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| 1 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 2 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 3 | Reversible oriented surface immobilization of functional proteins on oxide surfaces显示文摘 | Evelyne L Thomas A K Zoltan D | 1997 | Analytical Chemistry1997，69，11： | 1 |
| 4 | A stilbene from the heartwood of Maclura pomifera 显示文摘 | Nina D Zoltan D Snezana F | 2003 | Journal of the Serbian Chemical Society2003，68，3： | 1 |
| 5 | Impact of living with bipolar patients: Making sense of caregivers' burden显示文摘The aim of the present review was to examine objective and subjective burdens in primary caregivers(usually family members) of patients with bipolar disorder(BD) and to list which symptoms of the patients are considered more burdensome by the caregivers. In order to provide a critical review about caregiver's burden in patients with bipolar disorder, we performed a detailed Pub Med, Bio Med Central, ISI Web of Science, Psyc INFO, Elsevier Science Direct and Cochrane Library search to identify all papers and book chapters in English published during the period between 1963 and November 2011. The highest levels of distress were caused by the patient's behavior and the patient's role dysfunction(work, education and social relationships). Furthermore, the caregiving role compromises other social roles occupied by the caregiver, becoming part of the heavy social cost of bipolar affective disorder. There is a need to better understand caregivers' views and personal perceptions of the stresses and demands arising from caring for someone with BD in order to develop practical appropriate interventions and to improve the training of caregivers. | Maurizio Pompili Désirée Harnic Xenia Gonda Alberto Forte Giovanni Dominici Marco Innamorati Konstantinos N Fountoulakis Gianluca Serafini Leo Sher Luigi Janiri Zoltan Rihmer Mario Amore Paolo Girardi | 2014 | World Journal of Psychiatry2014，4，1： | 1 |
| 6 | Phase onset time estimation at regional distances using the CUSUM algorithm显示文摘 | Zoltan A D Robert H S | 1999 | Physics of the Earth and Planetary Interiors1999，，113： | 1 |
| 7 | Geographical origin identification of pure Sri Lanka tea infusions with electronic nose,electronic tongue and sensory profile analysis显示文摘 | ZOLTAN K ISTVAN D LARINA L | | 0，，： | 1 |
| 8 | Geographical origin identification of pure Sri Lanka tea infusions with electronic nose,electronic tongue and sensory profile analysis显示文摘 | ZOLTAN K ISTVAN D LARINA L | | 0，，24： | 1 |
| 9 | Applications of higher-order spectral analysis to detection and identification of seismic and acoustic signals generated by machinery显示文摘 | ZOLTAN A D BAUMGAR D R | 1997 | SHE1997，，3081： | 1 |
| 10 | Textural trends in turbidites and slurry beds from the Oligocene flysch of the east Carpathians, Romania 显示文摘 | Zoltan Sylvester Lowe D | 2004 | Sedimentology2004，51，： | 1 |
| 11 | Measurement of See- beck coefficient using a light pulse 显示文摘 | WOOD C ZOLTAN D STAPFER G | 1985 | Rev Sci Instrum1985，56，5： | 1 |
| 12 | New-firm startups, technology, and macroeconomic fluctuations 显示文摘 | Audretsch D B Zoltan J A | 1994 | Small Business Economics1994，11，： | 1 |
| 13 | Hybrid model of a plane parallel hollow-cathode discharge显示文摘 | King K Zoltan D | 2000 | Journal of Physics D: Applied Physics2000，33，9： | 1 |
| 14 | Applications of higherorder spectral analysis to detection and identification of seis-mic and acoustic signals generated by machinery显示文摘 | Zoltan A D Baumgart D R | 1992 | SPIE (3081)1992，，： | 1 |
| 15 | On the global dynandcs of chatter in the orthogonal cutting model显示文摘 | Zoltan D David A W Eddie W | 2011 | International Journal of Non-linear Mechanics2011，46，： | 1 |
| 16 | Preparation of nanosize FeS particles on SiO2 and clay mineral supports:SAXS and moessbauer spectroscopic measurements 显示文摘 | Imre D Laszlo T Zoltan H | 1996 | Colloids and Surface A : Physicochemical and Engineering Aspect1996，119，： | 1 |
| 17 | Simple method for analysis of diquat in biological fluids and tissues by high-performance liquid chromatography显示文摘 | Cherukury Madhu Zoltan Gregus Curtis D Klaassen | 1995 | Journal of Chromatography B1995，，： | 1 |
| 18 | Recobinant DNA technology in the treatment of diabetes: insulin analogs 显示文摘 | ZOLTAN V JANET F WILLIAM C D | 2001 | Endocr Rev2001，22，5： | 1 |
| 19 | Applications of higher-order spec- tral analysis to detection and identification of seismic and a- coustic signals generated by machinery 显示文摘 | Zoltan A D Baumgar D R | 2005 | SPIE2005，，： | 1 |
| 20 | Applications of higher-order special analysis to detection and identification of seismic and acoustic signals generated by machinery 显示文摘 | ZOLTAN A D BAUMGAR D R | 1997 | SPIE1997，，3081： | 1 |
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