|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations显示文摘AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD.METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP.RESULTS: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, P<0.0001).SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, P= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , P<0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,P = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, P= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TLR4exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P= 0.06), in NOD2mut/wt: 26.7 years.CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4mutation carriers tended to present at earlier age. | Peter Laszlo Lakatos Laszlo Lakatos Ferenc Szalay Claudia Willheim-Polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos Papp Gyula Mozsik Hungarian IBD Study Group Peter Ferenci | 2005 | World Journal of Gastroenterology2005，11，10： | 14 |
| 3 | Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7显示文摘Backgroud:Blood flow re striction(BFR) with low-intensity re sistance training has been shown to result in hypertrophy of skeletal muscle.In this study,we tested the hypothesis that BFR during the rest periods between acute,high-intensity resistance exercise sessions(70% of 1 repetition maximum,7 sets with 10 repetitions) enhances the effects of the resistance training.Methods:A total of 7 healthy young men performed squats,and between sets BFR was carried out on one leg while the other leg served as a control.Because BFR was applied during rest periods,even severe occlusion pressure(approximately 230 mmHg),which almost completely blocked blood flow,was well-tolerated by the participants.Five muscle-specific microRNAs were measured from the biopsy samples,which were taken 2 h after the acute training.Results:Doppler data showed that the pattern of blood flow recovery changed significantly between the first and last BFR.microRNA-206 levels significantly decreased in the BFR leg compared to the control.The mRNA levels of RAC-β serine/threonine-protein kinase v22,nuclear re spiratory factor 1,vascular endothelial growth factor,lupus Ku autoantigen protein p70 genes(p <0.05),and paired box 7(p <0.01) increased in the BFR leg.The protein levels of paired box 7,nuclear respiratory factor 1,and peroxisome proliferator-activated receptor y coactivator 1α did not differ between the BFR leg and the control leg.Conclusion:BFR,during the rest periods of high-load resistance training,could lead to mRNA elevation of those proteins that regulate angiogenesis,mitochondrial biogenesis,and muscle hypertrophy and repair.However,BFR also can cause DNA damage,judging from the increase in mRNA levels of lupus Ku autoantigen protein p70. | Ferenc Torma Zoltan Gombos Marcell Fridvalszki Gergely Langmar Zsofia Tarcza Bela Merkely Hisashi Naito Noriko Ichinoseki-Sekine Masaki Takeda Zsolt Murlasits Peter Osvath Zsolt Radak | 2021 | Journal of Sport and Health Science2021，10，4： | 3 |
| 4 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 5 | Management of congen- ital penile curvature 显示文摘 | Peter N Zsolt K Gergely B | 2008 | J Urol2008，179，： | 1 |
| 6 | Cell cycle synchronization of mouse skin fibroblasts with nocodazole to obtain G2/M phase rich somatic cell population for nuclear transfer显示文摘 | Ching-Chien Chang Xiuchun Cindy Tian Zsolt Peter Nagy | 2002 | Fertility and Sterility2002，78，1： | 1 |
| 7 | Patient Exposure and Image Quality of Low-Dose Pulmonary Computed Tomography Angiography: Comparison of 100- and 80-kVp Protocols显示文摘 | Zsolt Szucs-Farkas Luzia Kurmann Tamara Strautz Michael A. Patak Peter Vock Sebastian T. Schindera | 2008 | Investigative Radiology2008，，12： | 1 |
| 8 | Emulated digital CNNUM solutions of PDEs 显示文摘 | Nagy Zoltan Voroshazi Zsolt Szolgay Peter | 2006 | International Journal of Circuit Theory and Applications2006，34，： | 1 |
| 9 | Impact of repeated bouts of eccentric exercise on myogenic gene expression显示文摘 | Andreas Costa Hicham Dalloul Hargita Hegyesi Peter Apor Zsolt Csende Levente Racz Mark Vaczi Jozsef Tihanyi | 2007 | European Journal of Applied Physiology2007，，4： | 1 |
| 10 | Novel hybrid separation process for solvent recovery based on positioning the extractive heterogeneous-azeotropic distillation显示文摘 | Szanyi Agnes Mizsey Peter Zsolt Fonyo | 2004 | Chemical Engineering and Processing2004，43，： | 1 |
| 11 | Efficiency of Arbitrarily Amplified Dominant Markers ( SCOT, ISSR, RAPD) for Diagnostic Fingerprinting in Tetraploid Potato显示文摘 | Ahmad M G Peter P Zsolt P Janos T | 2011 | American Journal of Potato Research2011，88，3： | 1 |
| 12 | Assessment of the current intensity for preventing ice accretion on overhead conductors显示文摘 | Zsolt Peter Masoud Farzaneh Laszlo I Kiss | 2007 | IEEETransonPowerDel2007，22，1： | 1 |
| 13 | Novel hybrid separation processes for solvent recovery based on positioning the extractive heterogeneous-azeotropic distillation显示文摘 | Agnes Szanyi Peter Mizsey Zsolt Fonyo | 2004 | Chemical Engineering and Processing2004，43，3： | 1 |
| 14 | Management of congenital penile curvature显示文摘 | Peter N Zsolt K Gergely B | 2008 | J Urol2008，179，： | 1 |
| 15 | Efficiency of arbitrarily amplified dominant rmrkers(SZXDT, ISSR, RAPD)for diagnostic fingerprinting in tetraploid potato显示文摘 | Ahmad M G Peter P Zsolt P | 2011 | American Journal of Potato Research2011，88，3： | 1 |
| 16 | Clinical importance and diagnosis of halitosis显示文摘 | AKOS N ZSOLT B PETER N | 2012 | Fogorv Sz2012，105，3： | 1 |
| 17 | Ganirelix acetate use in normal- and poor-prognosis patients and the impact of estradiol patterns显示文摘 | Daniel B. Shapiro Dorothy Mitchell-Leef Melinda Carter Zsolt Peter Nagy | 2005 | Fertility and Sterility2005，，3： | 1 |
| 18 | Expression of caveolin-1 in gastrointestinal and extraintestinal cancers显示文摘 | Márk Juhász Jie Chen Zsolt Tulassay Peter Malfertheiner Matthias P. A. Ebert | 2003 | Journal of Cancer Research and Clinical Oncology2003，，9： | 1 |
| 19 | Thoracoabdominal-Aortoiliac Multidetector-Row CT Angiography at 80 and 100 kVp: Assessment of Image Quality and Radiation Dose显示文摘 | Sebastian T. Schindera Patricia Graca Michael A. Patak Susanne Abderhalden Gabriel von Allmen Peter Vock Zsolt Szucs-Farkas | 2009 | Investigative Radiology2009，，10： | 1 |
| 20 | Sensorless IFOC of Induction Motor with Current Regulators in Current Reference Frame显示文摘 | PETER V | 2001 | IEEE Trans on Indus Applicat2001，37，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员