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43篇 您的检索式：作者名="Zuscik"

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	题名	作者	年代	出处	被引量
1	Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.	Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton	2015	Bone Research2015，3，3：	8
2	Identification of a conserved switch residue responsible for selective constitutive activation of the β2-adrenergic receptor显示文摘	Zuscik MJ Porter JE Gaivin R Perez DM	1998	J Biol Chem1998，273，6：	1
3	Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles 显示文摘	Wei X Zhang X Zuscik MJ	2005	J Bone Miner Res2005，7，：	1
4	Reduced COX-2 expression in aged mice is associated with impaired fracture healing显示文摘	Naik A Xie C Zuscik M		0，，：	1
5	Characterization of voltage- sensitive calcium channels in growth plate ehondrocytes显示文摘	Zuscik MJ Gunter TE Puzas JE	1997	Bioehem Biophys Res Commun1997，234，2：	1
6	Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation 显示文摘	Li TF Darowish M Zuscik M J	2006	J Bone Miner Res2006，1，：	1
7	Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1 B-adrenergic receptor显示文摘	Zuscik M Chalothorn D Hellard D	2001	J Biol Chem2001，276，13：	1
8	Inhibition of be-ta-catenin signaling in articular chondrocytes results in ar-ticular cartilage destruction 显示文摘	ZHU M CHEN M ZUSCIK M	2008	Arthritis Rheum2008，58，7：	1
9	Reduced COX-2 expression in aged mice is associated with impaired fracture healing显示文摘	Naik AA Xie C Zuscik MJ		0，，02：	1
10	Smad3 deficient chondro- cytes have enhanced BMP signaling and accelerated differentiation 显示文摘	Li TF Darowish M Zuscik MJ	2006	Bone Miner Res2006，21，1：	1
11	Inhibition ofbeta-catenin signaling in articular chondrocytes results in articular cartilage destruction显示文摘	Zhu M Chen M Zuscik M	2008	Arthritis Rheum2008，58，7：	1
12	Inhibition of -catenin signaling in articular chondrocytes results in articular cartilage destruction 显示文摘	Zhu M Chen M Zuscik M	2008	Arthdtis Rheum2008，58，7：	1
13	Inhibition of beta - catenin signaling in articular chondrocytes resuhs in articular cattilage de- Struction显示文摘	ZHU M CHEN M ZUSCIK M	2008	Arthritis Rheum2008，58，7：	1
14	Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles 显示文摘	Wei X Zhang X Zuscik M J	2005	J Bone Miner Res2005，20，7：	1
15	Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction显示文摘	Zhu M Chen M Zuscik M	2008	Arthritis Rheum2008，58，7：	1
16	Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB显示文摘	Eliseev RA Schwarz EM Zuscik MJ		0，，01：	1
17	Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2显示文摘	Usui M Xing L Drissi H Zuscik M O'Keefe R Chen D Boyce BF		0，，：	1
18	Overexpression of the α1B-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy 显示文摘	Michael J Zuscik SS Sean A	2000	Nature Medicine2000，6，12：	1
19	Retinoic acid stimulates chon- drocyte differentiation and enhances bone morphogenetic protein effects through induction of Smadl and Smad5 显示文摘	Li X Schwarz EM Zuscik M J	2003	Endocrinolo- gy2003，144，6：	1
20	Smad 3 -defi- cient chondrocytes have enhanced BMP signaling and accelerated differentiation显示文摘	LI T F DAROWISH M ZUSCIK M J	2006	J Bone Miner Res2006，21，1：	1

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