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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | 皮肤平滑肌瘤免疫组化2-琥珀酸半胱氨酸(2SC)和延胡索酸水化酶(FH)染色有助于HLRCC(遗传性平滑肌瘤病及肾细胞癌综合征)的诊断显示文摘遗传性平滑肌瘤病及肾细胞癌综合征(HLRCC)系因延胡索酸酶(FH)基因发生胚系突变,使患者发生皮肤平滑肌瘤、子宫肌瘤和肾细胞癌(RCC)的风险增加。HLRCC相关性。肾肿瘤具有临床侵袭性,患者可从监测和早期检测中获益。与HLRCC相关的皮肤平滑肌瘤具有肿瘤发生早且为多发性等典型特征。已知RCC和子宫肌瘤的某些形态学特征,如核周空晕包绕大的嗜酸性巨核仁及胞质内嗜酸性包涵体与FH突变有关。同时RCC和子宫肌瘤免疫组化2SC和FH表达也被很好的证明与FH相关基因突变状态有关。为了解皮肤平滑肌瘤的形态学和免疫组化特征是否有预测FH基因突变的作用,作者进行了研究。 | Benjamin B Jarish C Zoltan N 向娟 余英豪 | 2017 | 临床与实验病理学杂志2017，33，4： | 1 |
| 3 | Assessing the logistics efficiency of European countries by using the DEA-PC methodology 显示文摘 | RITAM S ZOLTAN B | 2014 | Transport2014，29，2： | 1 |
| 4 | Angiogene- sis in rheumatoid arthritis 显示文摘 | ZOLTAN S TIMEA B GYORGY P | 2009 | Autoimmunity2009，42，7： | 1 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | Possible coupling reactions of functional silanes and polypropylene显示文摘 | Demjén Zoltan Pukanszky Béla Foldes Eniko | 1999 | Polymer1999，4，7： | 1 |
| 7 | The Missing Link; Knowledge Diffusionand Entrepreneurship in Endogenous Growth 显示文摘 | BRAUNERHJELM PONTUS ACS ZOLTAN J AUDRETSCH DAVID B CARLSSON B | 2010 | Small Bus Econ2010，，34： | 1 |
| 8 | Innovation, market structure,and firm size显示文摘 | ZOLTAN J A DAVID B A | 1987 | The Review of Economics and Statistics1987，，69： | 1 |
| 9 | Network biology:understanding the cells functional organization显示文摘 | Albert-Laszlo B Zoltan N | 2004 | Nat Rev Genet2004，5，2： | 1 |
| 10 | Independent and joint effects of antibodies to human heat shook protein60 and chlamydia pneumoniae infection in the development of coronary AS显示文摘 | Katalin B Zoltan K Dezso V | 2001 | Circ2001，103，11： | 1 |
| 11 | Innovation, market structure, and firm size显示文摘 | ZOLTAN J Acs AUDRETSCH David B | 1987 | Review of economics and statistics1987，69，4： | 1 |
| 12 | Small-firm En try in US Manufacturing显示文摘 | Acs Zoltan J and Audretsch David B | 1989 | Economica1989，，6： | 1 |
| 13 | David synthesis of ferrocenoyl L- arginine derivatives hy homogeneous catalytic earbonylation 显示文摘 | B Janes B Zoltan F | 2009 | Synth Commun2009，39，5： | 1 |
| 14 | The protective effects of meniscal transplantation on cartilage显示文摘 | Zoltan LS Thomas EM Flona B | 2000 | J Bone Joint Surg(Am)2000，82，1： | 1 |
| 15 | Studies on The Mechanism of The Formation of The Penicillin Antligen III 显示文摘 | Levine Bernard B Ovary Zoltan | 1961 | J Exp Med1961，114，2： | 1 |
| 16 | Comparison of open path and extractive long-path FTIR techniques in detection of air poltutants显示文摘 | ZOLTAN B VIKTORIA K TAMAS O | 2006 | Applied Spectroscopy Reviews2006，41，1： | 1 |
| 17 | New-firm startups, technology, and macroeconomic fluctuations 显示文摘 | Audretsch D B Zoltan J A | 1994 | Small Business Economics1994，11，： | 1 |
| 18 | Application of acoustic resonators in photoacoustic trace gas analysis and metrology显示文摘 | Andras M Peter H Zoltan B | 2001 | Review of Scientific Instruments2001，72，4： | 1 |
| 19 | Calibration Algorithm for Current-output R-2R Ladders显示文摘 | Vargha B Zoltan I | 2001 | Instrumentation and Measurement2001，50，5： | 1 |
| 20 | Lycopene content and colour of ripening tomatoes as affected by environmental conditions 显示文摘 | Sara B Zoltan P Eva B | 2006 | Journal of the Science of Food and Agriculture2006，86，4： | 1 |
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