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| 1 | Developmental Lead Exposure Alters the Distribution of Protein Kinase C Activity in the Rat Hippocampus显示文摘Chronic low-level lead (Pb) exposure in children is known to cause a deficit in learning and memory. In vitro studies have demonstrated that Pb altered protein kinase C (PKC) activityt Especially, hippocampal PKC has been correlated with performance in several learning tasks. The effects of Pb exposure on hippocampal PKC were investigated during development at various postnatal ages: postnatal day (PN) 7, 14, 28, and 56. Two-tenth % Pb acetate was administered to pregnant and lactating dams and then administered to weanling rats in drinking water. PKC activity was measured in both membrane and cytosolic fractions from the hippocampi of the controls and Pb-exposed animals. Pb-induced increase in PKC activity in the cytosolic fraction was obsereved in the PN56 rats. In contrast, PKC activity was decreased by Pb at PN7 in the membrane fraction. Furthermore, a significant decrease in the ratio of membrane to cytosolic PKC activity which is representative of PKC distribution was observed in the PN28 and PN56 Pb-exposed rats relative to the same-age controls. This study indicates that chronic Pb exposure during development influences hippocampal PKC activity and distribution. These changes may be involved in the subclinical neurotoxicity of chronic Pb exposure in young children. | HWEI-HSIEN CHEN TANGENG MA ARTHUR S. HUME AND ING K. HO(Deportment of Pharmacology and Toxicology, University ofMississippi Medical Center, 2500 North State Street,Jackson, MS 39216, USA) | 1998 | Biomedical and Environmental Sciences1998，11，1： | 7 |
| 2 | Metal removal studied by a laboratory scale immobilized microalgal reactor显示文摘1IntroductionIndustrialwastewaters,particularlythosedischargedfrommanufacturingofprintedcircuitboard(PCB)andelectroplatingcon... | Arthur Lau, Yuk Shan Wong Research Center/Biology Department, Hong Kong University of Science and Technology, Clearwater Road, Kowloon, H.K. Zhang Tong ** CEDRC, Beijing 100028, China Nora F.Y.Tam Department of Biology and Chemistry, City University of Hong Kong, Kowloon, H.K. | 1998 | Journal of Environmental Sciences1998，10，4： | 3 |
| 3 | Gastrin as an autocrine growth factor in colorectal carcinoma:implications for therapy显示文摘Thereisnowconsiderableexperimentalsupportforthehypothesisthatprogastrinderivedpeptidesstimulateproliferationofthenormalcolon... | Graham S. Baldwin and Arthur Shulkes | 1998 | World Journal of Gastroenterology1998，4，6： | 3 |
| 4 | Selenium and Iodine Deficiencies and Selenoprotein Function显示文摘This paper reviews some recent findings on the interactions between selenium deficiency and iodine deficency. Both micronutrients can control the levels of selenoprotein mRNAs, particularly in the thyroid and brain. When selenium and iodine supplies are limiting the compensatory mechanisms work to minimise adverse effects on thyroid hormone metabolsm and thus neurological developtnent. The mechanisms for regulation of selenoproteins in selenium and iodine deficiency are however very tissue-specific. For example, unlike the brain and thyroid,brown adipose tissue is unable to retain selenoproteins in selenium and iodine deficiency and is therefore at greater risk from injurious effects of the deficiencies. | JOHN R. ARTHUR FERGUS NICOL JULIE H. MITCHELL AND GEOFFREY J. BECKETT(Division Of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK Cellular Endocrinology Unit,University Department of Clinical Biochemistry, The Royal In | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 5 | The impact of land use-land cover changes due to urbanization on surface microclimate and hydrology: a satellite perspective 显示文摘 | Carlson T N and Arthur S T | 2000 | Global and Planetary Changes2000，25，： | 2 |
| 6 | Exercise promotes a subcellular redistribution of calcium- stimulated protease activity in striated muscle 显示文摘 | Arthur GD Booker TS and Belcastro AN | 1999 | Can J Physiol Pharmacol1999，77，1： | 1 |
| 7 | The motivational effects of charismatic leadership: a self-concept based theory显示文摘 | Shamir Boas House Robert J and Arthur Michael B | 1993 | Organization Science1993，4，4： | 1 |
| 8 | Implicit contracts,labor mobility and unemployment显示文摘 | Richard J Arnott Arthur J Hosios and Joseph E Stiglitz | 1988 | American Economic Review1988，78，5： | 1 |
| 9 | Honeys from Different Floral Sources as lnhibitors of Enzymatic Browning in Fruit and Vegetable Homogcnates 显示文摘 | LEI CHEN AMAR MEHTA MAY BERENBAUM ARTHUR R ZANGERL and NICKI J ENGESETH | 2000 | J Agric Food Chem2000，，48： | 1 |
| 10 | OHM Rock Solid Images, Rock physics model for tight gas sand 显示文摘 | Fanklin Ruiz and Arthur Cheng | 2010 | The Leading Edge2010，29，： | 1 |
| 11 | A re-search agenda for the enterprise of the future 显示文摘 | Murray Arthur J and Greenes Kent A | 2006 | VINE2006，36，2： | 1 |
| 12 | Causal Reasoning in Econometric Models 显示文摘 | Lin Kuan-Pin and Farley Arthur M | 1995 | Decision Support Systems (S0167-9236)1995，15，2： | 1 |
| 13 | A silicon force sensor for robotics and medicine 显示文摘 | Arthur S H and Denice D D | 1995 | Sensors and Actuators A1995，50，2： | 1 |
| 14 | Career success in a boundaryless career world显示文摘 | Michael B Arthur Svetlana N Khapova and Celeste P M Wilderom | 2005 | Journal of Organizational Behavior2005，26，2： | 1 |
| 15 | Perspectives on environment and career:Anintroduction显示文摘 | Arthur M B and Lawrence B S | 1984 | Journal of OccupationalBehavior1984，5，1： | 1 |
| 16 | Theboundary-less career:A competency basedperspective显示文摘 | Defillippi R J and Arthur M B | 1994 | Journal of OrganizationalBehavior1994，15，4： | 1 |
| 17 | Perspectives on environment and career: An introduction显示文摘 | Arthur M B and Lawrence B S | 1984 | Journal of Occupational Behaviour1984，5，1： | 1 |
| 18 | The boundaryless career: A competency-based perspective显示文摘 | Defillippi R J and Arthur M B | 1994 | Journal of Organizational Behavior1994，15，4： | 1 |
| 19 | The Real Value of Online Communities显示文摘 | Armstrong Arthur and John Hagel Ⅲ | 1996 | Harvard Business Review1996，74，3： | 1 |
| 20 | On the Relationship Between Energy and GNP 显示文摘 | John kraft and Arthur Kraft | 1978 | Energy Development1978，，40： | 1 |
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