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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | All-dielectric silicon metalens for two-dimensional particle manipulation in optical tweezers显示文摘Dynamic control of compact chip-scale contactless manipulation of particles for bioscience applications remains a challenging endeavor,which is restrained by the balance between trapping efficiency and scalable apparatus.Metasurfaces offer the implementation of feasible optical tweezers on a planar platform for shaping the exerted optical force by a microscale-integrated device.Here we design and experimentally demonstrate a highly efficient silicon-based metalens for two-dimensional optical trapping in the near-infrared.Our metalens concept is based on the Pancharatnam–Berry phase,which enables the device for polarization-sensitive particle manipulation.Our optical trapping setup is capable of adjusting the position of both the metasurface lens and the particle chamber freely in three directions,which offers great freedom for optical trap adjustment and alignment.Two-dimensional(2D)particle manipulation is done with a relatively low-numerical-aperture metalens(NA(ML)=0.6).We experimentally demonstrate both 2D polarization-sensitive drag and drop manipulation of polystyrene particles suspended in water and transfer of angular orbital momentum to these particles with a single tailored beam.Our work may open new possibilities for lab-on-a-chip optical trapping for bioscience applications and microscale to nanoscale optical tweezers. | TEANCHAI CHANTAKIT CHRISTIAN SCHLICKRIEDE BASUDEB SAIN FABIAN MEYER THOMAS WEISS NATTAPORN CHATTHAM AND THOMAS ZENTGRAF | 2020 | Photonics Research2020，8，9： | 6 |
| 3 | Inducible resistance to Fas-mediated apoptosis in B cells显示文摘Apoptosis produced in B cells through Fas (APO-1, CD95) triggering is regulated by signals derived from other surface receptors: CD40 engagement produces upregulation of Fas expres. sion and marked susceptibility to Fas-induced cell death, whereas antigen receptor engagement, or IL-4R engagement, inhibits Fas killing and in so doing induces a state of Fas-resistance, even in otherwise sensitive, CD40-stimulated targets. Surfaceim. munoglobulin and IL-4R utilize at least partially distinct pathways to produce Fas-resistance that differentially depend on PKC and STAT6, respectively. Further, surface immunoglob- 'lin signaling for inducible Fas-resistance bypasses Bib, requires NF-GB, and entails new macromolecular synthesis. Terminal effectors of B cell Fas-resistance include the known anti-apoptotic gene products, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitory Molecule). faim was identified by differential display and exists in two alternatively spliced forms; maim-S is broadly expressed, but faim-L expression is tissue-specific. The FAIM sequence is highly evolu tionarily conserved, suggesting an important role for this molecule throughout phylogeny. Inducible resistance to Fas killing is hypothesized to protect foreign antigen-specific B cells during potentially hazardous interactions with FasL-bearing T cells, whereas autoreactive B cells fail to become Fas-resistant and are deleted via Fas-dependent cytotoxicity. Inadvertent or aberrant acquisition of Fas-resistance may permit autoreactive B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor immunity. | ROTHSTEIN THOMAS L Departments of Medicine and Microbiology, and the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA, USA | 2000 | Cell Research2000，10，4： | 4 |
| 4 | Studies on the Morphology of Natural Rubber/Polyacrylate Interpenetrating Polymer Networks显示文摘The interpenetrating polymer network(IPN) systems have attracted a lot of attention because of their unique two-phase structure and properties. There have been many publications concerning the IPNs in which poly (isoprene) (PIP) or polyacrylates (PAC) is formed as one of the networks.In the present study, Four serles of natural rubber(NR)/PAC IPNs were prepared and their morphologies were investigated with dynamic mechanics analysis(DMA) and transmission electron microscopy (TEM). | Llao Kalrong (Institute of Polymer Science, Zhangshan University, Guangzhou)Thomas C. Ward (Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA) | 1990 | Chemical Research in Chinese Universities1990，6，1： | 3 |
