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| 1 | Isolation, characterization and culture of Thy1-positive cells from fetal rat livers显示文摘瞄准:为了调查 Thy1 是否在胎儿的肝认出卵形的房间并且描绘,有教养的 Thy1- 从 E14 老鼠肝选择了房间。方法:Thy1 人口被荧光分析激活的房间 sorter 分析。Thy1 积极房间用磁性的祷告被孤立。肝的标记被西方的弄污,免疫细胞化学和 RT-PCR 检测。结果:Thy1 积极的房间的百分比在胎儿的老鼠肝(E13-E16 ) 的早开发期间减少了。E14 胎儿的肝包含了 7.8% Thy1 积极房间, 61% 为 alpha-fetoprotein (法新社) 和 25% 表示白朊是积极的。Thy1+ 人口表示了卵形的房间标记 c 工具包和 CXCR4,肝充实抄写的因素 HNF1alpha 和 HNF6, hepatocytic 标记白朊,法新社和 cytokeratin 18,并且胆汁的标记 cytokeratin 19。Thy1- 选择了房间形成的仅仅间充质的殖民地什么时候骨胶原上并且在包含浆液的媒介的 plated。选择房间能形成为 HNF1alpha 积极的肝的殖民地的 Thy1, HNF6,白朊,法新社, cytokeratin 18, cytokeratin 19 并且肝糖,当在浆液在 STO 喂食器层上成长时免费媒介。结论:为 Thy1 积极的卵形的房间在早肝是在场的胚胎的阶段。 | Zvibel Isabel Bronstein Miri Hubel Einav Bar-Lev Ella Halpern Zamir Oren Ran | 2006 | World Journal of Gastroenterology2006，12，24： | 7 |
| 2 | Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase显示文摘 | Shani Ben-Shlomo Isabel Zvibel Mati Shnell Amir Shlomai Elena Chepurko Zamir Halpern Nir Barzilai Ran Oren Sigal Fishman | 2010 | Journal of Hepatology2010，，6： | 3 |
| 3 | The effect of Ras inhibition on the proliferation,apoptosis and matrix metalloproteases activity in rat hepatic stellate cells显示文摘 | ZVIBEL I BAR ZOHAR D KLOOG Y | 2008 | Dig Dis Sci2008，53，4： | 1 |
| 4 | Expansion condition for early hepatic progrenitor cells from embryonic and neotatal rat livers 显示文摘 | Bill S Zvibel I Reid LM | 1999 | Dig Dis Sci1999，4，3： | 1 |
| 5 | Expansion condition for early hepatic progrenitor cells from embryonic and neotatal rat livers 显示文摘 | Bill S Zvibel I Reid LM | 1999 | Dig Dis Sci1999，4，3： | 1 |
| 6 | Soluble and matrix-associated heparan sulfate proteoglycans increase expression of erbB-2 and erbB-3 in colon cancer cell lines 显示文摘 | Zvibel I Brill S Halpem Z | 2001 | Int J Cancer2001，91，3： | 1 |
| 7 | Triiodothyronine and interleukin-6 (IL-6) induce expression of HGF in an immortalized rat hepatic stellate cell line 显示文摘 | Kariv R Enden A Zvibel I | 2003 | Liver Int2003，23，3： | 1 |
| 8 | Predictors for advanced fibrosis in morbidly obese nonalcoholic fatty liver patients显示文摘AIM To investigate predictors for fibrosis specifically in a high risk population of morbidly obese patients, including detailed evaluation of lifestyle. METHODS We conducted a cross-sectional study among morbidly obese patients attending the bariatric clinic at the TelAviv Medical Center between the years 2013-2014 with body mass index(BMI) above 40 or above 35 with co-morbidity. Patients with serum hepatitis B surface antigen or anti-hepatitis C virus antibodies, genetic liver diseases, autoimmune disease or high alcohol intake(≥ 30 g/d in men or ≥ 20 g/d in women) were excluded from the study. Liver fibrosis was estimated by transient elastography(Fibro Scan?), using the ‘‘XL'' probe. We collected data on age and gender, education, smoking status and amount, medical history, nutrition and lifestyle habits. All these data were collected using structured and validated questionnaires. Fasting blood test were available for a subsample. RESULTS Fibroscan was performed on a total of 91 patients, of which 77 had a valid examination according to the accepted criteria. Of those, 21% had significant fibrosis(F2) and 