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| 1 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | Phosphate limitation of phytoplankton growth in the Changjiang Estuary显示文摘Laboratory experiments of bioassay with Pltaeodaetytum tricornutum, Chatoceros didymus, Chaetoreros calcitraus and Heterogtoea sp. sampled from the Changjiang Estuary in spring and summer, 1986, indicated that both N and P limit phytoplankton growth in the medium with N : P ranged between 8-30, and N limits phytoplankton production in the medium with N: P<8, while P is the limitary nutrient in the N : P>30. Generally, N : P in the Changjiang Estuary waters is 2 times higher than Redfield ratio. The bioassay experiments with high N : P water samples collected from Changjiang Estuary show that phytoplankton production is limited by P. Phytopiankton appears to give priority to the uptake of P at all periods of time. And the optimum N:P for phytoplankton growth is determined to be 18. | Hu Minghui, Yang Yiping, Xu Chunling and P. J. Harrison Oceanography Department of Xiamen University, Xiamen, ChinaSub-bureau of East China Sea, State Oceanic Administration, Shanghai, ChinaOceanography Department, U. B. C. , Canada | 1990 | Acta Oceanologica Sinica1990，9，3： | 4 |
| 3 | Do Domestic Firms Benefit from Direct Foreign Investment显示文摘 | | 1999 | American Economic Review1999，89，3： | 1 |
| 4 | The Effect of Gelatin on the Preparation of Silica Coated Iron Particles显示文摘 | WANG Gui hua 1,* and Andrew Harrison 2 (1. Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China 2. Department of Chemistry, The University of Edinburgh, Edinburgh, EH9 3JJ, UK) | 2000 | Chemical Research in Chinese Universities2000，16，3： | 1 |
| 5 | An evaluation of modified μ-Law compaading to reduce the PAPR of OFDM systems显示文摘 | Vallavaraj A Stewart B G and Harrison D K | 2010 | AEU-International Journal of Electronics and Communications2010，64，9： | 1 |
| 6 | A multilevel,identity-based approach to leadership development显示文摘 | Day D V and Harrison M M | 2007 | Human Resource Management Review2007，17，4： | 1 |
| 7 | The utilization of inorganic and organic phosphorus compounds as nutrients by eukatyotic microalgae: A multidisciplinary perspective: Part 2显示文摘 | Cembella A D Antia N J and Harrison P J | 1984 | Chemical Rubber Company Critical Reviews in Microbiology1984，10，： | 1 |
| 8 | Martingales and arbitrage in multiperiod securities markets 显示文摘 | Harrison J M and Kreps D M | 1979 | Journal of Economic Theory1979，20，： | 1 |
| 9 | A multilevel, identity-based ap- proach to leadership development显示文摘 | Day D V and Harrison M M | 2007 | Human Resource Ma- nagement Review2007，17，4： | 1 |
| 10 | Martingales and Stochastic Integrals in the Theory of Continuous Trading 显示文摘 | Harrison J M and Pliska S R | 1981 | Stochastic Processes Applications1981，11，： | 1 |
| 11 | , Do Domestic Firms Benefit From Direct foreign Investment? Evidence From Venezuela 显示文摘 | Aitken B and Harrison A | 1999 | American Economic Review1999，，89： | 1 |
| 12 | Cole, Long-term effects of heavy applications of biosolids on organic matter and nutrient content of a coarse-textured forest soil 显示文摘 | Rob Harrison Dongsen Xue Charles Henrry and Dale W | 1994 | Forest Ecology and Management1994，66，13： | 1 |
| 13 | Yesterday' s Heroes : Compensation and Creative Risk - Tak- ing 显示文摘 | Ing- Haw Cheng Harrison Hong and Jose Scheinkman | 2010 | National Bureau of Economic Research Working Paper2010，，7： | 1 |
| 14 | Conflict: an important dimension in management teams 显示文摘 | Amason A C Thompson K R Hochwarter W A and Harrison A M | 1995 | Organizational Dynamics1995，24，1： | 1 |
| 15 | Are There Spillovers f- rom Direct Foreign Investment? Evidence from Panel Da- ta for Morocco 显示文摘 | Haddad M and Harrison A | 1994 | Journal of Development Economics1994，42，： | 1 |
| 16 | asi- aticum are prevalent on wheat in southern Louisiana 显示文摘 | GALE LR HARRISON SA WARD TJ et ai Nivalenol-type populations of Fusarium graminearum and F | 2011 | Phytopatholo-gy2011，101，： | 1 |
| 17 | Creating Open Government Ecosystems:A Research and Development Agenda显示文摘 | Harrison T M Pardo T A and Cook M | 2012 | Future Internet2012，4，4： | 1 |
| 18 | Innovative Finn Behavior and Local Milieu: Exploring the Intersection of Agglomeration, Firm Effects, and Technological Change 显示文摘 | Harrison Bennett Maryellen Kelley and Jon Gant | 1996 | Economic Geography1996，72，3： | 1 |
| 19 | Eating disorders显示文摘 | Fairburn CG and Harrison PJ | 2003 | Lancet2003，361，9355： | 1 |
| 20 | Walking a tightpore: creating value through interorganizational relationships显示文摘 | Harrison | 2000 | Journal of Management2000，26，3： | 1 |
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