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| 1 | microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma显示文摘间充质的干细胞(MSC ) 被表明了为许多神经病学的疾病有有希望的治疗学的好处;然而,内在的机制糟糕被理解。这里,我们显示出 MSC 的那 intravitreal 注入在尖锐绿内障的一个老鼠模型的支持的网膜的中心细胞(RGC ) 幸存与 microglial 激活的重要抑制, TNF- , IL-1,和反应的氧种类的生产,以及 caspase-8 和 caspase-3 激活。在 vitro, MSC 禁止了两 caspase-8-mediated RGC apoptosis 和 microglial 激活,部分经由 stanniocalcin 的行动 1 (STC1 ) 。而且,我们发现了那 microRNA-21a-5p (miR-21 ) 和它的目标, PDCD4,为 STC1 生产和在 vitro 并且在 vivo 的 MSC 的 neuroprotective 性质是必要的。重要地, miR-21 overexpression 或 PDCD4 尖锐绿内障上的击倒的扩充调停 MSC 的 neuroprotective 效果。miR-21/PDCD4 轴由导致 MSC 分泌施加 neuroprotective 的 STC1 和另外的因素的以前未被认出的 neuroprotective 机制完成的这些数据热点。因此, modulating miR-21/PDCD4 轴可能是为尖锐绿内障和另外的神经病学的疾病的临床的处理的有希望的策略。 | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2017 | Journal of Molecular Cell Biology2017,9,4: | 5 |
| 2 | Form factors fB+ and in QCD and determination of I V I and I Vcs 1 显示文摘 | Li Zuohong Zhu Nan Fan Xiaojiao | 2012 | JHEP2012,05,160: | 1 |
| 3 | The B -- K form factor in The whole kinematically accessible range 显示文摘 | Li Zuohong Liang Fangying Wu Xiangyao | 2001 | Phys Rev D2001,64,057901: | 1 |
| 4 | Mushroom Poisoning Outbreaks—China,2023显示文摘Summary What is already known about this topic?Mushroom poisoning poses a significant food safety concern in China,with a total of 196 species identified in poisoning incidents by the end of 2022.What is added by this report?In 2023,the China CDC conducted an investigation into 505 cases of mushroom poisoning spanning 24 provincial-level administrative divisions.This investigation resulted in 1,303 patients and 16 deaths,yielding a case fatality rate of 1.23%.A total of 97 mushrooms were identified as the cause of 6 distinct clinical disease types,with 12 species newly documented as poisonous mushrooms in China.What are the implications for public health practice?Close collaboration among CDC staff,physicians,and mycologists remains crucial for the control and prevention of mushroom poisoning in the future. | Haijiao Li Yizhe Zhang Hongshun Zhang Jing Zhou Zuohong Chen Jiaqi Liang Yu Yin Qian He Shaofeng Jiang Yutao Zhang Yuan Yuan Nan Lang Bowen Cheng Jiaju Zhong Zhongfeng Li Chengye Sun | 2024 | China CDC weekly2024,6,4: | 0 |
| 5 | Recommendation on data collection and annotation of ocular appearance images in ptosis显示文摘Ptosis is a common ophthalmologic condition,and the diagnosis is primarily based on ocular appearance.Thediagnosis of such conditions can be improved using emerging technology such as artificial intelligence-basedmethods.However,unified data collection and labeling standards have not yet been established.This directlyimpacts the accuracy of ptosis diagnosis based on appearance alone.Therefore,in the present study,we aimedto establish a procedure to obtain and label images to devise a recommendation system for optimal recognitionof ptosis based on ocular appearances.This would help to standardize and facilitate data sharing and serve as aguideline for the development and improvisation of algorithms in artificial intelligence for ptosis. | Jie Meng Binying Lin Dongmei Li Shiqi Hui Xuanwei Liang Xianchai Lin Zhen Mao Xingyi Li Zuohong Li Rongxin Chen Yahan Yang Ruiyang Li Anqi Yan Haotian Lin Danping Huang Chinese Association of Artificial Intelligence,Medical Artificial IntelligenceBranch of Guangdong Medical Association | 2023 | Intelligent Medicine2023,3,4: | 0 |
| 6 | Corrigendum to‘microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma’显示文摘Journal of Molecular Cell Biology(2017),9(4),289‒301,https://doi.org/10.1093/jmcb/mjx022 In this article,there were errors in Figures 4D(western blotting analysis),3E and F,5G and H,and 5J and K(flow cytometry analysis).Iba1 band in Figure 4D was the same as Cleaved caspase-3 band in Figure 2F.This was caused by carelessly mistaking the latter(Cleaved caspase-3,#1)for Iba1 band due to the high similarity between images(raw blot images of these bands from three experiments are provided in the Supplementary material).The corrected Figure 4D with updated Iba1 band(#1)and quantitation graph is shown below. | Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo | 2023 | Journal of Molecular Cell Biology2023,15,4: | 0 |