39% had advanced or severe fibrosis(F3 or F4). In multivariate analysis, male gender and BMI had a positive association with advanced fibrosis; the OR for fibrosis F ≥ 2 was 7.93(95%CI: 2.36-26.64, P = 0.001) for male gender and 1.33(1.11-1.60 kg/m2, P = 0.002) for BMI. The OR for fibrosis F ≥ 3 was 2.92(1.08-7.91, P = 0.035) for male gender and 1.17(1.03-1.33, P = 0.018) for BMI. Subjects were categorized to subgroups based on the combination of male gender and BMI of 40 and above. A significant dose response association with stiffness level was noted across these categories, with the highest stiffness among men with a higher BMI(P = 0.001). In addition, a significant positive correlation between pack-years cigarette smoking and liver stiffness was demonstrated among men(r = 0.54, P = 0.012).CONCLUSION In the morbidly obese population, a higher BMI, male gender and degree of smoking in men bears a greater risk for advanced nonalcoholic fatty liver disease. | Shira Zelber-Sagi Dafna Shoham Isabel Zvibel Subhi Abu-Abeid Oren Shibolet Sigal Fishman | 2017 | World Journal of Hepatology2017，9，2： | 1 |
| 9 | Glucagon-like peptide-1reduces hepatic lipogenesis via activation of AMP-activated protein kinase显示文摘 | Ben-Shlomo S Zvibel I Shnell M | 2011 | J Hepatol2011，54，6： | 1 |
| 10 | Thyroid hormones in-duce activation of rat hepatic stellate cells through increased expres-sion of p75 neurotrophin receptor and direct activation of Rho显示文摘 | ZVIBEL I ATIAS D PHILLIPS A | 2010 | Lab Invest2010，90，5： | 1 |
| 11 | Transcriptional profiling identifies genes induced by hepatocyte-derived extracellular matrix in metastatic human colorectal cancer cell lines显示文摘 | Zvibel I Wagner A Pasmanik-Chor M | | 0，，02： | 1 |
| 12 | Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase显示文摘 | Ben-Shlomo S Zvibel I Shnell M | 2011 | J Hepatol2011，54，6： | 1 |
| 13 | Expansion conditions for early hepatic progenitor cells from embryonal and neonatal rat livers 显示文摘 | Brill S Zvibel I Reid L M | 1999 | Dig Dis Sci1999，44，2： | 1 |
| 14 | Glucagon-like pep- tide-I reduces hepatic lipogenesis via activation of AMP acti- vated protein kinase显示文摘 | Ben-Shlomo S Zvibel I Shnell M | 2011 | J Hepatol2011，54，6： | 1 |
| 15 | Perinephric and epididymal fat affect hepatic metabolism in rats显示文摘 | Ben-Shlomo S Einstein FH Zvibel I | 2012 | Obesi?ty2012，20，1： | 1 |
| 16 | Chimeric molecule IL- 6/soluble receptor is a potent mitogen for fetal hepatocytes 显示文摘 | Zvibel I Brill S Kevital R | 2004 | Cell Physiol2004，200，： | 1 |
| 17 | Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase 显示文摘 | Ben-Shlomo S Zvibel I Shnell M | 2011 | J Hepatol2011，54，6： | 1 |
| 18 | Dipeptidyl peptidase 4-deficient rats have improved bile secretory function in high fat diet-induced steatosis显示文摘 | Ben-Shlomo S Zvibel I Rabinowich L | 2013 | Dig Dis Sci2013，58，1： | 1 |
| 19 | Transformation-related changes in the expression of endogenous cell lectins 显示文摘 | Raz A Memmsky L Zvibel I | 1987 | Int J Cancer1987，39，： | 1 |
| 20 | Chimeric molecule IL-6/soluble receptor is a potent mitogen for fetal hepatocytes显示文摘 | Zvibel I Brill S Kevital R | 2004 | J Cell Physiol2004，200，2： | 1 |
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