Latest methods of image enhancement and restoration for computed tomography: A concise review 显示文摘 | Zohair Al-Ameen Shamil AL-Ameen | 2015 | Applied Medical Informatics2015，36，1： | 1 |
| 6 | Serum high-sensitivity C- reactive protein and lipoprotein(a) levels:a comparison between diabetic and non-diabetic patients with coronary artery disease 显示文摘 | Shahid HS Kurdi MI Zohair AA | 2011 | Med J Malaysia2011，66，2： | 1 |
| 7 | Insecticidal and Ovicidal Effects of the Seed Extract of Atriplex Canescens against Culex Quinquefasciatus显示文摘 | Nazar A. Ouda Badia&CloseCurlyQuote a M. Al-Chalabi Fawzia M.R. Al-Charchafchi Zohair H. Mohsen | 1998 | Pharmaceutical Biology1998，，1： | 1 |
| 8 | Residues of polycyclic aromatic hydrocarbons(PAHs),polychlorinated biphenyls(PCBs)and organo-chlorine pesticides in organically-farmed vegetables显示文摘 | ZOHAIR A SALIM A B SOYIBO A A | 2006 | Chemosphere2006，63，： | 1 |
| 9 | A simple procedure for reducing lead content in fish显示文摘 | Salim A Hassanin M A Zohair A | 2003 | Food and Chemical Toxicology2003，41，： | 1 |
| 10 | Residues of polycyclic aromatic hydrocarbons (PAHs) , polychlo- rinated biphenyls (PCBs) and organochlorine pesticides in organically-farmed vegetables 显示文摘 | Zohair A Salim A B Soyibo A A Beck A J | 2006 | Chemosphere2006，63，4： | 1 |
| 11 | Behaviour of some organophosphorus and organochlorine pesticides in potatoes during soaking in different solutions显示文摘 | ZOHAIR A | 2001 | Food Chem Toxicol2001，39，2： | 1 |
| 12 | A Comparative Effect of Mash and Pellet Feed on Broiler Performance and Ascites at High Altitude (Field Study)显示文摘 | Zohair G A Al-Maktari G A Amer M M | 2012 | Global Veterinaria2012，9，2： | 1 |
| 13 | Behaviour of some organophosphorus and organi- chlorine pesticides in potatoes during soaking in different so- lutions显示文摘 | Zohair A | 2001 | Food and Chemical Toxicology2001，39，7： | 1 |
| 14 | Insecticidal and Ovicidal Effects of the Seed Extract of Atriplex Canescens against Culex Quinquefasciatus显示文摘 | Nazar A. Ouda Badia&CloseCurlyQuote a M. Al-Chalabi Fawzia M.R. Al-Charchafchi Zohair H. Mohsen | 1998 | Pharmaceutical Biology1998，，1： | 1 |
| 15 | Residues of polycyclic aromatic hydrocarbons(PAHs),polychlorinated biphenyls(PCBs)and organochlorine pesticides in organically-farmed vegetables显示文摘 | Zohair A Salim A B Soyibo A A | 2006 | Chemosphere2006，63，4： | 1 |
| 16 | Cognitive Attraction Theory and Moral Judgment显示文摘 | Zohair Chentouf | 2013 | Psychology2013，，01： | 1 |
| 17 | Review of acute ischaemic stroke in Pakistan:progress in management and future perspectives显示文摘Ischaemic stroke is a major cause of neurological morbidity and mortality.The objective of this review article is to summarise facts pertaining to acute ischaemic stroke and its various aspects in a developing country like Pakistan,where resources are limited and the healthcare system is underdeveloped.No large-scale epidemiological studies are available to determine the true incidence of stroke in Pakistan.We reviewed the available literature on stroke from Pakistan and through this article we primarily aim to present the current acute ischaemic stroke management in Pakistan in juxtaposition to that of the developed world.We also intend to highlight areas for future development and improvement in management.The routine practice in Pakistan is that of using stat dose of aspirin in emergency(ER)at large with only a handful of centres offering thrombolytic therapy with recombinant tissue plasminogen activator for acute ischaemic stroke.This too is faced with the problem of long window periods before the patient reaches a proper stroke care centre.The facilities of interventional therapies like arterial thrombolysis and endovascular surgery are non-existent and rehabilitation facilities limited.The opportunities for training physicians in acute stroke are also scarce.Stroke in children is underdiagnosed and that in women not availing facilities at stroke care centres.While basic research has gained pace regarding local demographic data,advanced research and genetic studies are extremely limited.The field of stroke neurology needs to grow at a substantial pace in Pakistan to be at par with the developed world. | Ali Zohair Nomani Sumaira Nabi Mazhar Badshah Shahzad Ahmed | 2017 | Stroke & Vascular Neurology2017，2，1： | 1 |
| 18 | Behaviour of some organophosphorus and organochlorine pesticides in potatoes during soaking in different solutions显示文摘 | Zohair A | 2001 | Food Chem Toxicol2001，39，7： | 1 |
| 19 | Behaviour of some organophosphorus and or- ganochlorinepesticides in potatoes during soaking in dif- ferent solutions 显示文摘 | Zohair A | 2001 | Food Chem Toxicol2001，39，7： | 1 |
| 20 | Regional Polices,Firm Characteristics and Exporting in the Indian State of Karanataka显示文摘 | Pradhan J P Zohair M and Alagawadi M V | 2013 | Foreign Trade Review2013，48，1： | 1 |
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