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| 1 | Effects of Temperature,Soil Moisture,Soil Type and Their Interactions on Soil Carbon Mineralization in Zoigê Alpine Wetland,Qinghai-Tibet Plateau显示文摘Wetland stores substantial amount of carbon and may contribute greatly to global climate change debate. However, few researches have focused on the effects of global climate change on carbon mineralization in Zoigê al-pine wetland, Qinghai-Tibet Plateau, which is one of the most important peatlands in China. Through incubation ex-periment, this paper studied the effects of temperature, soil moisture, soil type (marsh soil and peat soil) and their in-teractions on CO2 and CH4 emission rates in Zoigê alpine wetland. Results show that when the temperature rises from 5℃ to 35℃, CO2 emission rates increase by 3.3-3.7 times and 2.4-2.6 times under non-inundation treatment, and by 2.2-2.3 times and 4.1-4.3 times under inundation treatment in marsh soil and peat soil, respectively. Compared with non-inundation treatment, CO2 emission rates decrease by 6%-44%, 20%-60% in marsh soil and peat soil, respec-tively, under inundation treatment. CO2 emission rate is significantly affected by the combined effects of the tempera-ture and soil type (p < 0.001), and soil moisture and soil type (p < 0.001), and CH4 emission rate was significantly af-fected by the interaction of the temperature and soil moisture (p < 0.001). Q10 values for CO2 emission rate are higher at the range of 5℃-25℃ than 25℃-35℃, indicating that carbon mineralization is more sensitive at low temperature in Zoigê alpine wetland. | GAO Junqin OUYANG Hua LEI Guangchun XU Xingliang ZHANG Mingxiang | 2011 | Chinese Geographical Science2011，21，1： | 23 |
| 2 | Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern显示文摘Dear Editor,As of October,2021,SARS-CoV-2 has infected more than 230 million people;promoting roll-out vaccinations could help build herd immunity for the pandemic.However,the waning of antibody in magnitude and decreased protective efficacy in multiple types of vaccines have been reported. | Jingwen Ai Haocheng Zhang Qiran Zhang Yi Zhang Ke Lin Zhangfan Fu Jieyu Song Yuanhan Zhao Mingxiang Fan Hongyu Wang Chao Qiu Yang Zhou Wenhong Zhang | 2022 | Cell Research2022，32，1： | 19 |
| 3 | Effect of Root Architecture on Structural Stability and Erodibility of Topsoils during Concentrated Flow in Hilly Loess Plateau显示文摘Traditional vegetation techniques for the control of concentrated flow erosion are widely recognized, whereas only a few studies have experimentally investigated the impacts of belowground roots on the erodibility of topsoils in semi-arid areas. To quantify the effects of root architectures on soil erodibility and its relevant structural properties, simulated flow experiments were conducted at six-week intervals from 18 July to 20 October in 2012 in the hilly Loess Plateau. Five treatments were: 1) bare(control), 2) purple alfalfa(Medicago sativa), representing tap roots(T), 3) switchgrass(Panicum virgatum), representing fibrous roots(F), 4) purple alfalfa and switchgrass, representing both tap and fibrous roots(T + F), and 5) natural recovery(N). For each treatment, soil structural properties and root characteristics were measured at an interval of six weeks. Soil anti-scouribility was calculated. Results showed that grass planting slightly reduced soil bulk density, but increased soil aggregate content by 19.1%, 10.6%, 28.5%, and 41.2% in the treatments T, F, T + F, and N, respectively. Soil shear strength(cohesion and angle of internal friction(φ)) significantly increased after the grass was planted. As roots grew, soil cohesion increased by 115.2%–135.5%, while soil disintegration rate decreased by 39.0%–58.1% in the 21 th week compared with the recorded value in the 9th week. Meanwhile, root density and root surface area density increased by 64.0%–104.7% and 75.9%–157.1%, respectively. No significant