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| 1 | Feature Extraction of Chinese Materia Medica Fingerprint Based on Star Plot Representation of Multivariate Data显示文摘Objective To study a novel feature extraction method of Chinese materia medica(CMM) fingerprint.Methods On the basis of the radar graphical presentation theory of multivariate,the radar map was used to figure the non-map parameters of the CMM fingerprint,then to extract the map features and to propose the feature fusion.Results Better performance was achieved when using this method to test data.Conclusion This shows that the feature extraction based on radar chart presentation can mine the valuable features that facilitate the identification of Chinese medicine. | CUI Jian-xin1,2,HONG Wen-xue1,ZHOU Rong-juan3,GAO Hai-bo1 1.College of Electrical Engineering,Yanshan University,Qinhuangdao 066004,China 2.Key Laboratory of Measurement Technology and Instrumentation of Hebei Province,Qinhuangdao 066004,China 3.Maternal and Child Health Hospital of Qinhuangdao,Qinhuangdao 066004,China | 2011 | Chinese Herbal Medicines2011，3，2： | 14 |
| 2 | Construction of sperm-specific lactate dehydrogenase DNA vaccine and experimental study of its immuno-contraceptive effect on mice显示文摘Lactate dehydrogenase C4 (LDHC4) is a key enzyme for sperm metabolism. It is distributed specifically in testis and is highly immunogenic. In this study, two DNA vaccines pVAX1-hLDHC and pVAX1-mLDHC were constructed by inserting coding sequences of human and mice LDHC4 into the eukaryotic ex-pression vector pVAX1. The production of LDHC4 specific antibodies was induced in the sera of vac-cinated mice and the reproductive tract secretions of vaccinated female mice through immunization by mucosal surface instillation. Furthermore, the antibody titer increased with the times of immunization. In the mating experiment, the number of newborns of the vaccinated mice reduced significantly and some immunized female mice even lost the ability to bear any offsprings, suggesting that the difference between the immunized and control mice was statistically significant. Sperm agglutination analysis indicated that both the antisera from immunized mice and the reproductive tract secretions of vacci-nated female mice could agglutinate normal sperms. Results of immunohistochemistry showed that the antibodies present in the sera of immunized mice and the reproductive tract secretions of vaccinated female mice could specifically react with LDHC4 antigen, which mainly locates in the cytoplasm, acrosome membrane externa and acrosome capsule of the sperm. Taken together, our results indicated that the constructed contraceptive DNA vaccines did yield immunocontraceptive effects on mice and this would enable clinical trials in near future. | CHEN Yong*, ZHANG Duo*, XIN Na, XIONG YongZhong, CHEN Ping, LI Bo, TU XiangDong & LAN FengHua Research Laboratory of Medical Genetics, PLA Institute of Technology for Birth Control, Fetal Health and Child Growth, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China | 2008 | Science China(Life Sciences)2008，51，4： | 3 |
| 3 | Spatial and temporal regulation of collagenases-3, -4,and stromelysin -3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosis显示文摘Matrix metalloproteinases (MMPs) are a family of extracellular proteases capable of degrading various proteinaceous components of the extracellular matrix (ECM).They have been implicated to play important roles in a number of developmental and pathological processes, such as tumor metastasis and inflammation. Relatively few studies have been carried out to investigate the function of MMPs during postembryonic organ-development. Using Xenopus laevis development as a model system, we demonstrate here that three MMPs, stromelysin-3 (ST3),collagenases-3 (Col3), and Col4, have distinct spatial and temporal expression profiles during metamorphosis as the tadpole transforms into a frog. In situ hybridizations reveal a tight, but distinct, association of individual MMPs with tissue remodeling in the tail and intestine during metamorphosis. In particular, ST3 expression is strongly correlated with apoptosis in both organs as demonstrated by analyses of serial sections with in situ hybridization for ST3 mRNA and TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin nick end labeling) for apoptosis, respectively. On the other hand, Col3 and Col4 MMPs in Xenopus laevis development are present in regions where extensive connective tissue remodeling take place. These results indicate that ST3 is likely to play a role in ECM-remodeling that facilitateapoptotic tissue remodeling or resorption while Col3 and Col4 appear to participate in connective tissue degradation during development. | DAMJANOVSKI SASHKO ATSUKO ISHIZUYAOKA YUN-BO SHI (Laboratory of Molecular Embryology, Building 18T, Rm. 106, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA)(Department Of Histology and | 1999 | Cell Research1999，9，2： | 3 |
