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		题名	作者	年代	出处	被引量
	1	Nerve growth factor involvement in liver cirrhosis and hepatocellular carcinoma显示文摘AIM: To define NGF (nerve growth factor) and its high- affinity receptor trkANGF presence and distribution in fibrotic liver and in HCC, and to verify if NGF might have a role in fibrosis and HCC. METHODS: Intracellular distribution of NGF and trkANGF were assessed by immunohistochemistry and immuno- electron microscopy in liver specimens from HCC, cirrhosis or both. ELISA was used to measure circulating NGF levels. RESULTS: NGF and trkANGF were highly expressed in HCC tissue, mainly localized in hepatocytes, endothelial and some Kupffer cells. In the cirrhotic part of the liver they were also markedly expressed in bile ducts epithelial and spindle-shaped cells. Surprisingly, in cirrhotic tissue from patients without HCC, both NGF and trkANGF were negative. NGF serum levels in cirrhotic and/or HCC patient were up to 25-fold higher than in controls. CONCLUSION: NGF was only detected in liver tissue with HCC present. Intracellular distribution suggests paracrine and autocrine mechanisms of action. Better definition of mechanisms may allow for therapeutic and diagnostic/prognostic use of NGF.	Guido Rasi Annalucia Serafino Lia Bellis Maria Teresa Lonardo Federica Andreola Manuela Zonfrillo Giovanni Vennarecci Pasquale Pierimarchi Paola Sinibaldi Vallebona Giuseppe Maria Ettorre Eugenio Santoro Claudio Puoti	2007	World Journal of Gastroenterology2007，13，37：	13
	2	Recognition of 'plastic bronchitis' in the emergency department 显示文摘	Zonfrillo MR Osterhoudt KC	2009	Pediatr Emerg Care2009，25，9：	1
	3	TCTP is a criticalsurvival factor that protects cancer cells from oxidative stress-in-duced cell-death显示文摘	Lucibello M Gambacurta A Zonfrillo M	2011	Exp Cell Res2011，317，17：	1
	4	The quadrivalent human papillomavirus vaccine:potential factors in effectiveness显示文摘	Zonfrillo NJ Hackley B	2008	J Midwifery Womens Health2008，53，3：	1
	5	A fuzzy approach for drawing S N curves in the finite life region 显示文摘	Zonfrillo G Rossi A	2011	Fatigue & Fracture of Engineering Materials & Structures2011，34，86：	1
	6	Thymosin α1 as a stimulatory agent of innate cell‐mediated immune response显示文摘	Annalucia Serafino Pasquale Pierimarchi Francesca Pica Federica Andreola Roberta Gaziano Noemi Moroni Manuela Zonfrillo Paola Sinibaldi‐Vallebona Enrico Garaci	2012	Annals of the New York Academy of Sciences2012，，1：	1
	7	Comparison of Procedures to Evaluate the Cyclic Stress-Strain Curve from Incremental Step Test显示文摘	Giovanni Zonfrillo Duccio Nappini	2015	Journal of Mechanics Engineering and Automation2015，5，6：	0

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