differences in soil anti-scouribility were observed between the treatments of T and F or of T + F and N, but the treatments of T + F and N performed more effectively than T or F treatment alone in retarding concentrated flow. Soil aggregation and root surface-area density explained the observed soil anti-scouribility during concentrated flow well for the different treatments. This result proved that the restoration of natural vegetation might be the most appropriate strategy in soil reinforcement in the hilly Loess Plateau. | LI Qiang LIU Guobin ZHANG Zheng TUO Dengfeng XU Mingxiang | 2015 | Chinese Geographical Science2015，25，6： | 13 |
| 4 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 5 | 3-year Treatment of Tenofovir Alafenamide vs.Tenofovir Disoproxil Fumarate for Chronic HBV Infection in China显示文摘Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of China.We report 3-year results from two phase 3 studies with TAF in China(Clinicaltrials.gov:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled analysis.Results:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between groups.The overall mean age was 38 years and 73%were male.The mean HBV DNA was 6.4 log10 IU/mL.The median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral use.At week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%vs.TDF at 79%,and TAF at 93%vs.TDF at 92%for the HBeAg-positive and-negative patients,respectively.In each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were similar.Treatment was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density vs.TDF at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years. | Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty Anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 7 |
| 6 | From Basin Black Shales to Platform Carbonate Rocks:A Study on Sequence Stratigraphy for the Lower Cambrian of the Upper-Yangtze Region in South China显示文摘在 Upper-Yangtze 区域,特别在贵州省和它的邻近的区域,更低寒武纪很好被开发并且由从盆外形的黑页岩的继任是显著的焦化站台外形的岩石。从 Sinian 发生在拐弯到的站台的淹死的事件寒武纪导致了一套黑页岩,即 Niutitang 形成,它完成底部部分更低寒武纪。与沉积环境变浅,一套碳酸盐摇,即 Qingxudong 形成,在最高的部分被形成更低寒武纪。因此,更低在学习区域寒武纪使能进一步的一个秒顺序序列起来细分进五个第三顺序的序列,并且形成违反回归的定期周期的继任。为在秒顺序顺序的第三顺序的序列有一个定期垂直的叠模式。从底部到顶,继任“ CS (压缩的节)+HST (高看台的系统道) ”第三顺序的序列被变成继任“ TST (transgressive 系统道)+CS+HST' 。相应地,淹死类型顺序边界被变成暴露类型那条。因此,秒顺序和第三顺序的序列有类似的沉积外形的体系结构。有这些时间的变化的伴随物,更低与包含五个第三顺序的序列的 1000 m 的厚度寒武纪被变成不能与加深沉积环境向东南识别第三顺序的序列的压缩继任。根据第三顺序的序列的基本特征,即整齐 o 在空间和沉积环境的变化的同步性的沉积外形的继任及时,在在不同 paleogeographical 背景的主要的记载的节的第三顺序的序列的详细部门成为基础建立能在 stratigraphic 记录表明改变外形的表面的二种类型和 diachronism 的二种类型的 sequence-stratigraphic 框架。这个 sequence-stratigraphic 框架从盆外形的黑页岩形成的压缩继任的库显示出碳酸盐平台的成长进程。从 Sinian 在拐弯源于快速的违反到寒武纪生态的空间变得开,它形成了为“寒武纪的生物爆炸”设定的 paleogeographical 的先前的条件。最终,在 depositional 事件之间的基因关系和生物差异的事件是很复杂的并且在那里仍然是以后需要推进研究的大量问题。 | MEI Mingxiang MA Yongsheng ZHANG Hai MENG Xiaoqing CHEN Yonghong | 2007 | Acta Geologica Sinica(English Edition)2007，81，5： | 6 |
| 7 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 8 | Glassy metallic plastics显示文摘This paper reports a class of bulk metallic glass including Ce-, LaCe-, CaLi-, Yb-, and Sr-based metallic glasses, which are regarded as glassy metallic plastics because they combine some unique properties of both plastics and metallic alloys. These glassy metallic plastics have very low glass transition temperature (Tg^25oC to 150oC) and low Young’s modulus (~20 GPa to 35 GPa). Similar to glassy plastics, these metallic plastics show excellent plastic-like deformability on macro-, micro- and even nano-scale in their supercooled liquid range and can be processed, such as elongated, compressed, bent, and imprinted at low temperatures, in hot water for instance. Under ambient conditions, they display such metallic properties as high thermal and electric conductivities and excellent mechanical properties and other unique properties. The metallic plastics have potential applications and are also a model system for studying issues in glass physics. | LI JianFu, WANG JunQiang, LIU XiaoFeng, ZHAO Kun, ZHANG Bo, BAI HaiYang, PAN MingXiang & WANG WeiHua Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 2 |