| 5 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 6 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 7 | Synthesis and Crystal Structure of Bis(S-methyl-β-N- (4-dimethylaminophenyl)methlenedithiocarbazate) Nickel (Ⅱ)显示文摘Reaction of nickel (Ⅱ) acetate with S-methyl-β-N-(4 dimethy-laminophenyl) methlenedithiocarbazate gave a mononuclear complex [Ni (C11H14N3S2)2]. Crystal of the title compound belongs to monoclinic systern,space group C2/cwith cell parameters a= 18. 785 (1), b= 17. 274 (1 ), c= 8. 344 (1 ) A, β= 108. 64(2)°, V= 2565(1 ) A3, Z=4, Mr= 563. 36, Dc= 1. 459 g/cm3; μ=10. 05 cm-1 andF(000) = 1176. The final refinement with 2179 observed reflections is converged withR= 0. 044 and R.= 0. 069. X-ray crystal structure analysis revealed that the coordina-tion geometry of Ni (Ⅱ) is a square-planar with two equivalent Ni -N and Ni - Sbonds. The Schiff-base ligand loses a proton from its tautomeric thiol form and is coor-dinated to the nickel atom via the mercapto sulphur and the β-nitiogen. | BIAN Zheng-Wei(Chemistry Department, Jiangsu Educational Institute. Nanjing, 210013)DUAN Chun-Ying THOMAS C. W. Mak(Coordination Chemistry Institute and State Key Laboratory ofCoordination Chemistry, Nanjing University, Nanjing 210093) | 1997 | Chinese Journal of Structural Chemistry1997，16，4： | 2 |
| 8 | Gap filling strategies for long term energy flux data sets显示文摘 | Eva Falge Dennis Baldocchi Richard Olson Peter Anthoni Marc Aubinet Christian Bernhofer George Burba Reinhart Ceulemans Robert Clement Han Dolman André Granier Patrick Gross Thomas Grünwald David Hollinger Niels-Otto Jensen Gabriel Katul Petri Keronen And | 2001 | Agricultural and Forest Meteorology2001，，1： | 2 |
| 9 | Sharp tunable and additional noise-free optical filter based on Brillouin losses显示文摘In this paper, we propose an additional noise-free, independent center frequency and bandwidth tunable optical filter based on stimulated Brillouin scattering(SBS) losses. By suppressing the out-of-band signal with two broadened symmetric SBS losses, tunable pass bandwidths from 500 MHz to 9.5 GHz and the independent center frequency tunability are demonstrated. Considering the limited SBS interaction in the center frequency range,a flat-top response with minimum 0.3 dB ripple is achieved. Assisted by the extra suppression from polarization pulling, a maximum selectivity of 20 dB and an ultrahigh 250 dB∕GHz roll-off are reached. A gain-based SBS filter adds noise to the filtered signal. However, for our proposed filter setup, no additional noise is detected due to the transparency in the passband. Considering the wide independent bandwidth and center frequency tunability, flat-top response, and low-noise characteristic, our proposed filter can be perfectly used as a supplement of most commercialized conventional tunable optical single bandpass filters, whose minimum bandwidth is limited by 10 GHz. | CHENG FENG STEFAN PREUSSLER AND THOMAS SCHNEIDER | 2018 | Photonics Research2018，6，2： | 2 |
| 10 | A mutual network synchronization method for wireless Ad hoc and sensor networks 显示文摘 | Carlos R H and Thomas K | 2008 | IEEE Transactions on Mobile Computing2008，7，5： | 1 |
| 11 | Cure characteristics and physic mechanical properties of calcium carbonate reinforcement rubber composites 显示文摘 | Aprem A S lose S Thomas S Barkoula N M and Kocsis J K | 2003 | Eur Polymer2003，3969，： | 1 |
| 12 | On the modelling of different types of imperfections in silo shells显示文摘 | Peter Knoedel Thomas Ummenhofer and Ulrich Schulz | 1995 | Thin-walled Structure1995，23，： | 1 |
| 13 | Growth and the Public Sector: A critical review 显示文摘 | Agell Jonas Thomas Lindh and Henry Ohlsson | 1997 | European Journal of Political Economy1997，，13： | 1 |
| 14 | 8-GHz Static Frequency Divider in AlInAs/InGaAs HBT Technology显示文摘 | Fields Charles H Stephen Thomas III Shi Binqiang Young Kim Boegeman Mary Montes Rosanna Martinez Kramer Allan R and Meena Madhav A Low-Power 72 | 2001 | IEEE JOURNAL OF SOLID-STATE CIRCUITS2001，36，： | 1 |
| 15 | Multiresidue Determination of Acidic Pesticides in Water by HPLC-DAD with Confirmation by GC-MS Using Conversion to the Methyl Ester with Trimethylsilyldiazomethane显示文摘 | | 2003 | J Chromatogra Sci2003，41，： | 1 |
| 16 | Lignin and carbohydrate alteration in particle-size separates of an oxisol under tropical pastures following native savanna 显示文摘 | GUGGENBERGER G ZECH W and THOMAS R J | 1995 | Soil Biology and Biochemistry1995，27，12： | 1 |
| 17 | Modeling Aspect-Oriented Compositions显示文摘 | Thomas Cottenier Aswin van den Berg and Tzilla Elrad | 2006 | Springer-Verlag2006，3844，： | 1 |
| 18 | Measuring Education Inequality: Gini Coefficient of Education for 140 countries显示文摘 | Thomas V Yah Wang and Xibo Fan | 2003 | Journal of Education Planning and Administration2003，17，1： | 1 |
| 19 | Modeling chloride diffusion in concrete effect of fly ash and slag 显示文摘 | Thomas M D A and Bamforth P B | 1999 | Cement and Concrete Research1999，，29： | 1 |
| 20 | The competitiveness of small and medium enterprises: aconceptualization with focus on entrepreneurial competencies 显示文摘 | Thomas W Y Man Theresa Lau and K F Chan | 2002 | Journal of Business Venturing2002，，17： | 1 |
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