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| 1 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 2 | SYNTHESIS OF OLIGO(OXYETHYLENE) MACROMONOMER CARRYING SULFONATE显示文摘This letter reports the synthesis of macromonomers, in which oligo(oxyethylene) chain and sodium salfonate are contained together. This kind of macromonomers has potential application in the fabrication of functional polymers, especially in the study of single-ionic conductors. Some preliminary characterizations of the monomer by IR, IH-NMR, etc. are given as well. | Sheng Shui ZHANG~*, Qing Guo LIU Laboratory of Solid State lonics, University of Science and Technology Beijing, Beijing 100083 Lei Ling YANG Beijing Research Institute of Chemical Industry, Beijing 100013 Gregory C FARRINGTON Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA | 1992 | Chinese Chemical Letters1992，3，10： | 4 |
| 3 | A rational cubic spline with tension显示文摘 | Gregory J A and Sarfraz M | 1990 | CAGD1990，，7： | 1 |
| 4 | Introduction to the specissue on the Web as corpus 显示文摘 | Kilgarriff Adam and Gregory Grefenstette | 2003 | Computational Linguistics2003，，29： | 1 |
| 5 | ''A Contribution to the Empirics of Economic Growth'' 显示文摘 | MANKIW GREGORY ROMER DAVID AND WELL DAVID | 1992 | Quarterly Journal of Economics1992，，： | 1 |
| 6 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 7 | Foreign Acquisitions by UK Limited Companies: Short and Long-Run Performance 显示文摘 | Gregory A and S McCorriston | 2005 | Journal of Empirical Finance2005，12，1： | 1 |
| 8 | An experimental investigation of factors affecting elastic wave velocities in porous media显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1958 | 23 (3) : 459-4931958，23，3： | 1 |
| 9 | Collateral, Loan Quality, and Bank Risk 显示文摘 | Berger Allen and Gregory Udell | 1990 | Journal of Monetary Economics1990，，25： | 1 |
| 10 | Building Models for Credit Spread 显示文摘 | Arvanitis A Gregory J and Laurent J P | 1999 | The Journal of Derivatives1999，，6： | 1 |
| 11 | Antifungal Textiles Formed Using Silver Deposition in Supercritieal Carbon Dioxide 显示文摘 | Gittard S D Daisuke H Hyde G K Scarel G Rog-er J N and Gregory N P | 2010 | Journal of Materials Engineering and Performance2010，19，： | 1 |
| 12 | Relationship Lending and Lines of Credit in Small Firm Finance 显示文摘 | Berger Allen and Gregory Udell | 1995 | Journal of Business1995，，68： | 1 |
| 13 | Treatment Outcomes 显示文摘 | Gregory B Bovasso William W Eaton and Haroutune K Armenian | 1999 | Journal of Consulting and Clinical Psychology1999，67，： | 1 |
| 14 | Hydretherma alteration and tour- maline - albite equilibrlan at the Coxheath porphyry Cu - Mo - Au deposit, Nova Scotia 显示文摘 | Gregory Lynehi and Jorge Ortega | 1997 | The Canadian Mineralogist1997，35，： | 1 |
| 15 | Principles of internal corrosion and corrosion monitoring显示文摘 | Gregory J kirmeyer and Gray S Logsdon | 1983 | Journal AWWA1983，75，2： | 1 |
| 16 | Secured Lending and Default Risk: Equilibrium Analysis, Policy Implications and Empirical Results显示文摘 | Boot Arnoud Thakor Anjan and Gregory Udell | 1991 | Economic Journal1991，，101： | 1 |
| 17 | A Contribution to the Empiric of Economic Growth 显示文摘 | Mankiw Gregory David Romer and David Weil | 1992 | Quarterly Journal of Econom- ics1992，，： | 1 |
| 18 | Conducting and Integrating Strategy Research at the International,Corporate,and BusinessLevels: Issues and Directions 显示文摘 | Dess Gregory G Anil Gupta Jean-Francois Hennart and Charles W L Hill | 1995 | Journal of Management1995，21，： | 1 |
| 19 | Balanced Realization and Model Reduction for Unstable systems 显示文摘 | KEMIN ZHOU GREGORY SALOMON AND EVA WU | 1999 | INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL (S 1049-8923)1999，9，3： | 1 |
| 20 | Griffin, Secular and Cross- Section Industrialization Patterns ; Some Further Evidence on the Kuznets- Chenery Controversy 显示文摘 | Gregory Paul and James M | 1974 | The Review of Eco- nomics and Statistics1974，，56： | 1 |
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