| 9 | Mutations in DNAH8 contribute to multiple morphological abnormalities of sperm flagella and male infertility显示文摘Asthenoteratospermia is an important cause of male infertility.Here,we report two infertile patients with severe asthenoteratospermia accompanied by new genetic abnormality.Whole-exome sequencing and bioinformatics analysis suggested that compound heterozygous mutations in DNAH8(MIM:603337)may be responsible for multiple morphological abnormalities of the sperm flagella(MMAF).Immunofluorescence assay showed that DNAH8 protein expression was significantly decreased in the sperm tail of the patients,and electron microscopy exhibited an abnormal flagellum ultrastructure,while clinical pregnancy could be achieved by intracytoplasmic sperm injection.Therefore,the compound heterozygous mutations in the DNAH8 gene may be responsible for MMAF. | Mingxiang Weng Yanwei Sha Yu Zeng Ningyu Huang Wensheng Liu Xinzong Zhang Huiliang Zhou | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 2 |
| 10 | Kinetics of glass transition and crystallization in multicomponent bulk amorphous alloys显示文摘 | Yanxin Zhuang Deqian Zhao Yong Zhang Weihua Wang Mingxiang Pan | 2000 | Science in China Series A: Mathematics2000，，11： | 1 |
| 11 | Domain structure of hard magnetic NdAlFeCo bulk metallic glass显示文摘Magnetic domain structure of hard magnetic Nd60Al10Fe20Co10 bulk metallic glass (BMG) has been studied by using magnetic force microscopy. In the magnetic force images it is shown that the exchange interaction type magnetic domains with a period of about 360 nm do exist in the BMG, which is believed to be associated with the appearance of hard-magnetic properties in this system. As the scale of the magnetic domain is much larger than the size of the short-range ordered atomic clusters existing in the BMG, it is believed that the large areas of magnetic contrast are actually a collection of a group of clusters aligned in parallel by strong exchange coupling interaction. After fully crystallization, the BMG exhibits paramagnetism. No obvious magnetic contrast is observed in the magnetic force images of fully crystallized samples, except for a small quantity of ferromagnetic crystalline phase with low coercivity and an average size of 900 nm. | WEI Bingchen WANG Weihua PAN Mingxiang HAN Baoshan ZHANG Zhenrong HU Wenrui | 2001 | Chinese Science Bulletin2001，46，19： | 1 |
| 12 | Role of asymmetric environment on the dark mode excitation in metamaterial analogue of electromagnetically-induced transparency 显示文摘 | DONC Zhenggao LIu Hui Xu Mingxiang LI Tao WANG Shuming CAO Jingxiao ZHU Shining ZHANG Xiang | 2010 | Optics Express2010，18，22： | 1 |
| 13 | Interleukin-17A gene variants and risk of coronary artery disease: A large angiography-based study显示文摘 | Xiaolin Zhang Fang Pei MingXiang Zhang Chenghui Yan Mingfang Huang Tao Wang Yaling Han | 2010 | Clinica Chimica Acta2010，，3： | 1 |
| 14 | New‐onset diabetes after liver transplantation and its impact on complications and patient survival;肝移植后的新发糖尿病及其对并发症和预后的影响显示文摘 | Chaoyang Lv Yao Zhang Xianying Chen Xiaowu Huang Mengjuan Xue Qiman Sun Ting Wang Jing Liang Shunmei He Jian Gao Jian Zhou Mingxiang Yu Jia Fan Xin Gao | 2015 | Journal of Diabetes2015，，6： | 1 |
| 15 | Formation of Zr-based bulk metallic glasses from low purity of materials by yttrium addition显示文摘 | Zhang Yong Pan Mingxiang Zhao Deqian | 2000 | Materials Transactions JIM2000，41，11： | 1 |
| 16 | Thoracolaparoscopic Esophagectomy: Is the Prone Position a Safe Alternative to the Decubitus Position?显示文摘 | Mingxiang Feng Yaxing Shen Hao Wang Lijie Tan Yi Zhang Muhammad Asim Khan Qun Wang | 2012 | Journal of the American College of Surgeons2012，，： | 1 |
| 17 | Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer显示文摘 | Mingxiang Ye Jin Zhang Ji?n Zhang Qing Miao Libo Yao Jian Zhang | 2014 | Cancer Letters2014，，： | 1 |