| 4 | Risk Factors of Learning Disabilities in Chinese Children in Wuhan显示文摘Objective To investigate prevalence rate of learning disabilities (LD) in Chinese children, and to explore related risk factors, and to provide theoretical basis for preventing such disabilities.Methods One thousand and one hundred fifty one children were randomly selected in primary schools. According to criteria set by ICD-10, 118 children diagnosed as LD were classified into the study group. Four hundred and ninety one children were classified into the normal control group. Five hundred and forty two children were classified into the excellent control group. The study instruments included PRS (The pupil rating scale revised screening for learning disabilities), Conners' children behavior check-list taken by parents and YG-WR character check-list. Results The prevalence rate of LD in Chinese children was 10.3%. Significant differences were observed between LD and normally learning children, and between the LD group and the excellent group, in terms of scores of Conners' behavior check-list (P<0.05). The study further showed that individual differences in character between the LD group and the control groups still existed even after controlling individual differences in age, IQ, and gender. Some possible causal explanations contributing to LD were improper teaching by parents, low educational level of the parents, and children's characteristics and social relationships. Conclusion These data underscore the fact that LD is a serious national public health problem in China. LD is resulted from a number of factors. Good studying and living environments should be created for LD children. | BIN YAO AND HAN-RONG WUDepartment of Children and Adolescent Health, Maternity and Child Health Care, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China | 2003 | Biomedical and Environmental Sciences2003，16，4： | 2 |
| 5 | Organizations as adaptive systems in complex environments:The cases of China显示文摘 | Boisot M and Child J | 1999 | Organization Science1999，10，： | 1 |
| 6 | Practice parameter for the use of stimiulant madications in the treatment of children,adolescents andadults显示文摘 | Americal Academy of Child and Adolescent Psychiatry official Action | 2002 | J Am Acad Child Adolesc Psychiatry2002，42，2： | 1 |
| 7 | Sexuality education for children and adolescents显示文摘 | Committee on Psychosocial Aspects of Child and Farn | 2001 | Pediatrics2001，108，： | 1 |
| 8 | Electronic fetal heart rate monitoring:research guidelines for interpreatation显示文摘 | National Institute of Child Health and Human Development Research Planning Workshop | 1997 | Am Obstet Gynecol1997，177，： | 1 |
| 9 | 'Institutional Entrepreneurship in Buiding an Environmental Protection System for the People's Republic of China'显示文摘 | John Child Yuan Lu and Terence Tsai | 2007 | 0rganization Studies2007，28，7： | 1 |
| 10 | A Qualitative Study of the Current Practices of 'No- frillsAirlines Operating in the UK显示文摘 | Gilbert Child and Bennett | 2001 | Journal of Vacation Marketing2001，，4： | 1 |
| 11 | American Academy of Pediatrics显示文摘 | Clinical practice guideline:diagnosis and evaluation of the child with attention deficit/hyperactivity disorder | 2000 | Pediatrics2000，105，5： | 1 |
| 12 | Failure to thrive as a manifestation of child neglect 显示文摘 | BLOCK RW KREBS NF the Committee On Child Abuse And Neg- lect | 2005 | Pediatrics2005，116，5： | 1 |
| 13 | WHO Collaborative Study Team on the Role of Breasffeeding on the Prevention of Infant Mortality显示文摘 | | 2000 | Lancet2000，355，9202： | 1 |
| 14 | Prac- tice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults 显示文摘 | American Academy of Child and Adolescent Psychiatry | 2002 | J Am Acad Child Adolesc Psychiatry2002，41，5： | 1 |
| 15 | Institutional Entrepreneurship in Building an Environmental Protection System for the People's Republic of China显示文摘 | John Child Yuan Lu and Terence Tsai | 2007 | Organization Studies2007，28，7： | 1 |
| 16 | Guidelines for the ethical conduct of medical research involving children 显示文摘 | Royal College of Paediatrics and Child Health: Ethics Advisory Committee | 2000 | Arch Dis Child2000，82，2： | 1 |
| 17 | Electronic fetal heart rate monitoring:research guidelines for interpretation显示文摘 | National Institute of Child Health and Human Development Research Planning Workshop | 1997 | Am J Obstet Gynecol1997，17，： | 1 |
| 18 | Retrieval of cloud over paramerters from multispectral satellite images显示文摘 | Arking A and Childs J D | 1985 | J Climate Appl Meteor1985，，： | 1 |
| 19 | The assessment and management of acute pain in infants, children, and adolescents 显示文摘 | American Academy of Pediatrics Committee on Psychosocial Aspect of Child and Family Health Task Force on pain in Infants children and Adoles - cants | 2001 | Pediatrics2001，108，3： | 1 |
| 20 | Gonorrhea in prepubertal children显示文摘 | American Academy of Pediatrics:Committee on Child Abuse and Neglect | 1998 | Pediatrics1998，101，2： | 1 |
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