| 18 | SD–GIS-Based TemporalSpatial Simulation of Water Quality in Sudden Water Pollution Accidents显示文摘 | Bo Zhang Yu Qin Mingxiang Huang | 2011 | Computers & Geosciences2011，37，7： | 1 |
| 19 | Enhancing maize's nitrogen-fixing potential through ZmSBT3, a gene suppressing mucilage secretion∞显示文摘Maize(Zea mays)requires substantial amounts of nitrogen,posing a challenge for its cultivation.Recent work discovered that some ancient Mexican maize landraces harbored diazotrophic bacteria in mucilage secreted by their aerial roots.To see if this trait is retained in modern maize,we conducted a field study of aerial root mucilage(ARM)in 258 inbred lines.We observed that ARM secretion is common in modern maize,but the amount significantly varies,and only a few lines have retained the nitrogen‐fixing traits found in ancient landraces.The mucilage of the high‐ARM inbred line HN5‐724 had high nitrogen‐fixing enzyme activity and abundant diazotrophic bacteria.Our genome‐wide association study identified 17 candidate genes associated with ARM across three environments.Knockouts of one candidate gene,the subtilase family gene ZmSBT3,confirmed that it negatively regulates ARM secretion.Notably,the ZmSBT3 knockout lines had increased biomass and total nitrogen accumulation under nitrogen‐free culture conditions.High ARM was associated with three ZmSBT3 haplotypes that were gradually lost during maize domestication,being retained in only a few modern inbred lines such as HN5‐724.In summary,our results identify ZmSBT3 as a potential tool for enhancing ARM,and thus nitrogen fixation,in maize. | Jingyang Gao Peijiang Feng Jingli Zhang Chaopei Dong Zhao Wang Mingxiang Chen Zhongliang Yu Bowen Zhao Xin Hou Huijuan Wang Zhaokun Wu Razia Sultana Jemim Haidong Yu Doudou Sun Pei Jing Jiafa Chen Weibin Song Xuecai Zhang Zijian Zhou Jianyu Wu | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 20 | Ground glass nodules with scattered or eccentric island-shaped consolidations may have poor outcomes显示文摘Background:To explore the effect of scattered or eccentric shaped types of ground glass opacity(GGO)on outcomes of patients with solid-dominant peripheral lung adenocarcinoma.Methods:We evaluated patients with solid-dominant peripheral lung adenocarcinoma,who underwent radical surgery at Zhongshan Hospital,Fudan University,between January 2013 and December 2015.Morphologically heterogeneous solid-dominant lung adenocarcinoma in imaging findings was based on the last preoperative computed tomography(CT)scans.Endpoints were recurrence-free survival(RFS)and overall survival(OS).Kaplan-Meier analysis and the log-rank test were used to estimate survival differences.Impact factors were assessed by univariable logistic regression analysis.Results:We retrospectively collected data from 200 patients,including 170 patients with central island-shaped CT imaging,18 patients with scattered shaped CT imaging,and 12 patients with eccentric shaped CT imaging.Eleven patients experienced recurrence or metastases.Kaplan-Meier survival curves showed significant survival differences between the central island-shaped type and scattered shaped or eccentric shaped type for OS(c-stage IA:5-year OS:100%vs.92.1%;HR=0.019,p=0.0025;p-stage IA:100%vs.95.2%;HR=0.146,p=0.1139)and RFS(c-stage IA:5-year RFS:100%vs.59.7%;HR=0.001,p<0.0001;p-stage IA:100%vs.64.5%;HR<0.001,p<0.0001).Univariable logistic regression analysis showed that scattered and eccentric shaped types were related to poor outcomes(p<0.012,odds ratio=18.8)。Conclusions:Relative spatial position of GGO and solid components may affect patient outcomes.Patients with scattered or eccentric shaped GGO may have a poor prognosis. | Ming Li Junjie Xi Huan Zhang Xing Jin Zhuoyang Fan Cheng Zhan Mingxiang Feng Lijie Tan Qun Wang | 2023 | Cancer Innovation2023，2，2： | 0 |
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